Physical Interaction Of Chitosan-Alginate Entrapping Extract Of Papaya Leaf And Formation Of Submicron Particles Dosage Form

Untari, Budi; Wijaya, Dina Permata; Mardiyanto, Mardiyanto; Herlina, Herlina; Angraeni, Via; Firana, Ario

doi:10.26554/sti.2019.4.3.64-69

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sodium alginate in the pharmaceutical field has been used in the formation of hydrogel products. Sodium alginate is also known as a natural ingredient in the development of pharmaceutical particles for drug delivery systems (Untari et al, 2019) .…”

Section: Preparation Of Co-grinding Azithromycinmentioning

confidence: 99%

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

Mardiyanto,

Untari,

Mara

et al. 2023

Sci. Technol. Indones

View full text Add to dashboard Cite

Research to increase the solubility of active pharmaceutical ingredients is usually conducted by reducing the particle size. This research is one side that used the solid dispersion systems to increase solubility, especially on macrolide antibiotics for which there is still little information. The co-grinding technique on azithromycin-chitosan-alginate was chosen to produce a solid dispersion system. The parameters observed were changes in crystal structure, FTIR spectral patterns, morphological changes, and dissolution profile changes. The results of this research showed a change in the pattern of X-diffraction of azithromycin, physical interaction between azithromycin and the polymer, changes in the image of surface of solid dispersions, the solubility of solid dispersions in simulated-intestinal-fluid (SIF) solutions, and an increase in the dissolution rate of azithromycin indicating that the co-grinding technique to produce solid dispersions can increase the solubility of azithromycin.

show abstract

Section: Preparation Of Co-grinding Azithromycinmentioning

confidence: 99%

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

Mardiyanto,

Untari,

Mara

et al. 2023

Sci. Technol. Indones

View full text Add to dashboard Cite

show abstract

“…The use of modifying the structure of drug substances to increase solubility is a study that researchers in the pharmaceutical eld are currently actively undertaking. The drug ingredients are in the form of synthetic and semi-synthetic materials from antibiotics, antidiabetics, and anti-in ammatories (Fini et al, 2005;Pignatello et al, 2017) including the potent natural ingredients (Sandi et al, 2018;Untari et al, 2019;Watkins et al, 2015). More than 70% of the new medicinal ingredients have a problem with solubility.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

Mardiyanto

Untari

Mara

et al. 2022

Sci. Technol. Indones

Self Cite

View full text Add to dashboard Cite

The pandemic period has caused antibiotics highly recommended to cure infections. The use of macrolide antibiotics has greatly increased recently due to outbreaks of diseases that attack the human respiratory tract all of part of the world. One member of the macrolide group is erythromycin ethyl succinate which has low solubility in water. Therefore, this study aims to convert erythromycin ethyl succinate into lipid nanoparticles in an attempt to increase solubility. The method for the formation of nanoparticles is heating emulsification and homogenization. The results obtained in the form of formula 1 (F1) showed the percent encapsulation of 85.688±0.30641. The physical properties were that it has a size of 398.9±1.4 nm, a PDI of 0.3895±0.0015, and zeta potential of -17.45±0.15 mV respectively. The stability was determined by an accelerated test by the influence of extreme temperature and mechanics affecting the stability of the particles as an indication of decreasing the pH and particle precipitation. The solubility of erythromycin ethyl succinate in the form of lipid nanoparticles was increased in a comparison with the pure substance of erythromycin ethyl succinate.

show abstract

“…Nanoparticles term have a particle size range 200-500 nm that have been widely used in the pharmaceutical field and have advantages in drug delivery, namely they can overcome the solubility of poorly soluble active substances, improve poor bioavailability, modify drug delivery systems so that drugs can go directly to specific targets, and increase the stability of the active substance from the environment [2]. Nanoparticle technology can be used to help penetrate the drug into the skin because the particle size is in nanometer makes to easier for the drug to penetrate the skin layers and can help increasing the protective effect of the drug so that it is not easily degraded [3]. Nanoparticles can be applied to deliver the active substance by encapsulated.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Antioxidant Activity of Nanoparticles Loaded Jacfruit Leaf Extract (Artocarpus heterophyllus Lamk.)

Wijaya¹,

Mardiyanto²,

Herlina³

et al. 2021

Advances in Health Sciences Research

View full text Add to dashboard Cite

Jackfruit leaves extract (Artocarpus heterophyllus Lamk.) which contained flavonoid as an antioxidant was unstable and sensitive to environmental conditions. Preparation of nanoparticles loaded jackfruit leaf extract aimed to increase the antioxidant activity through optimal delivery system and maintain the stability of flavonoid from jackfruit leaf extract. Nanoparticle preparation used an ionic gelation method with chitosan, sodium alginate, and variation of calcium chloride. Characterization of nanoparticles were particle size, polydispersity index, efficiency of encapsulation, zeta potential, and XRD analysis. Based on the result, the highest percent of encapsulation efficiency in the nanoparticles with the amount of calcium chloride 40 µl was 90,76%. The characterization of nanoparticles, particle size was 244,2 nm, polydispersity index was 0,22, and zeta potential was +26,4 mV. The XRD pattern of nanoparticles loaded jackfruit leaf extract showed jackfruit leaf extract encapsulated into nanoparticles. Antioxidant activity of jackfruit leaf extract increased after encapsulation as indicated by the IC50 for nanoparticles of jackfruit leaf extract was 10,13µg/ml which indicates high antioxidant.

show abstract

Physical Interaction Of Chitosan-Alginate Entrapping Extract Of Papaya Leaf And Formation Of Submicron Particles Dosage Form

Cited by 3 publications

References 12 publications

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

Characterization and Antioxidant Activity of Nanoparticles Loaded Jacfruit Leaf Extract (Artocarpus heterophyllus Lamk.)

Contact Info

Product

Resources

About