This work extends the applications of Anderson-type Hamiltonians to include transport characterized by anomalous diffusion. Herein, we investigate the transport properties of a onedimensional disordered system that employs the discrete fractional Laplacian, (−∆) s , s ∈ (0, 2), in combination with results from spectral and measure theory. It is a classical mathematical result that the standard Anderson model exhibits localization of energy states for all nonzero disorder in one-dimensional systems. Numerical simulations utilizing our proposed model demonstrate that this localization effect is enhanced for sub-diffusive realizations of the operator, s ∈ (1, 2), and that the super-diffusive realizations of the operator, s ∈ (0, 1), can exhibit energy states with less localized features. These results suggest that the proposed method can be used to examine anomalous diffusion in physical systems where strong interactions, structural defects, and correlated effects are present.