The conceptual configuration and special features of a new high-precision real-time signal processing system for a Cooled Infrared Focal Plan Array with 320×240 detectors is presented in this note. The most critical case in the image detectors based on array elements is the Non-Uniformity Correction (NUC) between the sensitive elements due to the different characteristics of the materials in fabrication phase, especially for the IRFPAs with high elements which their non-uniformities are inherently more severe. It is the case that a mechanism for NUC between the sensitive elements needs a structure for compensation of gradual drift in the detectors' output by update the correction factors in a regular way. A feasible method, Least-Mean-Square under a compact hardware is introduced. The correction formula deduced from this approach is the best approximation polynomial of the analytic formula through theoretical analysis. Inherently, the intended detector has not a suitable timing for sending out for standard display equipments, so it is essential to have hardware for frame-to-frame grab which can help for processing applications too. Applying a capability of the sophisticated FPGAs, the contrast enhancement based on Bi-Histogram Equalization which preserves the brightness of infrared image precisely is described.