1996
DOI: 10.1006/geno.1996.0398
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Physical Mapping of a Commonly Deleted Region, the Site of a Candidate Tumor Suppressor Gene, at 12q22 in Human Male Germ Cell Tumors

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Cited by 34 publications
(34 citation statements)
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“…Previous studies demonstrated that loss of heterozygosity (LOH) at these loci occur frequently in testicular germ cell tumors, particularly in teratomas. 8,[13][14][15][16][17][18][19][20][21] Polymerase chain reaction amplification and gel electrophoresis were performed as previously described. [22][23][24][25][26] The criterion for allelic loss was complete or nearly complete absence of one allele in tumor DNA.…”
Section: Amplification Of Dnamentioning
confidence: 99%
“…Previous studies demonstrated that loss of heterozygosity (LOH) at these loci occur frequently in testicular germ cell tumors, particularly in teratomas. 8,[13][14][15][16][17][18][19][20][21] Polymerase chain reaction amplification and gel electrophoresis were performed as previously described. [22][23][24][25][26] The criterion for allelic loss was complete or nearly complete absence of one allele in tumor DNA.…”
Section: Amplification Of Dnamentioning
confidence: 99%
“…It is likely that TGCTs arise through a process of multi-step carcinogenesis and that LOH at specific loci is an important early event. Evidence for a minimal region of deletion at 12q22 (Murty et al, 1996a) as well as at 5p15, 5q11 and 5q34-q35 (Murty et al, 1996b) has been reported, though regions of consistent loss have not yet been defined. It is therefore difficult to determine which, if any, of the genes contained within these regions demonstrating LOH are fundamental to the development of invasive testicular cancer.…”
Section: Sw Faulknermentioning
confidence: 99%
“…Consequently, the loss of APAF-1 gene function leads to defects in the execution of apoptotic programmed cell death and may account for cellular resistance to chemo-, radio-, and immunotherapy. APAF-1 is located at chromosome loci 12q23 , and frequent AI in the 12q22-23 region has been reported in melanomas (Soengas et al, 2001;Fujimoto et al, 2004), male germ cell tumors (Murty et al, 1996), and pancreatic (Kimura et al, 1998;Yatsuoka et al, 2000), ovarian (Hatta et al, 1997) and gastric carcinomas (Schneider et al, 2003). In melanomas, AI is associated with a reduction of APAF-1 mRNA expression levels (Soengas et al, 2001;Fujimoto et al, 2004), and AI in the 12q22-23 region is related to poor prognosis of patients with American Joint Committee on Cancer (AJCC) stage III/IV melanoma .…”
Section: Introductionmentioning
confidence: 99%