“…This is in accordance with the principle of employing surgery before the appearance of strepto¬ mycin-resistant organisms. The complications encountered to date have been as follows: (1) two episodes of vestibular irritation, one of which responded to a reduction in dose and the other to cessation of therapy, with no further complications on resumption of treatment; (2) improve, frequently to the point where the patients can¬ not get enough to eat; abdominal distention and distress subside, though doughiness will persist; fatigue and weakness diminish as the patient progressively becomes stronger; leukorrhea diminishes; menstrual functions may return in amenorrheic patients; menstrual dysfunc¬ tion, such as metromenorrhagia, tends to improve; night sweats will most frequently subside; and the occasional patient with diarrhea will show improvement.…”