Abstract:Physical methods make it possible to combine analytical imaging with isotopic labelling in biological studies. With radioactive isotopes, trackradioautography may be used (in parallel with conventional grain-density radioautography) for high lateral resolution, even with energetic β-rays; in macroradioautography, filmless methods (gaseous detectors, scintillation counters, and storage phosphor screen devices) have remarkable performances. Neutron capture radiography is used mainly for the detection and imaging… Show more
“…Such radiation beams produce a complex dose distribution in tissue, resulting from incident fast neutrons, incident gamma-rays, and other components produced by the capture of thermal neutrons in the irradiated volume. The major dose component comes from the 10 B(n, ␣) 7 Li reaction and can actually not be described by the conventional concept of absorbed dose because the energy released in matter by the ␣-and 7 Li-particles is inhomogeneous. The range of these particles is small, therefore the clinical efficacy of the therapy is only guaranteed if the boron is located inside a tumor cell and optimal close to a sensitive area of the tumor cell, i.e., the cell nucleus.…”
Section: Bnct and The Need For Boron Analysis And Boron Imagingmentioning
confidence: 99%
“…The principle of PGRA is based on gamma-ray spectroscopy following neutron capture in 10 B. The recoiling 7 Li-nuclei from the 10 B(n, ␣) 7 Li reaction decay to the ground state of 7 Li by the emission of 478 keV photons (Fig. 1a).…”
Section: Prompt Gamma-ray Spectroscopymentioning
confidence: 99%
“…The very small dots, approximately 1 m in diameter, show the etched tracks superimposed on the stained 1-2 m tissue section. The location of each track corresponds to the near-perpendicular trajectory of an alpha-or 7 Li-particle following the absorption of a thermal neutron by 10 B during the neutron irradiation phase of the process. Next, the operator delineates various anatomical tissue regions on the HRQAR images and a computer program searches the images and bins the tracks into the corresponding delineated anatomical regions.…”
Section: High Resolution Alpha Autoradiographymentioning
confidence: 99%
“…BNCT is a biologically targeted form of radiotherapy, which exploits the ability of the non-radioactive isotope 10 B to capture thermal neutrons with a very high probability (cross-section: 3837 barn), leading to the nuclear reaction 10 B(n, ␣, ␥) 7 Li. This reaction produces 478 keV gamma-rays, He-4-particles and Li-7 recoil ions, the latter two having high linear energy transfer (LET) properties and a high relative biological effectiveness (RBE) relative to photon irradiation.…”
Section: Bnct and The Need For Boron Analysis And Boron Imagingmentioning
confidence: 99%
“…To fully understand the impact and advantages of BNCT over other treatment methods, there is a need to study the concentration, the subcellular distribution, the molecular sites of fixation, the transport and the exchange dynamics of boron in a variety of biological samples. In contrast to prior reviews that focused on physical techniques applicable to the imaging of chemical elements and their isotopes in biological samples [7] and the special aspects on boron [8,9], this review is directed towards methods adapted for BNCT including the quantitative distribution of boron and boron compounds on a microscopic and macroscopic level. Techniques and results are summarized that were developed in the context of the research project "Therapeutic Strategies for Boron Neutron Capture Therapy (BNCT): Boron Imaging", which was funded over a period of 5 years by the European Commission (Contract No.…”
“…Such radiation beams produce a complex dose distribution in tissue, resulting from incident fast neutrons, incident gamma-rays, and other components produced by the capture of thermal neutrons in the irradiated volume. The major dose component comes from the 10 B(n, ␣) 7 Li reaction and can actually not be described by the conventional concept of absorbed dose because the energy released in matter by the ␣-and 7 Li-particles is inhomogeneous. The range of these particles is small, therefore the clinical efficacy of the therapy is only guaranteed if the boron is located inside a tumor cell and optimal close to a sensitive area of the tumor cell, i.e., the cell nucleus.…”
Section: Bnct and The Need For Boron Analysis And Boron Imagingmentioning
confidence: 99%
“…The principle of PGRA is based on gamma-ray spectroscopy following neutron capture in 10 B. The recoiling 7 Li-nuclei from the 10 B(n, ␣) 7 Li reaction decay to the ground state of 7 Li by the emission of 478 keV photons (Fig. 1a).…”
Section: Prompt Gamma-ray Spectroscopymentioning
confidence: 99%
“…The very small dots, approximately 1 m in diameter, show the etched tracks superimposed on the stained 1-2 m tissue section. The location of each track corresponds to the near-perpendicular trajectory of an alpha-or 7 Li-particle following the absorption of a thermal neutron by 10 B during the neutron irradiation phase of the process. Next, the operator delineates various anatomical tissue regions on the HRQAR images and a computer program searches the images and bins the tracks into the corresponding delineated anatomical regions.…”
Section: High Resolution Alpha Autoradiographymentioning
confidence: 99%
“…BNCT is a biologically targeted form of radiotherapy, which exploits the ability of the non-radioactive isotope 10 B to capture thermal neutrons with a very high probability (cross-section: 3837 barn), leading to the nuclear reaction 10 B(n, ␣, ␥) 7 Li. This reaction produces 478 keV gamma-rays, He-4-particles and Li-7 recoil ions, the latter two having high linear energy transfer (LET) properties and a high relative biological effectiveness (RBE) relative to photon irradiation.…”
Section: Bnct and The Need For Boron Analysis And Boron Imagingmentioning
confidence: 99%
“…To fully understand the impact and advantages of BNCT over other treatment methods, there is a need to study the concentration, the subcellular distribution, the molecular sites of fixation, the transport and the exchange dynamics of boron in a variety of biological samples. In contrast to prior reviews that focused on physical techniques applicable to the imaging of chemical elements and their isotopes in biological samples [7] and the special aspects on boron [8,9], this review is directed towards methods adapted for BNCT including the quantitative distribution of boron and boron compounds on a microscopic and macroscopic level. Techniques and results are summarized that were developed in the context of the research project "Therapeutic Strategies for Boron Neutron Capture Therapy (BNCT): Boron Imaging", which was funded over a period of 5 years by the European Commission (Contract No.…”
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