2001
DOI: 10.1081/tma-100001469
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Physical Methods for in Vitro Analytical Imaging in the Microscopic Range in Biology, Using Radioactive or Stable Isotopes (Review Article)

Abstract: Physical methods make it possible to combine analytical imaging with isotopic labelling in biological studies. With radioactive isotopes, trackradioautography may be used (in parallel with conventional grain-density radioautography) for high lateral resolution, even with energetic β-rays; in macroradioautography, filmless methods (gaseous detectors, scintillation counters, and storage phosphor screen devices) have remarkable performances. Neutron capture radiography is used mainly for the detection and imaging… Show more

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Cited by 21 publications
(22 citation statements)
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“…Such radiation beams produce a complex dose distribution in tissue, resulting from incident fast neutrons, incident gamma-rays, and other components produced by the capture of thermal neutrons in the irradiated volume. The major dose component comes from the 10 B(n, ␣) 7 Li reaction and can actually not be described by the conventional concept of absorbed dose because the energy released in matter by the ␣-and 7 Li-particles is inhomogeneous. The range of these particles is small, therefore the clinical efficacy of the therapy is only guaranteed if the boron is located inside a tumor cell and optimal close to a sensitive area of the tumor cell, i.e., the cell nucleus.…”
Section: Bnct and The Need For Boron Analysis And Boron Imagingmentioning
confidence: 99%
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“…Such radiation beams produce a complex dose distribution in tissue, resulting from incident fast neutrons, incident gamma-rays, and other components produced by the capture of thermal neutrons in the irradiated volume. The major dose component comes from the 10 B(n, ␣) 7 Li reaction and can actually not be described by the conventional concept of absorbed dose because the energy released in matter by the ␣-and 7 Li-particles is inhomogeneous. The range of these particles is small, therefore the clinical efficacy of the therapy is only guaranteed if the boron is located inside a tumor cell and optimal close to a sensitive area of the tumor cell, i.e., the cell nucleus.…”
Section: Bnct and The Need For Boron Analysis And Boron Imagingmentioning
confidence: 99%
“…The principle of PGRA is based on gamma-ray spectroscopy following neutron capture in 10 B. The recoiling 7 Li-nuclei from the 10 B(n, ␣) 7 Li reaction decay to the ground state of 7 Li by the emission of 478 keV photons (Fig. 1a).…”
Section: Prompt Gamma-ray Spectroscopymentioning
confidence: 99%
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