Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties

Zhang, Ning; Chen, Hạixia; Ma, Lishuai; Zhang, Yu

doi:10.1016/j.ijbiomac.2012.12.030

Cited by 68 publications

(36 citation statements)

References 32 publications

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“…Molecular modification could change polysaccharides’ dimensional structure, molecular weight, and the substituent groups’ types, number, and positions, with impacts on bioactivities. So far, there have been dozens of molecular modification methods, including carboxymethylation (Chen and others ), sulfation (Wang and others ), selenylation (Qiu and others ), phosphorylation (Yeand others ), ultrasonic disruption (Zhang and others ), and the degradation of polysaccharides, which are generally classified as chemical, physical, and biological modifications (Figure ).…”

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

“…The concentration of acid/alkaliand reaction temperature and time is the keys to obtain degradated products with different molecular weights. Hydrochloric acid and sodium hydroxide, which can reduce the molecular weight of polysaccharides, have been used to degrade IOPS (polysaccharides from Inonotus obliquus ) (Zhangand others ). But with this treatment, their bioactivities could also be diminished, due to reduced content of uronic acid and protein, with the use of hydrochloric acid and sodium hydroxide.…”

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

“…Zhangand others () modified the polysaccharides in I. obliquus through ultrasonic modification and comparison of their antioxidant properties. This experiment used a fixed ultrasonic frequency and power, and obtained polysaccharides with lower molecular weight and better bioactivities compared with the polysaccharides gained by other physical modifications.…”

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

“…In addition, Zhu and others () used ultrasonic treatment to modify the mycelial polysaccharides from Cordyceps gunnii , and found that the ultrasonic treatment could reduce the molecular weight of polysaccharides. Similarly, Zhangand others () used thermal and ultrasonic treatment to modify the polysaccharides from I. obliquus . The results indicated that molecular weights of modified products were significantly decreased compared with unmodified polysaccharides.…”

Section: The Effect Of Molecular Modification On Physical and Chemicamentioning

confidence: 99%

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Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

415

172

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Polysaccharides are ideal natural resources for supplements and pharmaceuticals that have received more and more attention over the years. Natural polysaccharides have been shown to have fewer side effects, but because of their inherently physicochemical properties, their bioactivities were difficult to compare with those of synthetic drugs. Thus, researchers have modified the structures and properties of natural polysaccharides based on structure-activity relationships and have obtained better functionally improved polysaccharides. This review focuses on the major modification methods of polysaccharides, and discusses the effect of molecular modification on their physicochemical properties and bioactivities. Molecular modification methods mainly include chemical, physical, and biological changes. Chemical modification is the most widely used method; it can significantly increase the water solubility and bioactivities of polysaccharides by grafting onto other groups. Physical and biological modifications only change the molecular weight of a polysaccharide, and thereby change its physicochemical properties and bioactivities. Most of the molecular modifications bring about an increase in the antioxidant activity of polysaccharides, and among these, sulfated and acetylated modifications are very common. Furthermore, phosphorylation modification is the most common application to increase antitumor activity, and modified polysaccharides have been shown to have anti-HIV activity as the result of sulfated modification.

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Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

Section: The Effect Of Molecular Modification On Physical and Chemicamentioning

confidence: 99%

See 2 more Smart Citations

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

415

172

View full text Add to dashboard Cite

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“…Antioxidant activities after physical modifications and chemical modification have also been tested, such as modification by acid or alkali hydrolysis and thermal and ultrasonic treatment. The result showed better antioxidant effect after these treatments Zhang et al 2013). …”

Section: Antioxidant Activitiesmentioning

confidence: 91%

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Chen¹,

Li²

2015

Polysaccharides

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Effects of Chemical Modification on the Structure and Biological Activities of Polysaccharides Extracted from Inonotus Obliquus by Microwave

Xie,

Li,

Zhang

et al. 2024

Chemistry & Biodiversity

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A novel polysaccharide, Inonotus obliquus polysaccharide (IOP), was extracted using a microwave extraction method and subsequently subjected to modifications through sulfation, carboxymethylation, phosphorylation, and acetylation. Its physical and chemical properties were analyzed using various chemical techniques, including high‐pressure liquid chromatography, ultraviolet light, Fourier‐transform infrared spectroscopy, X‐ray diffraction, Congo red test, and scanning electron microscopy. The antioxidant capacity was assessed using DPPH, ABTS, and hydroxyl radical assays, as well as by measuring the reducing power. Additionally, hypoglycemic activity was evaluated through α‐glucosidase and α‐amylase assays. The results indicated that the chemical modifications effectively altered the physical and chemical properties, as well as the biological activities of IOP. Compared to the unmodified IOP, the derivatives exhibited reduced sugar content, uronic acid content, and molecular weight, while demonstrating varying levels of antioxidant and hypoglycemic capabilities. Notably, the carboxymethylated IOP (IOP‐C) displayed lower molecular weight, higher ABTS free radical scavenging rate, greater reducing ability, and increased α‐amylase inhibition rate. Therefore, IOP‐C shows promise as a potential edible antioxidant and hypoglycemic agent.

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Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties

Cited by 68 publications

References 32 publications

Molecular Modification of Polysaccharides and Resulting Bioactivities

Molecular Modification of Polysaccharides and Resulting Bioactivities

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Effects of Chemical Modification on the Structure and Biological Activities of Polysaccharides Extracted from Inonotus Obliquus by Microwave

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