Physical Principles and Technical Aspects of CEUS

Peniaeva, Ella I.; Sencha, Alexander N.; Kamalov, Yuly R.; Patrunov, Yury N.; Fisenko, Elena P.; Ветшева, Н. Н.; Barmin, Roman A.; Rudakovskaya, Polina G.

doi:10.1007/978-3-030-91764-7_2

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“…Hence, the scattered US echoes contain subharmonics and harmonics . Most contrast-enhanced US imaging setups preferentially detect the emission of nonlinear signals, as MB generate much larger subharmonic and harmonic responses than tissues do . If acoustic pressures exceed a certain threshold, MB undergo inertial cavitation, resulting in MB collapse and fragmentation, which is relevant for drug delivery purposes.…”

Section: Introductionmentioning

confidence: 99%

“…12 Most contrast-enhanced US imaging setups preferentially detect the emission of nonlinear signals, as MB generate much larger subharmonic and harmonic responses than tissues do. 13 If acoustic pressures exceed a certain threshold, MB undergo inertial cavitation, resulting in MB collapse and fragmentation, which is relevant for drug delivery purposes. While the mechanical index was a parameter initially designed to predict US-induced bioeffects (not related to US contrast agents), 14 it was later repurposed to estimate MB destruction.…”

Section: ■ Introductionmentioning

confidence: 99%

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Enhanced Stable Cavitation and Nonlinear Acoustic Properties of Poly(butyl cyanoacrylate) Polymeric Microbubbles after Bioconjugation

Barmin

Dasgupta

Rix

et al. 2022

ACS Biomater. Sci. Eng.

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Microbubbles (MB) are used as ultrasound (US) contrast agents in clinical settings because of their ability to oscillate upon exposure to acoustic pulses and generate nonlinear responses with a stable cavitation profile. Polymeric MB have recently attracted increasing attention as molecular imaging probes and drug delivery agents based on their tailorable acoustic responses, high drug loading capacity, and surface functionalization capabilities. While many of these applications require MB to be functionalized with biological ligands, the impact of bioconjugation on polymeric MB cavitation and acoustic properties remains poorly understood. Hence, we here evaluated the effects of MB shell hydrolysis and subsequent streptavidin conjugation on the acoustic behavior of poly(butyl cyanoacrylate) (PBCA) MB. We show that upon biofunctionalization, MB display higher acoustic stability, stronger stable cavitation, and enhanced second harmonic generation. Furthermore, functionalized MB preserve the binding capabilities of streptavidin conjugated on their surface. These findings provide insights into the effects of bioconjugation chemistry on polymeric MB acoustic properties, and they contribute to improving the performance of polymer-based US imaging and theranostic agents.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%