Physical properties and enzymatic hydrolysis of poly(l-lactide)–CaCO3 composites

Fukuda, Norio; Tsuji, Hideto; Ohnishi, Yasushi

doi:10.1016/s0141-3910(02)00125-8

Cited by 34 publications

(21 citation statements)

References 32 publications

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“…After degradation up to 240 h, many pores are generated on the surface of the bulk samples and the pores are spherical in shape with circular interconnections (Figure 11d,f). This kind of connected spherical-pore structures are due to the breakdown of swollen (amorphous) regions by the enzymatic degradation, as reported previously [16,17,18]. …”

Section: Resultssupporting

confidence: 77%

Preparation and Enzymatic Degradation of Porous Crosslinked Polylactides of Biomass Origin

Kido

Sakai

John

et al. 2014

IJMS

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To understand the enzymatic degradation behavior of crosslinked polylactide (PLA), the preparation and enzymatic degradation of both thermoplastic (linear) and crosslinked PLAs that have pore structures with different dimensions were carried out. The porous structures of the linear PLA samples were of micro and nanoporous nature, and prepared by batch foaming with supercritical CO2 and compared with the porous structures of crosslinked PLA (Lait-X) created by the salt leaching method. The surface and cross-sectional morphologies of the porous structures were investigated by using scanning electron microscopy. The morphological analysis of porous Lait-X showed a rapid loss of physical features within 120 h of exposure to proteinase-K enzymatic degradation at 37 °C. Due to the higher affinity for water, enhanced enzymatic activity as compared to the linear PLA porous structures in the micro and nanoporous range was observed.

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Section: Resultssupporting

confidence: 77%

Preparation and Enzymatic Degradation of Porous Crosslinked Polylactides of Biomass Origin

Kido

Sakai

John

et al. 2014

IJMS

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“…This kind of connected spherical-pore structure has been widely reported in the previous papers (Li et al, 2001;Cai et al, 2003). These holes are resulted from the degradation of the swollen (amorphous) region by the enzymatic attacks (Fukuda et al, 2002).…”

Section: Enzymatic Degradation Of Nano-composite Foamsupporting

confidence: 55%

Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nanocomposite Foam via Enzymatic Degradation

Bitou

Okamoto

2007

International Polymer Processing

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In order to prepare a porous three-dimensional (3-D) structure in biodegradable polyester materials we have conducted the enzymatic degradation of a poly(L-lactide) (PLLA)-based nano-composite foam, having a nanocellular structure, using proteinase-K as a degrading agent at 37°C. The surface and cross sectional morphologies of the foam recovered after enzymatic hydrolysis for different intervals were investigated by using a scanning electron microscope. The nanocellular material took up a large amount of water, which led to the swelling of the foam due to the large surface area inside the nanocelluar structure, and facilitated the enzymatic degradation of the PLLA matrix as compared with the bulk (pre-foamed) sample. Consequently, we have successfully prepared a porous 3-D structure as a remaining scaffold in the core part of the nanocomposite foam, reflecting the spherulites of the crystallized PLLA.

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“…To achieve an effective design for proposed devices, it is important to suppress the initial PGA decomposition. For examples, a crystallinity control of degradable materials by heat treatments or incorporation of basic materials is an effective method for improving the degradation characteristics [24][25][26][27][28] . Recently, an additive manufacturing has been received considerable attentions in several elds, because it has a lot of exibility in the structural design.…”

Section: Mechanical Properties Of Compositesmentioning

confidence: 99%

“…A decomposition rate of degradable plastics such as PLA and PGA can be supressed by using high-molecular-weight ones and incorporation of basic materials 10,[24][25][26][27][28]31) . If calcium phosphates or calcium carbonates are employed as the basic materials, the bone ingrowth could be promoted by the calcium release.…”

Section: Histological Analysismentioning

confidence: 99%

Preparation and In Vivo Study of Porous Titanium–Polyglycolide Composite

et al. 2016

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Porous materials show low Young s moduli and excellent bonding to living bone. However, the strength of such materials is often insufcient in the initial stage of implantation. Thus, the objective of this study was to increase the strength of porous titanium by lling the pores with polyglycolide (PGA), a biodegradable plastic. PGA powder was prepared via the thermal decomposition of sodium chloroacetate at 433 K. The PGA was then introduced into the pores of porous Ti (porosity: 60%) using two methods: (i) centrifugal packing and heating and (ii) heat injection. In the latter method, almost all pores were lled by PGA; the lling fraction was measured to be 65-85% regardless of the injection temperature. When the pores in the porous Ti were lled with PGA, the compressive strength increased drastically from 40 to 100 MPa. The increased strength is comparable to that of cortical bone. In addition, the strength increased with increasing injection temperature. In an animal test, unfavourable autopsy ndings, such as suppuration, bleeding, and hyperplasia of the connective tissue, could not be con rmed in rats and no bone was observed in the pores of the Ti-PGA composite. Decomposition of PGA lowered the surrounding pH, it was found to inhibit bone formation in the pores of the porous Ti. It is important to control the decomposition rate of PGA.

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Physical properties and enzymatic hydrolysis of poly(l-lactide)–CaCO3 composites

Cited by 34 publications

References 32 publications

Preparation and Enzymatic Degradation of Porous Crosslinked Polylactides of Biomass Origin

Preparation and Enzymatic Degradation of Porous Crosslinked Polylactides of Biomass Origin

Fabrication of Porous 3-D Structure from Poly(L-lactide)-based Nanocomposite Foam via Enzymatic Degradation

Preparation and In Vivo Study of Porous Titanium–Polyglycolide Composite

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