Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles

Marras, Alexander E.; Campagna, Trinity R.; Vieregg, Jeffrey; Tirrell, Matthew

doi:10.1021/acs.macromol.1c00743

Cited by 28 publications

(53 citation statements)

References 61 publications

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“…Recently, Marras et al. examined the scaling relationships for spherical PCMs formed by hydrophilic block copolymers and ssDNA. , By utilizing a combination of SAXS, TEM, and light scattering techniques, quantitative scaling exponents were determined that describe the PCM core radius, corona thickness, and aggregation number in terms of the block copolymer and DNA chain lengths. The experimentally determined scaling laws also compared well to previously reported PCM data, illustrating their excellent predictive power.…”

Section: Perspectivesmentioning

confidence: 99%

Nucleic Acids Based Polyelectrolyte Complexes: Their Complexation Mechanism, Morphology, and Stability

Kim

Lee

2021

Chem. Mater.

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Nucleic acids are a special class of negatively charged polymers, and they can complex with cationic small molecules and polymers to form polyelectrolyte complexes of rich morphology. The initial application focuses on gene delivery and typically involves the complexation of DNA with cationic surfactants and homopolymers.Recent research progress has extended to the complexation of nucleic acids with cationic block copolymers and ionic liquids, leading to the observation of unique morphology and stability characteristics and opening up opportunities for new application development. In this perspective article, we review the current understanding on the complexation behavior of nucleic acids with cationic species. We begin by discussing the phase behavior of DNA complexation with cationic surfactants and homopolymers. We then cover the more recent topic of nucleic acids interaction with cationic block copolymers and present the morphology and stability of complex micelles formed using both amphiphilic and hydrophilic block catiomers. Lastly, we examine DNA binding to ionic liquids and introduce new material applications involving ionic liquid stabilized DNA. We conclude the perspective by discussing a number of remaining challenges and future research topics in this exciting field.

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Section: Perspectivesmentioning

confidence: 99%

Nucleic Acids Based Polyelectrolyte Complexes: Their Complexation Mechanism, Morphology, and Stability

Kim

Lee

2021

Chem. Mater.

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“…As a special case of polyelectrolyte-polyelectrolyte materials, also diblock copolymers and triblock copolymers with polyelectrolyte blocks have been used for electrostatic self-assembly. Here, oppositely charged polyelectrolyte blocks attach to each other, forming the insoluble interior of a micelle, while an uncharged hydrophilic block forms the corona of the micelle-like structure, which allows for the formation of stable and well-defined micelle-like complexes in solution ( Chollakup et al, 2010 ; Tsitsilianis et al, 2000 ; Voets et al, 2006a ; Voets et al, 2006b ; Voets et al, 2009 ; van der Kooij et al, 2012 ; Yan et al, 2008a ; Yan et al, 2008b ; Wang et al, 2010 ; Wang J. et al, 2019 ; Zhou et al, 2019 ; Procházka et al, 1996 ; Srivastava et al, 2020 ; Marras et al, 2021 ). Cohen Stuart et al investigated various systems of these so-called polyelectrolyte complex micelles (PCMs) which form a variety of defined structures.…”

Section: Spontaneous Electrostatic Self-assemblymentioning

confidence: 99%

Functional Nano-Objects by Electrostatic Self-Assembly: Structure, Switching, and Photocatalysis

2022

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The design of functional nano-objects by electrostatic self-assembly in solution signifies an emerging field with great potential. More specifically, the targeted combination of electrostatic interaction with other effects and interactions, such as the positioning of charges on stiff building blocks, the use of additional amphiphilic, π−π stacking building blocks, or polyelectrolytes with certain architectures, have recently promulgated electrostatic self-assembly to a principle for versatile defined structure formation. A large variety of architectures from spheres over rods and hollow spheres to networks in the size range of a few tenths to a few hundred nanometers can be formed. This review discusses the state-of-the-art of different approaches of nano-object formation by electrostatic self-assembly against the backdrop of corresponding solid materials and assemblies formed by other non-covalent interactions. In this regard, particularly promising is the facile formation of triggerable structures, i.e. size and shape switching through light, as well as the use of electrostatically assembled nano-objects for improved photocatalysis and the possible solar energy conversion in the future. Lately, this new field is eliciting an increasing amount of understanding; insights and limitations thereof are addressed in this article. Special emphasis is placed on the interconnection of molecular building block structures and the resulting nanoscale architecture via the key of thermodynamics.

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“…The micelle corona forms a protective layer around the micelle core and prevents micelle coalescence. 10 In this way, micelles with specific polymer aggregation numbers and sizes of typically 10 to 100 nm are formed 11–13 that can protect their core components from external components. Their protective properties as well as their well-defined small size makes these DNA complex coacervate core micelles promising DNA-based medicine delivery tools.…”

Section: Introductionmentioning

confidence: 99%