Physical solid-state properties and dissolution of sustained-release matrices of polyvinylacetate

Novoa, Gelsys Ananay Gonzalez; Heinämäki, Jyrki; Mirza, Sabir; Antikainen, Osmo; Colarte, Antonio Iraizoz; Paz, Alberto Suzarte; Yliruusi, Jouko

doi:10.1016/j.ejpb.2004.07.012

Cited by 56 publications

(19 citation statements)

References 14 publications

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“…Furthermore, from Figure 4 and Table 3, it can be seen that increasing PVP percentage from 9 to 29% causes a remarkable increase in release rate and in dissolution efficiency (from 27.5 to 76.7%) for matrix-tablets prepared from co-spray dried products. Therefore, these results are in agreement with those reported by Novoa et al 20 , although the exponent n (Table 3) is not exceeding the value 0.45, which corresponds to Fickian diffusion, and show the possibility of reducing release rate without alteration of the release mechanism for matrix tablets Table 1) and one physical mixture containing drug and Kollidon SR at 1:2 weight ratio (PM formula 5, Table 2). Table 3.…”

Section: Characterization Of Matrix Tabletssupporting

confidence: 91%

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Al-Zoubi

Al-obaidi

Tashtoush

et al. 2015

Drug Development and Industrial Pharmacy

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In this work, aqueous diltiazem HCl and polyvinyl-pyrrolidone (PVP) solutions were mixed with Kollicoat SR 30D and spray dried to microparticles of different drug:excipient ratio and PVP content. Co-spray dried products and physical mixtures of drug, Kollidon SR and PVP were tableted. Spray drying process, co-spray dried products and compressibility/compactability of co-spray dried and physical mixtures, as well as drug release and water uptake of matrix-tablets was evaluated. Simple power equation fitted drug release and water uptake (R(2) > 0.909 and 0.938, respectively) and correlations between them were examined. Co-spray dried products with PVP content lower than in physical mixtures result in slower release, while at equal PVP content (19 and 29% w/w of excipient) in similar release (f2 > 50). Increase of PVP content increases release rate and co-spray drying might be an alternative, when physical mixing is inadequate. Co-spray dried products show better compressibility/compatibility but higher stickiness to the die-wall compared to physical mixtures. SEM observations and comparison of release and swelling showed that distribution of tableted component affects only the swelling, while PVP content for both co-spray dried and physical mixes is major reason for release alterations and an aid for drug release control.

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Section: Characterization Of Matrix Tabletssupporting

confidence: 91%

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Al-Zoubi

Al-obaidi

Tashtoush

et al. 2015

Drug Development and Industrial Pharmacy

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“…Poly(vinyl acetate) (PVAc), a biocompatible and biodegradable (owing to the hydrolyzable groups in the side chain) polymer, has also been used in biomedical applications, including drug and cell carriers, and tissue engineering. 26,27 PVA is a well-known biocompatible and nontoxic polymer. Biocompatibility of PVA is due to both its compatibility with tissue and blood (plasma proteins), which has been widely reported.…”

Section: Introductionmentioning

confidence: 99%

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

141

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The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

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“…Vinyl polymers such as polyvinylacetate (PVAc), polyvinylalcohol (PVA) and PVP are widely used in the development of oral drug delivery products [1]. PVAc is a homopolymer synthesized from vinylacetate monomer via a free-radical polymerization technique.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the electrospinning conditions for preparation of nanofibers from polyvinylacetate (PVAc) in ethanol solvent

Park

Lee

Bea

2008

Journal of Industrial and Engineering Chemistry

113

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Physical solid-state properties and dissolution of sustained-release matrices of polyvinylacetate

Cited by 56 publications

References 14 publications

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Optimization of the electrospinning conditions for preparation of nanofibers from polyvinylacetate (PVAc) in ethanol solvent

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