Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres

Acosta, Niuris; Sánchez, Elisa; Calderón, Laura; Córdoba-Díaz, Manuel; Córdoba-Díaz, Damián; Dom, Senne; Heras, Ángeles

doi:10.3390/md13095901

Cited by 42 publications

(19 citation statements)

References 30 publications

(28 reference statements)

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“…In addition, the intensity of the chitosan peak at 8.1° increased with addition of CNC, which indicates that the presence of CNC increases the ordering of chitosan chains upon drying . Incorporating GPE did not affect crystalline structures of the films, which agrees with previous finding that incorporation of the olive leaf extract into the chitosan microspheres did not affect the amorphous structure …”

Section: Resultssupporting

confidence: 90%

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Chitosan nanocomposite films incorporating cellulose nanocrystals and grape pomace extracts

Willis

Jordan

et al. 2018

Packag Technol Sci

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Chitosan nanocomposite films incorporating grape pomace extract (GPE), either Cabernet Franc (CF; a red variety) or Viognier (a white variety), and cellulose nanocrystal (CNC) were prepared using a solvent casting method. Mechanical properties, water vapour permeability, color and opacity, crystalline structure, thermal properties, total phenolic content, and antioxidant activity of the films were characterized. Incorporating CNC alone significantly (P < .05) increased tensile strength of the films and decreased their percent elongation at break and water vapour permeability. Grape pomace extract had an opposite effect on mechanical properties by decreasing tensile strength but increasing percent elongation at break. Film color was mainly influenced by the presence and type of GPE. Films containing CF extract exhibited the darkest appearance with increased reddish and bluish hues. Addition of CNC significantly increased film opacity and the alignment of chitosan chains, while the effect of GPE was not significant. Thermal analysis showed that chitosan and CNC were partially miscible and that the addition of CNC did not significantly change decomposition temperature of the films. Incorporation of GPE significantly (P < .05) increase total phenolic content and antioxidant activity. Films containing CF had higher DPPH• radical scavenging capacity than their counterparts with Viognier. Film incorporating both CNC and CF shows greater potential for food packaging application because of a combination of improved physical properties and high antioxidant activity.

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Section: Resultssupporting

confidence: 90%

“…45 Incorporating GPE did not affect crystalline structures of the films, which agrees with previous finding that incorporation of the olive leaf extract into the chitosan microspheres did not affect the amorphous structure. 46…”

Section: Color and Opacity Of Filmsmentioning

confidence: 99%

Chitosan nanocomposite films incorporating cellulose nanocrystals and grape pomace extracts

Willis

Jordan

et al. 2018

Packag Technol Sci

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“…Wide varieties of industries use chitosan for different applications. Chitosan has potential for drug-delivery [3,13,14] or as a source of biomaterials to generate nanofibers or nanoparticles [15,16,17]. This review describes the mode of action of chitosan in fungi and plants.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Chitosan Interactions with Fungi and Plants

López-Moya

Suarez-Fernandez

López-Llorca

2019

IJMS

200

108

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Chitosan is a versatile compound with multiple biotechnological applications. This polymer inhibits clinically important human fungal pathogens under the same carbon and nitrogen status as in blood. Chitosan permeabilises their high-fluidity plasma membrane and increases production of intracellular oxygen species (ROS). Conversely, chitosan is compatible with mammalian cell lines as well as with biocontrol fungi (BCF). BCF resistant to chitosan have low-fluidity membranes and high glucan/chitin ratios in their cell walls. Recent studies illustrate molecular and physiological basis of chitosan-root interactions. Chitosan induces auxin accumulation in Arabidopsis roots. This polymer causes overexpression of tryptophan-dependent auxin biosynthesis pathway. It also blocks auxin translocation in roots. Chitosan is a plant defense modulator. Endophytes and fungal pathogens evade plant immunity converting chitin into chitosan. LysM effectors shield chitin and protect fungal cell walls from plant chitinases. These enzymes together with fungal chitin deacetylases, chitosanases and effectors play determinant roles during fungal colonization of plants. This review describes chitosan mode of action (cell and gene targets) in fungi and plants. This knowledge will help to develop chitosan for agrobiotechnological and medical applications.

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“…Chitin exhibits low solubility and it is quite difficult to handle. On the contrary, chitosan is soluble in acid aqueous solutions and can easily produce different conformations such as micro, nano and milli particles, films, scaffolds and fibres among others [ 20 ]. Oligosaccharides and some chitin and chitosan derivatives are water soluble at physiological pH and exhibit improved or even new properties.…”

Section: Chitin Chitosan and Their Derivatives In Cosmetics And Cmentioning

confidence: 99%

Cosmetics and Cosmeceutical Applications of Chitin, Chitosan and Their Derivatives

et al. 2018

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Marine resources are well recognized for their biologically active substances with great potential applications in the cosmeceutical industry. Among the different compounds with a marine origin, chitin and its deacetylated derivative—chitosan—are of great interest to the cosmeceutical industry due to their unique biological and technological properties. In this review, we explore the different functional roles of chitosan as a skin care and hair care ingredient, as an oral hygiene agent and as a carrier for active compounds, among others. The importance of the physico-chemical properties of the polymer in its use in cosmetics are particularly highlighted. Moreover, we analyse the market perspectives of this polymer and the presence in the market of chitosan-based products.

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Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres

Cited by 42 publications

References 30 publications

Chitosan nanocomposite films incorporating cellulose nanocrystals and grape pomace extracts

Chitosan nanocomposite films incorporating cellulose nanocrystals and grape pomace extracts

Molecular Mechanisms of Chitosan Interactions with Fungi and Plants

Cosmetics and Cosmeceutical Applications of Chitin, Chitosan and Their Derivatives

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