1962
DOI: 10.1016/s0021-9258(18)60292-3
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Physical Studies of Lysozyme

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Cited by 367 publications
(114 citation statements)
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“…some evidence for the dimerization of lysozyme in solution at high pH (Sophianopoulos, Rhodes, Holcomb & Van Holde 1962). The present crystal form can be grown at high pH as well as at pH 4-7 (Sarma 1965) and it seems reasonable to suggest that the dimers in solution make use of the same contact areas as have been found in the crystal.…”
Section: Contacts Between Neighbouring Moleculessupporting
confidence: 59%
See 1 more Smart Citation
“…some evidence for the dimerization of lysozyme in solution at high pH (Sophianopoulos, Rhodes, Holcomb & Van Holde 1962). The present crystal form can be grown at high pH as well as at pH 4-7 (Sarma 1965) and it seems reasonable to suggest that the dimers in solution make use of the same contact areas as have been found in the crystal.…”
Section: Contacts Between Neighbouring Moleculessupporting
confidence: 59%
“…Crystals of hen egg-white lysozyme, grown a t pH 4*7 (Alderton & Fevold 1946), are tetragonal with a = b = 79*1 A, c = 37*9 A, s Ballantyre & Galvin 1948; Blake, Fenn, North, Phillips & Poljak 1962). Each of the eight asymmetric units in the cell comprises a single lysozyme molecule, molecular weight about 14600, together with 1 M sodium chloride solution which constitutes some 33*5 % of the weight of the crystal (Steinrauf 1959).…”
mentioning
confidence: 99%
“…The experimental system studied is composed of the protein lysozyme (diameter s ¼ 3.4 nm) 19 suspended in a pH 7.0 sodium phosphate buffer at an ionic strength of 0.6 M. Solubilities, f sat , for lysozyme were measured by allowing crystals to grow in suspensions held at a fixed temperature for several months. The solubility is taken as the steady state protein concentration in solution above the crystals.…”
Section: Methodsmentioning
confidence: 99%
“…First, we analyze the second virial coefficient as such, for this will point toward a way of dealing with the osmotic pressure at nonzero concentrations. We focus on experiments with lysozyme, a protein which is reasonably spherical and has been well studied for a long time [15].…”
Section: Introductionmentioning
confidence: 99%