Physical Surface Modification of Carbon-Nanotube/Polydimethylsiloxane Composite Electrodes for High-Sensitivity DNA Detection

Moon, Junga; Jiang, Huaide; Lee, Eun-Cheol

doi:10.3390/nano11102661

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…More recently, carbon-based nanomaterials have become a popular coating for molecular detection devices because of its ability to achieve a greater measurement specificity. For example, a composite electrode made of CNTs and PDMS were implemented into the original ITO protocol to aid in the specific detection of DNA (Moon et al, 2021). Compared to that of standard gold (Au) electrodes, the fabrication process of MWCNT/PDMS was more efficient, and therefore, more commercializable.…”

Section: Molecular Detectionmentioning

confidence: 99%

Emerging nanomaterials to enhance electrochemical impedance spectroscopy for biomedical applications

Arianpour

Wang

et al. 2023

Front. Mater.

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Over the last few decades, electrical impedance-based sensors have been investigated for clinical translation to detect changes in tissue conductivities, including cardiac output and pulmonary function. Recently, electrochemical impedance spectroscopy (EIS) provides metabolic measurements that occur at the electrode-tissue interface, and the 3-D EIS can be reconstructed to generate electrical impedance tomography (EIT) for detecting the impedimetric properties of the vascular wall or fatty liver disease. In both EIS and EIT applications, the electrochemical properties of the interface electrodes are essential to address the signal-to-noise ratio or sensitivity of measurements in the biological environment. To enhance the conductive properties, we will survey a series of carbon-based nanomaterials as the emerging candidates for coating the electrodes of bioimpedance sensors. In this review, we will provide a theoretical background on impedance-based measurements and highlight the current state of EIS and EIT, including their applications for cancer screening and detection of vulnerable atherosclerotic plaques. Next, we will focus on the strengths of different nanomaterials when used as an electrode coating to optimize charge transfer across the electric double layers and to enhance measurement sensitivity. We will also identify some unmet clinical needs, such as the ability to adapt to different hemodynamic conditions and blood vessel geometries, that can be realized by the novel biomaterials for the future EIS-based sensors.

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Section: Molecular Detectionmentioning

confidence: 99%

Emerging nanomaterials to enhance electrochemical impedance spectroscopy for biomedical applications

Arianpour

Wang

et al. 2023

Front. Mater.

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“…Therefore, it can be expected that polymer materials doped with carbon nanoparticles will find application in medicine and biology as drugs, antimicrobial agents [16,17], and inhibitors (catalysts) of enzymatic processes. An important area of application of fullerene composites in a polymer matrix is the development of biological sensors [18][19][20] and bacterial biosensors [16,21,22] based on the electrically conductive and corrosive properties of fullerenes [23,24].…”

Section: Introductionmentioning

confidence: 99%

Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties

et al. 2021

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A technology for producing a nanocomposite based on the borsiloxane polymer and chemically unmodified fullerenes has been developed. Nanocomposites containing 0.001, 0.01, and 0.1 wt% fullerene molecules have been created. It has been shown that the nanocomposite with any content of fullerene molecules did not lose the main rheological properties of borsiloxane and is capable of structural self-healing. The resulting nanomaterial is capable of generating reactive oxygen species (ROS) such as hydrogen peroxide and hydroxyl radicals in light. The rate of ROS generation increases with an increase in the concentration of fullerene molecules. In the absence of light, the nanocomposite exhibits antioxidant properties. The severity of antioxidant properties is also associated with the concentration of fullerene molecules in the polymer. It has been shown that the nanocomposite upon exposure to visible light leads to the formation of long-lived reactive protein species, and is also the reason for the appearance of such a key biomarker of oxidative stress as 8-oxoguanine in DNA. The intensity of the process increases with an increase in the concentration of fullerene molecules. In the dark, the polymer exhibits weak protective properties. It was found that under the action of light, the nanocomposite exhibits significant bacteriostatic properties, and the severity of these properties depends on the concentration of fullerene molecules. Moreover, it was found that bacterial cells adhere to the surfaces of the nanocomposite, and the nanocomposite can detach bacterial cells not only from the surfaces, but also from wetted substrates. The ability to capture bacterial cells is primarily associated with the properties of the polymer; they are weakly affected by both visible light and fullerene molecules. The nanocomposite is non-toxic to eukaryotic cells, the surface of the nanocomposite is suitable for eukaryotic cells for colonization. Due to the combination of self-healing properties, low cytotoxicity, and the presence of bacteriostatic properties, the nanocomposite can be used as a reusable dry disinfectant, as well as a material used in prosthetics.

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“…Moon et al [ 3 ] employed physical rather than chemical modifications of carbon-nanotube/polydimethylsiloxane composite electrode surfaces to enhance the detection of biomolecules such as DNA. By dip-coating the electrodes with functionalized multi-wall carbon nanotubes, the detection limit could be increased by a factor of more than 1000 compared with the original composite, paving the way towards lower detection limits of biosensor systems.…”

mentioning

confidence: 99%

Special Issue “Novel Structural and Functional Material Properties Enabled by Nanocomposite Design”

Eckert

Kiener

2023

Nanomaterials

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Physical Surface Modification of Carbon-Nanotube/Polydimethylsiloxane Composite Electrodes for High-Sensitivity DNA Detection

Cited by 6 publications

References 48 publications

Emerging nanomaterials to enhance electrochemical impedance spectroscopy for biomedical applications

Emerging nanomaterials to enhance electrochemical impedance spectroscopy for biomedical applications

Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties

Special Issue “Novel Structural and Functional Material Properties Enabled by Nanocomposite Design”

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