Physico-topological simulation of a transmission X-ray tube (TRT) with inductionally heated thermionic cathode is presented, taking into account physical properties of functional elements and their design. Modeling is based on physical fundamentals for vacuum electronics and electrodynamics using ComSol. The distributions of electromagnetic fields, currents, temperature, and trajectories of thermoelectrons were calculated. The analysis of electron trajectories made it possible to optimize TRT topology and design.