Physical training decreases waist circumference in postmenopausal borderline overweight women

Bergström, Ingrid; Lombardo, Cira; Brinck, Jonas

doi:10.1080/00016340802695942

Cited by 28 publications

(31 citation statements)

References 34 publications

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“…Our study offers several strengths relative to other RCTs in postmenopausal women that compared exercise with a control group (22)(23)(24)(25)(26)(27). Second only to the DREW trial (n ¼ 421; ref.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, 5 comparable RCTs have described the isolated effect of long-term exercise on circulating CRP, IL-6, or TNF-a levels exclusively in cancer-free postmenopausal women (22)(23)(24)(25)(26)(27). These 5 studies were 6 (22, 27) or 12 months (23)(24)(25)(26) in duration involving mainly aerobic exercise. All 5 RCTs examined CRP changes whereas 2 RCTs also measured IL-6 and/or TNF-a levels (22,25).…”

Section: Discussionmentioning

confidence: 99%

“…In developing a disease prevention strategy, however, it is important to understand in whom exercise is most beneficial, at what dose, and the underlying biologic mechanisms involved. Very few randomized controlled trials (RCT) of exercise, independent of any dietary intervention, have studied these questions exclusively in postmenopausal women (22)(23)(24)(25)(26)(27), and findings were conflicting. Postmenopausal women represent a population subgroup that may respond differently to exercise given that female sex and older age have been associated with higher CRP levels (28) that may be partly related to a general increase in intraabdominal adiposity that occurs after menopause (29).…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Marker Changes in a Yearlong Randomized Exercise Intervention Trial among Postmenopausal Women

Friedenreich

Neilson

Woolcott

et al. 2012

Cancer Prevention Research

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Chronic low-grade inflammation is a possible risk factor for cancer that may be modifiable with long-term exercise. Very few randomized controlled trials (RCT) have studied the isolated effects of exercise on lowgrade inflammation exclusively in postmenopausal women. The Alberta Physical Activity and Breast Cancer Prevention Trial, a 2-armed RCT in healthy postmenopausal women, examined how 1 year of moderate to vigorous aerobic exercise, compared with usual inactivity, influenced circulating inflammatory markers. Baseline, 6-month, and 12-month serum was analyzed by direct chemiluminescent immunoassays to measure high sensitivity C-reactive protein (CRP) and ELISAs to measure interleukin 6 (IL-6) and TNF-a. Intention to treat analyses were conducted with linear mixed models. Statistically significant differences in CRP were observed over 12 months for exercisers versus controls (treatment effect ratio ¼ 0.87, 95% CI ¼ 0.79-0.96, P ¼ 0.005), but not in IL-6 or TNF-a. A statistically significant trend (P trend ¼ 0.021) of decreasing CRP with increasing exercise adherence and stronger intervention effects on CRP in women with higher baseline physical fitness (P heterogeneity ¼ 0.040) was found. The intervention effect on CRP became statistically nonsignificant with adjustment for dietary fiber intake change and seemed to be mediated by fat loss. Low-grade inflammation may be lowered with exercise, but confounding by dietary intake occurred and should be considered in future studies. Further trials are needed to corroborate our findings about the optimal dose of exercise required to lower CRP levels and effect modification of CRP changes by levels of body fatness and fitness. Cancer Prev Res; 5(1); 98-108. Ó2011 AACR.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflammatory Marker Changes in a Yearlong Randomized Exercise Intervention Trial among Postmenopausal Women

Friedenreich

Neilson

Woolcott

et al. 2012

Cancer Prevention Research

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“…Also, exercise type could be relevant, e.g., aerobic may be preferable to resistance exercise with respect to weight loss [18] and lowering total abdominal fat [21•] in overweight adults. Indeed, the largest exercise RCTs of moderate-vigorous aerobic exercise in healthy postmenopausal women all showed decreases in intra-abdominal fat [22, 23] or waist circumference [24•, 25, 26] and overall body fat [22, 23, 24•, 25]. …”

Section: Epidemiologic Evidence Relating Exercise To Proposed Biomarkersmentioning

confidence: 99%

The Influence of Energetic Factors on Biomarkers of Postmenopausal Breast Cancer Risk

2013

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Strong and consistent evidence exists that physical activity reduces breast cancer risk by 10-25 %, and several proposed biologic mechanisms have now been investigated in randomized, controlled, exercise intervention trials. Leading hypothesized mechanisms relating to postmenopausal breast cancer include adiposity, endogenous sex hormones, insulin resistance, and chronic low-grade inflammation. In addition, other pathways are emerging as potentially important, including those involving oxidative stress and telomere length, global DNA hypomethylation, immune function, and vitamin D exposure. Recent exercise trials in overweight/obese postmenopausal women implicate weight loss as a mechanism whereby exercise induces favorable changes in circulating estradiol levels and other biomarkers as well. Still it is plausible that some exercise-induced biomarker changes do not require loss of body fat, whereas others depend on abdominal fat loss. We highlight the latest findings from randomized, controlled trials of healthy postmenopausal women, relating exercise to proposed biomarkers for postmenopausal breast cancer risk.

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“…Recent studies show that resistance training can help prevent the process of osteoporosis by reducing the activity of NFκB. In this regard, Bergström et al showed that a one-year period of exercise significantly decreased the activity of NFκB and RANKL in postmenopausal women (40). It seems that both resistance training and aerobic exercise have similar impact on the osteoclastic process, so that the mechanical pressure of resistance training on bones changes the osteoclastic process of NFκB (39, 47, and 50).…”

Section: Conflict Of Interestmentioning

confidence: 99%

Simultaneous Effect of Resistance Training and Portulace Oleraceal Supplementation on Some Biochemical Markers of Bone Dynamics in Women with Type II Diabetes

Ziadloo¹,

Farzanegi²,

Habibian³

2016

mljgoums

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Background and Objective: Osteoporosis is one of the complications of diabetes. The aim of this study was to determine the impact of resistance training along with Portulaca oleracea supplementation on OPG and NFκB levels (bone markers) in women with type II diabetes.Methods: Overall, 28 women with type II diabetes (44 to 60 years old) were randomly and equally assigned into four groups (supplement, training, training-supplement and control). An eight-week resistance training program (three one-hour sessions per week with one repetition maximum) was performed using three types of bands with different resistances, at 40-50% intensity and 50-70% maximum heart rate. P. oleracea seeds were supplemented daily (7.5 grams mixed in yogurt) for eight weeks. The data was analyzed using descriptive statistics, paired t-test and ANOVA.Results: After 8 weeks, OPG and NFκB levels in the three groups of supplement, training and training-supplement increased and decreased, respectively. The highest change in both variables was observed in the training-supplement group. Moreover, the level of these two variables in the training-supplement group had significant difference with the controls and other groups (P=0.000).Conclusion: As a non-pharmacological therapeutic approach, the regular resistance training and P. oleracea supplementation can increase bone formation markers and reduce bone resorption in women with type II diabetes.

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Physical training decreases waist circumference in postmenopausal borderline overweight women

Abstract: A moderate physical exercise program for healthy postmenopausal women during one year reduced the waist circumference in a training intensity dependent manner.

Cited by 28 publications

References 34 publications

Inflammatory Marker Changes in a Yearlong Randomized Exercise Intervention Trial among Postmenopausal Women

Inflammatory Marker Changes in a Yearlong Randomized Exercise Intervention Trial among Postmenopausal Women

The Influence of Energetic Factors on Biomarkers of Postmenopausal Breast Cancer Risk

Simultaneous Effect of Resistance Training and Portulace Oleraceal Supplementation on Some Biochemical Markers of Bone Dynamics in Women with Type II Diabetes

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