Physical Training Increases Muscle GLUT4 Protein and mRNA in Patients With NIDDM

Dela, Flemming; Ploug, Thorkil; Handberg, Aase; Petersen, Lone Nørgaard; Larsen, Jørgen Falck; Mikines, K. J.; Galbo, H.

doi:10.2337/diab.43.7.862

Cited by 197 publications

(114 citation statements)

References 10 publications

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“…Aerobic training is known to increase insulin sensitivity [16], and we found a strong relationship between physical fitness and clustered risk in both cross-sectional studies. Also, clustered risk tracked strongly from adolescence to young adulthood.…”

Section: Discussionsupporting

confidence: 53%

The relationship between physical fitness and clustered risk, and tracking of clustered risk from adolescence to young adulthood: eight years follow-up in the Danish Youth and Sport Study

Andersen

Hasselstrøm

Grønfeldt

et al. 2004

Int J Behav Nutr Phys Act

158

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IntroductionCardiovascular disease (CVD) is usually caused by high levels of many risk factors simultaneously over many years. Therefore, it is of great interest to study if subjects stay within rank order over time in both the biological risk factors and the behaviour that influences these risk factors. Many studies have described stability (tracking) in single risk factors, especially in children where hard endpoints are lacking, but few have analysed tracking in clustered risk.MethodsTwo examinations were conducted 8 years apart. The first time, 133 males and 172 females were 16–19 years of age. Eight years later, 98 males and 137 females participated. They were each time ranked into quartiles by sex in four CVD risk factors all related to the metabolic syndrome. Risk factors were the ratio between total cholesterol and HDL, triglyceride, systolic BP and body fat. The upper quartile was defined as being at risk, and if a subject had two or more risk factors, he/she was defined as a case (15–20 % of the subjects). Odds ratios (OR) for being a case was calculated between quartiles of fitness in both cross-sectional studies. The stability of combined risk was calculated as the OR between cases and non-cases at the first examination to be a case at the second examination.ResultsORs for having two or more risk factors between quartiles of fitness were 3.1, 3.8 and 4.9 for quartiles two to four, respectively. At the second examination, OR were 0.7, 3.5 and 4.9, respectively. The probability for "a case" at the first examination to be "a case" at the second was 6.0.ConclusionsThe relationship between an exposure like physical fitness and CVD risk factors is much stronger when clustering of risk factors are analysed compared to the relationship to single risk factors. The stability over time in multiple risk factors analysed together is strong. This relationship should be seen in the light of moderate or weak tracking of single risk factors, and is strong evidence for early intervention in children where risk factors cluster.

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Section: Discussionsupporting

confidence: 53%

The relationship between physical fitness and clustered risk, and tracking of clustered risk from adolescence to young adulthood: eight years follow-up in the Danish Youth and Sport Study

Andersen

Hasselstrøm

Grønfeldt

et al. 2004

Int J Behav Nutr Phys Act

158

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“…These improvements in glucose disposal are therefore indicative of the muscle contraction-mediated effects on metabolism. The evidence base indicates that short-term aerobic training can increase myocellular GLUT4 protein content (45), endothelial lipoprotein lipase activity (46,47), and intracellular lipid metabolism (6); improve hepatic cholesterol metabolism; and reverse cholesterol transport (48). This mechanistic literature provides some insight into the elevated peripheral tissue glucose uptake, the decrease in circulating triglycerides, and the more favorable cholesterol subfractions seen after acute training in this study.…”

Section: Discussionmentioning

confidence: 89%

Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans

Solomon¹,

Haus²,

Kelly³

et al. 2009

The American Journal of Clinical Nutrition

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“…Classic alterations in skeletal muscle phenotype following physical training include improved fatigue resistance, enhanced aerobic capacity and greater insulin sensitivity [9,23,25,35,36]. The significance of an individual's ability to adapt to exercise training may ultimately influence multiple risk factors important for long term cardiovascular health [5].…”

Section: Discussionmentioning

confidence: 99%

Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans

et al. 2005

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Background: Regular exercise reduces cardiovascular and metabolic disease partly through improved aerobic fitness. The determinants of exercise-induced gains in aerobic fitness in humans are not known. We have demonstrated that over 500 genes are activated in response to endurance-exercise training, including modulation of muscle extracellular matrix (ECM) genes. Real-time quantitative PCR, which is essential for the characterization of lower abundance genes, was used to examine 15 ECM genes potentially relevant for endurance-exercise adaptation. Twenty-four sedentary male subjects undertook six weeks of high-intensity aerobic cycle training with muscle biopsies being obtained both before and 24 h after training. Subjects were ranked based on improvement in aerobic fitness, and two cohorts were formed (n = 8 per group): the highresponder group (HRG; peak rate of oxygen consumption increased by +0.71 ± 0.1 L min -1 ; p < 0.0001) while the low-responder group (LRG; peak rate of oxygen consumption did not change, +0.17 ± 0.1 L min -1 , ns). ECM genes profiled included the angiopoietin 1 and related genes (angiopoietin 2, tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1) and 2 (TIE2), vascular endothelial growth factor (VEGF) and related receptors (VEGF receptor 1, VEGF receptor 2 and

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Physical Training Increases Muscle GLUT4 Protein and mRNA in Patients With NIDDM

Cited by 197 publications

References 10 publications

The relationship between physical fitness and clustered risk, and tracking of clustered risk from adolescence to young adulthood: eight years follow-up in the Danish Youth and Sport Study

The relationship between physical fitness and clustered risk, and tracking of clustered risk from adolescence to young adulthood: eight years follow-up in the Danish Youth and Sport Study

Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans

Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans

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