Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fasligand system in patients with chronic heart failure

Adamopoulos, Stamatis; Parissis, John; Karatzas, Dimitrios; Kroupis, Christos; Georgiadis, Michael C.; Karavolias, George; Paraskevaidis, John; Koniavitou, K.; Coats, Andrew J.S.; Kremastinos, Dimitrios Th.

doi:10.1016/s0735-1097(01)01795-8

Cited by 219 publications

(68 citation statements)

References 41 publications

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“…Exercise of varying intensities may improve wellbeing and combat some of the basal increase in inflammation often associated with obesity, T2DM and cardiovascular disease [39–43]. The present investigation failed to identify any measurable changes in circulatory inflammatory proteins at rest following 2 weeks of HIIT in group 1 or group 2.…”

Section: Discussioncontrasting

confidence: 63%

An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men

et al. 2017

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ᅟBoth sprint interval training (SIT) and high-intensity intermittent training (HIIT) have been described as time-efficient strategies for inducing favourable metabolic and cardiorespiratory adaptations in healthy and diseased participants.BackgroundTo date, little attention has been given to profiling the potential health benefits of HIIT or modified HIIT training within overweight and obese cohorts with particular focus on inflammation. Within this pilot trial, we tested the hypothesis that 6 sessions of HIIT performed over 2 weeks with 1–2 days’ rest would improve aerobic capacity, glucose metabolism and inflammatory profile in an overweight and obese male cohort. Additionally, we profiled the potential health benefits of 4 HIIT sessions performed over the same period.Methods18 overweight or obese males (BMI = 31.2 ± 3.6; V̇O2 = 30.3 ± 4.4 ml.kg.min-1) were studied before and 72 h after HIIT. Training sessions consisted of 10 x 1 min intervals at 90% HRpeak separated by 1 min recovery periods. Exercise was performed either 6 (group 1, n = 8) or 4 (group 2, n = 10) times over a 2 week period.ResultsAfter training no changes were detected from baseline for body composition, aerobic capacity, glucose metabolism or inflammatory profile (p > 0.05) in either group.ConclusionBoth 6 and 4 sessions of HIIT performed over a 2-week period are ineffective in improving selected health markers within an overweight and obese cohort.Trial registrationThis trial reports data from human participants and was retrospectively registered on 22/02/2017 with the ISRCTN registry, trial number ISRCTN90672085.

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Section: Discussioncontrasting

confidence: 63%

An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men

et al. 2017

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“…The reduction in plasma TNF- α , IL-6, and their receptors has been demonstrated in aerobically trained HF patients [98], suggesting an attenuation in the chronic inflammatory condition mediated by a regulation in peripheral inflammatory response [95, 98]. Similarly, the association between aerobic and resistance ET decreased the concentration of TNF- α receptors I and II in patients with HF [99].…”

Section: Aerobic Exercise Training As Therapymentioning

confidence: 99%

Role of Exercise Training on Autonomic Changes and Inflammatory Profile Induced by Myocardial Infarction

Rodrigues

Lira

Consolim‐Colombo

et al. 2014

Mediators of Inflammation

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The cardiovascular autonomic imbalance in patients after myocardial infarction (MI) provides a significant increase in mortality rate, and seems to precede metabolic, hormonal, and immunological changes. Moreover, the reduction in the parasympathetic function has been associated with inflammatory response in different pathological conditions. Over the years, most of the studies have indicated the exercise training (ET) as an important nonpharmacological tool in the management of autonomic dysfunction and reduction in inflammatory profile after a myocardial infarction. In this work, we reviewed the effects of ET on autonomic imbalance after MI, and its consequences, particularly, in the post-MI inflammatory profile. Clinical and experimental evidence regarding relationship between alterations in autonomic regulation and local or systemic inflammation response after MI were also discussed.

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“…It is well accepted that exercise restores proWles of inXammatory cytokines and enhances the eVects of antiatherosclerotic agents (Adamopoulos et al 2002;Goldhammer et al 2005;Teixeira de Lemos et al 2009). Moreover, exercise has also been veriWed to increase HRV and BRS, lower blood pressure and reduce cardiovascular autonomic dysfunction in rats (Bertagnolli et al 2006;Souza et al 2007;Tezini et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve

et al. 2009

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The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M(2)) receptors expression in the heart was investigated in Sprague-Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M(2) receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M(2) receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M(2) receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M(2) receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.

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Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fasligand system in patients with chronic heart failure

Abstract: Physical training reduces plasma levels of proinflammatory cytokines and the sFas/sFasL system in patients with CHF. These immunomodulatory effects may be related to the training-induced improvement in functional status of patients with CHF.

Cited by 219 publications

References 41 publications

An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men

An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men

Role of Exercise Training on Autonomic Changes and Inflammatory Profile Induced by Myocardial Infarction

Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve

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