Physical training status determines oxidative stress and redox changes in response to an acute aerobic exercise

Seifi-Skishahr, Farnaz; Damirchi, Arsalan; Farjaminezhad, Manoochehr; Babaei, Parvin

doi:10.1016/j.freeradbiomed.2016.04.089

Cited by 6 publications

(7 citation statements)

References 33 publications

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“…Considering the fact that GSH/GSSG in blood plasma represents a clinical measure of oxidative stress, reduction of GSH/GSSG indicates a shift in redox balance towards a more oxidizing environment [30]. The finding is in agreement with the previous study by Seifi-Skishahr et al [31]. These authors found that plasma GSH/GSSG showed a sharp significant reduction immediately after one session of aerobic exercise in subjects with different physical training status, indicating the occurrence of exercise-induced oxidative stress.…”

Section: The Effects Of Exercise Training On Biochemical Parameterssupporting

confidence: 92%

“…GSH is found in all extracellular biological fluids, and here we chose plasma as an extracellular fluid circulating between body cells and exchanging oxidative biomarkers. However, according to the study from Seifi-Skishahr et al [31], the changes in erythrocyte GSH/ GSSG are not parallel with plasma GSH/GSSG, which suggests that the plasma redox biomarker might not accurately reflect tissue redox status compared with erythrocyte biomarkers. One of limitations of the current study is lack of data on erythrocyte oxidative stress biomarkers that is suggested for future studies.…”

Section: Limitationsmentioning

confidence: 96%

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The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes

Zhou

Zeng

Lyu

et al. 2021

PhysInt

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AimLimited investigations on metabolic responses to exercise training in female adolescent volleyball athletes exist. The aim of this study was to obtain serum and urine metabolite markers in female adolescent volleyball athletes within 2-week strength-endurance training using a metabolomics approach coupled with biochemical analysis, which would be potential biomarkers for evaluating the physiological state of athletes.MethodsTwelve female adolescent volleyball athletes were recruited for 2-week strength-endurance training. Differential serum and urine metabolic profiles between the pre- and post-training group were obtained on gas chromatography coupled to mass spectrometry (GC-MS) and data subsequently underwent orthogonal partial least-squares analysis (OPLS).ResultsStrength-endurance training exerted a significant influence on the athletes' serum and urine metabolic profiles. The changed metabolites were primarily involved in energy metabolism, lipid metabolism and amino acids metabolism. Results support the hypothesis that female athletes displayed an increased propensity to oxidize lipids as the major energy source. Exposure to strength-endurance training also led to a significant increase in cortisol, but a decrease in testosterone, indicating disordered hormone adjustment. Exercise-induced oxidative stress occurred, as was evidenced by the decrease in reduced glutathione, and increases in blood malondialdehyde and oxidized glutathione. Since the muscle damage markers creatine kinase and lactate dehydrogenase did not show significant changes, the training might not cause cell membrane damage and the athletes did not cross the adaptive injury level.ConclusionBy measurement of endogenous metabolites, the metabolomics study has the potential to reveal the global physiological changes in response to exercise training.

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Section: The Effects Of Exercise Training On Biochemical Parameterssupporting

confidence: 92%

Section: Limitationsmentioning

confidence: 96%

The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes

Zhou

Zeng

Lyu

et al. 2021

PhysInt

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“…Training status has specifically been shown to effect OS responses to acute exercise . While the majority of literature has investigated and reported chronic anti‐oxidative responses of aerobic exercise, some have reported improved antioxidant status from resistance and anaerobic training as well . Resistance exercise has also been shown to reduce OS associated with chronic diseases, including Parkinson's disease and obesity .…”

Section: Discussionmentioning

confidence: 99%

Effect of carbohydrate restriction on oxidative stress response to high‐intensity resistance exercise

et al. 2019

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Ketogenic diets consisting of >70% dietary intake from lipids may induce favorable shifts in the redox environment such as reduced markers of oxidative stress (OS). However, a diet with such low dietary carbohydrate intake is difficult to sustain for long periods of time. This study investigated the effects of a low‐carbohydrate, high‐fat (LCHF) diet on markers of OS before and after high‐intensity resistance exercise (HIRE). The HIRE protocol involved five rounds of back squat, deadlift, and bench press completed in respective order and in a descending ladder (10, 8, 6, 4, 2 repetitions) with minimal to no rest. The LCHF diet was 15 days of >50% of calories from fat, ≥25% of calories from protein, and ≤25% of calories from carbohydrates. Blood was sampled before exercise, immediately post‐exercise, and 60 minutes post‐exercise and analyzed for total antioxidant capacity (TAC), tumor necrosis factor‐α (TNF‐α), malondialdehyde (MDA), superoxide dismutase (SOD), and glucose. The exercise protocol increased (P < .05) plasma levels of glucose, TNF‐α, and MDA. There was a significant increase in MDA from pre to post exercise following the western diet but not the LCHF condition. The LCHF diet did not significantly impact any other blood marker of OS.

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“…However, physical endeavor of high intensity causes multiple changes which overstretch mechanisms of adaptation, eventually causing oxidative stress and inflammation and resulting in deterioration of physical parameters (8). Results of research on the topic of marathon effect on free radicals production and oxidative stress are contradictory and non-conclusive (9); while in other research has been shown that ultra-marathon does not cause significant changes in redox balance (10).…”

Section: Introductionmentioning

confidence: 94%

Ten Marathons in Ten Days: Effects on Biochemical Parameters and Redox Balance – Case Report

Pesic

Srejović

Stefanović

et al. 2019

Serbian Journal of Experimental and Clinical Research

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Production of free radicals and oxidative damage during physical activity is a topic that is intensively studied and paid a lot of attention, first of all in professional sports. Marathon is categorized as extremely demanding sports discipline, as it induces high energy consumption and also requires special mental self-control. We presented cases of two athletes of different age, who have been on dissimilar level of sports readiness, and also had various approach to physical activity and exercise. During 10 days they ran out 10 marathons, partly on a flat terrain, and partly on hilly, which produced different level of effort in conquering the terrain. Also, both athletes had complex supplementation scheme in order to prevent electrolyte imbalance and excessive production of free radicals. Blood samples were taken in the morning and immediately after the end of the marathon. Measured oxidative stress biomarkers changed without a noticeable pattern, but these changes did not vary greatly among themselves. Catalase activity in both marathon runners was higher after marathon almost after every race for 10 days. On the other hand, amount of reduced glutathione was lower after marathon in both athletes in the same manner. Based on the obtained results we can conclude that adequate supplementation could have crucial role in prevention of oxidative damage.

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Physical training status determines oxidative stress and redox changes in response to an acute aerobic exercise

Cited by 6 publications

References 33 publications

The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes

The effect of strength-endurance training on serum and urine metabolic profiles of female adolescent volleyball athletes

Effect of carbohydrate restriction on oxidative stress response to high‐intensity resistance exercise

Ten Marathons in Ten Days: Effects on Biochemical Parameters and Redox Balance – Case Report

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