This study aimed to characterise two little-known woods and discuss their potential to replace those heavily exploited in Cameroon's forests. Amouk (Detarium macrocarpum) and Dabema (Piptadeniastrum africanum) were characterised for their physical and mechanical properties. Density, shrinkage, desorption kinetics, shear strength, tensile strength and modulus of elasticity (MOE) in compression and flexion were determined. A Weibull analysis was performed to predict their failure. It was found that Amouk and Dabéma can be classified as medium-heavy wood with low shrinkage and desorption, following Midilli's empirical model. The physical and mechanical characterisations show that the density, strength and MOE parameters of the woods are close to each other and enable them to be classified as medium-strength woods. The probability of failure in compression follows Weibull's law. These woods can, therefore, be used in structural applications such as construction, replacing common woods.