Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Ciolacu, Diana; Rudaz, Cyrielle; Vasilescu, Marius; Budtova, Tatiana

doi:10.1016/j.carbpol.2016.05.084

Cited by 102 publications

(55 citation statements)

References 40 publications

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“…Therefore, many chemicals including carbonyl generating agents, carbonyl diimidazole, N , N′ ‐disuccinimidyl carbonate, N ‐hydroxysuccinimidyl chloroformate, aldehyde groups like formaldehyde and glutaraldehyde, as well as oxiranes and epoxides such as epichlorohydrin, are generally used as coupling agents to bind hydroxyl groups with amine groups . Although these chemicals can be toxic materials for living organisms with direct use, they can be used in the preparation of biomaterials that will come in contact with living organisms without significantly affecting toxicity as the end products are used after further modification . Amongst the coupling agents, ECH is generally preferred because it can be readily removed from the resultant materials and shows high yield even at low amounts of use and demonstrates good biocompatibility of the end‐products .…”

Section: Introductionmentioning

confidence: 99%

“…Although these chemicals can be toxic materials for living organisms with direct use, they can be used in the preparation of biomaterials that will come in contact with living organisms without significantly affecting toxicity as the end products are used after further modification . Amongst the coupling agents, ECH is generally preferred because it can be readily removed from the resultant materials and shows high yield even at low amounts of use and demonstrates good biocompatibility of the end‐products . Furthermore, ECH is commonly utilized as an coupling agent for removal of bacterial endotoxins, in waste water treatment, drug delivery systems, enzyme immobilization, food packaging, wound healing and many other applications .…”

Section: Introductionmentioning

confidence: 99%

“…Amongst the coupling agents, ECH is generally preferred because it can be readily removed from the resultant materials and shows high yield even at low amounts of use and demonstrates good biocompatibility of the end‐products . Furthermore, ECH is commonly utilized as an coupling agent for removal of bacterial endotoxins, in waste water treatment, drug delivery systems, enzyme immobilization, food packaging, wound healing and many other applications . Once ECH anchorage is accomplished on the surface, then the epoxide surface can readily react with amine groups in basic media such as PEI .…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Suner

Şahiner

Akçalı

et al. 2019

J of Applied Polymer Sci

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Halloysite nanotube (HNT), a natural clay, was modified with branched polyethyleneimine (PEI) to form PEI‐HNT using epichlorohydrin (ECH) as coupling agent, then protonated with HCl to obtain H‐PEI‐HNTs providing [NH3]+[Cl]− functionality for potential antimicrobial properties. Upon PEI modification, zeta potential value of HNTs was increased to +37.3 mV from −34.5 mV and to +41.1 mV for H‐PEI‐HNTs. Only 1.87 wt % H‐element in HNT was increased to 3.03 wt % upon PEI modification along with newly generated elements of N and C at 2.99 and 9.93 wt %, respectively. Moreover, ionic liquid (IL) forms of HNTs with [NH3]+[N(CN)2]−, [NH3]+[PF6]− and [NH3]+[BF4]− functionality were generated via anion exchange of H‐PEI‐HNTs with sodium dicyanamide (SDC), ammonium hexafluorophosphate (AHFP), and sodium tetrafluoroborate (STFB). The antimicrobial properties of the modified, protonated, and IL forms of HNTs were determined via macro dilution, diffusion and agar screening tests against Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 10145, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538 strains, and Candida albicans ATCC 10231 strains. It was found that H‐PEI‐HNTs possesses potent antimicrobial effect compared with the other forms of HNTs with 2–4 mg mL−1 MIC and 8–16 mg mL−1 MBC values via the macro dilution method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48352.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Suner

Şahiner

Akçalı

et al. 2019

J of Applied Polymer Sci

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“…On the other hand, the chemical cross-linking process is a permanent junction formed by covalent bonds, with a relatively strong and stable connection between diverse functional groups introduced by using different cross-linking agents. 6,7 Over the past few decades, polymeric materials have greatly influenced the development of new technologies, the expansion of science borders and the advancement of modern medicine, due to the fact that polymers are easily processed and chemically modified to match the requirements of specific biomedical applications. Different polymers of natural and synthetic origin or natural-synthetic hybrid polymers featuring different architectures and consequently, desired chemical, physical and mechanical properties, are used in different fields, such as medicine, 8 engineering, 9,10 agriculture.…”

Section: Introductionmentioning

confidence: 99%

Cellulose-Based Hydrogels in Tissue Engineering Applications

Rusu¹,

Ciolacu²,

Simionescu³

2019

Cellulose Chem. Technol.

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In the last decade, the field of medicine is at the epicentre of recent technological growth and innovation, while major changes have occurred in areas such as tissue engineering, in terms of concepts, knowledge and materials. In this regard, hydrogels are one of the materials of the future, due to their outstanding adaptability, which makes their applications almost endless. These are three-dimensional polymeric networks able to display biomimetic properties, a characteristic that is considered optimal to deliver bioactive principles and engineer injured tissues. Due to their high water content and compatibility with cells, hydrogels may infiltrate into specific or non-specific binding with cell receptors. In addition, with increased concerns about environmental impacts and the emergent request for new eco-friendly materials, researchers are focusing particularly on the application of natural polymer-based hydrogels in the biomedical engineering field, in order to reach non-toxicity, abundance of starting materials, novel features and biomimetic properties. Cellulose and cellulose derivatives represent a class of biopolymers that exhibit the particular capability to participate in different biomedical applications due to their excellent biocompatibility and biodegradability, tunable properties and low cost. This review focuses on the key aspects and recent advances regarding the design, properties and applications of hydrogels based on cellulose and its derivatives, in the broad area of tissue engineering.

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“…Cryogels have superior properties such as fast swelling-shrinkage, high mechanical strength and elasticity (Sengel et al, 2017;Suner et al, 2019;Tavsanli and Okay., 2020). Because of these innate properties, cryogels are commonly used in biomedical fields including tissue engineering, drug carrier systems, immunotherapy as well as having applications in environmental use such as separation and purification (Sahiner and Demirci, 2016;Sahiner et al, 2017;Topuz and Uyar, 2017;Ciolacu et al, 2016;Hixon et al, 2017;Akilbekova et al, 2018;Guo et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Dextran Cryogels and Some of Their Applications

Ari

Şahiner

2019

Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In this study, dextran (DEX) cryogels were prepared using 50% divinyl sulfone (DVS) crosslinker based on the repeating unit of DEX, under cryogenic conditions via cryogellation technique. It was shown that DEX cryogels can be used as column fillers to remove toxic substances such as organic dye, methylene blue (MB), pesticide, and paraquat (PQ) which are harmful to the environment and human health. The maximum absorption capacity of 15 mg DEX cryogels was determined as 10.69±0.14 mg/g using 5 mL of 100 ppm MB dye in about seven minutes, and as 2.87±0.33 mg/g from 5 mL of 40 ppm PQ pesticide in about ten minutes. The reusability of DEX cryogel for MB was also examined. In the consecutive use of DEX cryogel weighing ~30 mg, initially cryogel absorbed 6.43±0.15 mg MB/g cryogel from 20 ppm 30 mL MB dye, but this value decreased to 4.71±0.48 mg MB/g cryogel after the fifth use. The same cryogel released the same amount of MB dye after the first use of 3.78±0.33 mg MB/g cryogel, but after the fifth use the release amount decreased to 0.92±0.38 mg MB/g cryogel upon treatment with 1 M 30 mL HCl solution. The adsorption kinetics of DEX cryogel for MB were also examined and the Langmuir isotherm model with a correlation coefficient of 0.9983 and the K L value of 0.36, representing the best fit amongst the other wellknown models such as the Freundlich isotherm, Temkin, Elovich and Dubinin-Radushkevich.Keywords: dextran cryogel, dye and pesticide removal, natural polymer, superporous/macro porous material. Şahiner ve Ari, 2019 Araştırma / Research 188 Dekstran Kriyojellerinin Hazırlanması ve Bunların Bazı Uygulamaları ÖzBu çalışmada, dekstran (DEX) kriyojeleri, tekrarlayan DEX birimine göre %50 divinil sülfon (DVS) çapraz bağlayıcı kullanılarak kriyojenik koşullar altında kriyojelasyon tekniği ile hazırlanmıştır. DEX kriyojellerinin çevreye ve insan sağlığına zararlı organik boya, metilen mavisi (MB), pestisit, parakuat (PQ) gibi toksik maddeleri uzaklaştırmak için kolon dolgu maddesi olarak kullanılabileceği gösterilmiştir. DEX kriyojelinin 15 mg'ı için maksimum absorpsiyon kapasitesine, MB için yaklaşık yedi dakikada 5 mL-100 ppm çözeltiden 10,69±0,14 mg/g, PQ için ise yaklaşık on dakikada 2,87±0,33 mg/g absorblayarak ulaşmıştır. DEX kriyojelinin MB için yeniden kullanılabilirliği de yapılmıştır. ~30 mg ağırlığındaki DEX kriyojelinin art arda kullanımında, başlangıçta 20 ppm, 30 mL olan MB çözeltisinden absorplanan miktar 6,43±0,15 mg MB/g kriyojel olarak hesaplanmış, bu değer beşinci kullanımdan sonra 4,71±0,48 mg MB/g kriyojel olarak hesaplanmıştır. MB absorplamış DEX kriyojeli ile yapılan salım çalışmalarında ilk kullanımda 3,78±0,33 mg MB/g kriyojel salmıştır, ancak beşinci kullanımdan sonra, salınan miktar, 1 M 30 mL HC1 ile muamele üzerine 0,92±0,38 mg MB/g kriyojel olarak hesaplanmıştır. DEX kriyojelinin MB için adsorpsiyon kinetiği de incelenmiş olunup, 0,9983 korelasyon katsayısı ve 0,36 K L değeri ile Freundlich, Temkin, Elovich ve Dubinin-Radushkevich izotermleri gibi diğer iyi bilinen modeller arasında en uygun...

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Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Cited by 102 publications

References 40 publications

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Cellulose-Based Hydrogels in Tissue Engineering Applications

Preparation of Dextran Cryogels and Some of Their Applications

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