Physically and chemically dual-crosslinked hydrogels with superior mechanical properties and self-healing behavior

Zhang, Xueqin; Zhang, Ruqing; Wu, Shu; Sun, Ying; Yang, Hong; Lin, Baoping

doi:10.1039/d0nj00348d

Cited by 26 publications

(13 citation statements)

References 40 publications

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“…will bring about high mechanical properties. 6 – 8 As well, high cross-linking density also favors dense structure and enhanced stiffness. It is worth noting that the fabrication approaches (in situ gelation, 9 electrospinning, 10 micropatterning, 11 3D bioprinting, 12 microfluidics, 13 etc.…”

Section: Introductionmentioning

confidence: 99%

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao

Duan

Yan

et al. 2021

Sig Transduct Target Ther

480

256

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Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) and influence cell signaling cascades and fate. In the past few decades, a plethora of pioneering studies have been implemented to explore the cell–hydrogel matrix interactions and figure out the underlying mechanisms, paving the way to the lab-to-clinic translation of hydrogel-based therapies. In this review, we first introduced the physicochemical properties of hydrogels and their fabrication approaches concisely. Subsequently, the comprehensive description and deep discussion were elucidated, wherein the influences of different hydrogels properties on cell behaviors and cellular signaling events were highlighted. These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganization, gene expression, and further cell biology modulation (e.g., spreading, migration, proliferation, lineage commitment, etc.). Based on them, current in vitro and in vivo hydrogel applications that mainly covered diseases models, various cell delivery protocols for tissue regeneration and disease therapy, smart drug carrier, bioimaging, biosensor, and conductive wearable/implantable biodevices, etc. were further summarized and discussed. More significantly, the clinical translation potential and trials of hydrogels were presented, accompanied with which the remaining challenges and future perspectives in this field were emphasized. Collectively, the comprehensive and deep insights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate cellular processes, which are available for providing significant indications for future hydrogel design and serving for a broad range of biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao

Duan

Yan

et al. 2021

Sig Transduct Target Ther

480

256

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“…of the lignin hydrogel. Fe 3+ in the lignin hydrogel leads to a significant increase in its conductivity (Figure c); in addition, the conductivity of the lignin hydrogel is further enhanced by (1) the excellent network structure, and thus, the ionic conducting paths, of the lignin hydrogel as a result of both covalent cross-linking (PEGDGE as a cross-linker) and noncovalent cross-linking (Fe 3+ chelation, hydrogen bonding) and (2) sulfonic groups in lignosulfonate that are easily hydrolyzed, consequently increasing the ionic conductivity. , Another function of effective Fe 3+ chelation is to seal off the hydrophilic groups present in the lignin hydrogel, such as phenolic hydroxyl, carboxylic, and sulfonic groups, rendering the resultant hydrogels hydrophobic and, consequently, nonstick to many surfaces, which improves the sensitivity of strain sensors. ,,− …”

Section: Resultsmentioning

confidence: 99%

Design of Fe³⁺-Rich, High-Conductivity Lignin Hydrogels for Supercapacitor and Sensor Applications

Mondal

et al. 2022

Biomacromolecules

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Preparation of natural polymer-based highly conductive hydrogels with tunable mechanical properties for applications in flexible electronics is still challenging. Herein, we report a facile method to prepare lignin-based Fe3+-rich, high-conductivity hydrogels via the following two-step process: (1) lignin hydrogels are prepared by cross-linking sulfonated lignin with poly(ethylene glycol) diglycidyl ether (PEGDGE) and (2) Fe3+ ions are impregnated into the lignin hydrogel by simply soaking in FeCl3. Benefiting from Fe3+ ion complexation with catechol groups and other functional groups in lignin, the resultant hydrogels exhibit unique properties, such as high conductivity (as high as 6.69 S·m–1) and excellent mechanical and hydrophobic properties. As a strain sensor, the as-prepared lignin hydrogel shows high sensitivity when detecting various human motions. With the flow of moist air, the Fe3+-rich lignin hydrogel generates an output voltage of 162.8 mV. The assembled supercapacitor of the hydrogel electrolyte demonstrates a high specific capacitance of 301.8 F·g–1, with a maximum energy density of 26.73 Wh·kg–1, a power density of 2.38 kW·kg–1, and a capacitance retention of 94.1% after 10 000 consecutive charge–discharge cycles. These results support the conclusion that lignin-based Fe3+-rich, high-conductivity hydrogels have promising applications in different fields, including sensors and supercapacitors, rendering a new platform for the value-added utilization of lignin.

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“…12,13 The possibility to design a crosslinking polymeric network at a molecular level by the incorporation of chemically functionalized nanofillers has given the opportunity to control the physical and chemical properties of nanocomposite hydrogels. 13,14…”

Section: Introductionmentioning

confidence: 99%

Insights into enzymatic degradation of physically crosslinked hydrogels anchored by functionalized carbon nanofillers

et al. 2022

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Physically and chemically dual-crosslinked hydrogels with superior mechanical properties and self-healing behavior

Abstract: Using SDS-C18 micelle as a physical crosslinker and SiPU as a multifunctional chemical crosslinker, a new type of dual-crosslinked self-healing hydrogel with excellent stretchability, strength and resilience was synthesized.

Cited by 26 publications

References 40 publications

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Design of Fe³⁺-Rich, High-Conductivity Lignin Hydrogels for Supercapacitor and Sensor Applications

Insights into enzymatic degradation of physically crosslinked hydrogels anchored by functionalized carbon nanofillers

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Physically and chemically dual-crosslinked hydrogels with superior mechanical properties and self-healing behavior

Abstract: Using SDS-C18 micelle as a physical crosslinker and SiPU as a multifunctional chemical crosslinker, a new type of dual-crosslinked self-healing hydrogel with excellent stretchability, strength and resilience was synthesized.

Cited by 26 publications

References 40 publications

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Design of Fe3+-Rich, High-Conductivity Lignin Hydrogels for Supercapacitor and Sensor Applications

Insights into enzymatic degradation of physically crosslinked hydrogels anchored by functionalized carbon nanofillers

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Design of Fe³⁺-Rich, High-Conductivity Lignin Hydrogels for Supercapacitor and Sensor Applications