Physically cross-linked pH-responsive chitosan-based hydrogels with enhanced mechanical performance for controlled drug delivery

Che, Yuju; Li, Dongping; Liu, Yulong; Ma, Qinglin; Tan, Yebang; Yue, Qinyan; Meng, Fanjun

doi:10.1039/c6ra16746b

Cited by 47 publications

(29 citation statements)

References 69 publications

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“…Cationic hydrogels have monomers with amine and amide groups such as AAm, dimethylaminoethyl methacrylate (DMAEMA), and 2‐(diethylamino)ethyl methacrylate (DEAEMA), and their copolymers. Hydrogels composed of biopolymers such as chitosan, alginate, albumin, and gelatin can also show pH responsivity and have excellent biocompatibility and biodegradability over their synthetic counterparts.…”

Section: Principlesmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

240

211

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Hydrogels, which are hydrophilic soft porous networks, are an important class of materials of broad relevance to bioanalytical chemistry, soft‐robotics, drug delivery, and regenerative medicine. Transformer hydrogels are micro‐ and mesostructured hydrogels that display a dramatic transformation of shape, form, or dimension with associated changes in function, due to engineered local variations such as in swelling or stiffness, in response to external controls or environmental stimuli. This review describes principles that can be utilized to fabricate transformer hydrogels such as by layering, patterning, or generating anisotropy, and gradients. Transformer hydrogels are classified based on their responsivity to different stimuli such as temperature, electromagnetic fields, chemicals, and biomolecules. A survey of the current research progress suggests applications of transformer hydrogels in biomimetics, soft robotics, microfluidics, tissue engineering, drug delivery, surgery, and biomedical engineering.

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Section: Principlesmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

240

211

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show abstract

“…In the last two decades, hydrogels, which usually possess inherent and excellent biocompatibility and biodegradability, have emerged as versatile biomaterials in various elds such as tissue engineering and cell biology. [1][2][3][4][5][6][7] Such cell-compatible hydrogels have been prepared using a variety of polymeric materials, which can broadly be divided into two categories according to their origins: natural materials such as hyaluronic acid [8][9][10][11][12] and chitosan, [13][14][15][16] or synthetic materials such as poly-(ethylene glycol) (PEG) and poly(vinyl alcohol) (PVA). [17][18][19][20][21][22][23][24] The naturally derived hydrogels show excellent biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Photodegradable hydrogels for external manipulation of cellular microenvironments with real-time monitoring

Zhang

et al. 2017

RSC Adv.

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“…The hydrogel network swelled more in simulated gastric fluid than simulated intestinal fluid, and also, the drugs were release more from the hydrogel in gastric pH condition than intestinal pH condition [128]. Physically cross-linked pH-responsive hydrogel with enhanced mechanical strength was developed from chitosan, acrylic acid, (2-dimethylamino) ethyl methacrylate via in situ free radical polymerization for controlled drug delivery of bovine serum albumin, and 5-fluorouracil in cancer therapy [129]. The potential drug carrier from pH-responsive hydrogel of carboxymethyl chitosan and PEG was developed using photo-induced synthesis, and the release of 5-fluorouracil from the hydrogel was investigated [130].…”

Section: Chemical Constituents Of Thermoresponsive Hydrogelmentioning

confidence: 99%

Stimuli-Responsive Hydrogels: An Interdisciplinary Overview

Chatterjee¹,

Chiu²

2019

Hydrogels - Smart Materials for Biomedical Applications

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Stimuli-responsive hydrogels formed by various natural and synthetic polymers are capable of showing distinctive changes in their properties with external stimuli like temperature, pH, light, ionic changes, and redox potential. Some hydrogels are developed to exhibit dual responsiveness with external stimuli such as pH and temperature. The stimuli-responsive hydrogels find a wide variety of biomedical applications including drug delivery, gene delivery, and tissue regeneration. The advanced functionalities can be imparted to textile materials by integrating stimuli-responsive hydrogels into them and stimuli-responsive hydrogels including thermoresponsive, pH-responsive, and dual-responsive improve moisture and water retention property, environmental responsiveness, esthetic appeal, display, and comfort of textiles. Stimuli-responsive hydrogels loaded with various kinds of drugs are applied for textile-based transdermal therapy as these hydrogels as drug carriers show controlled and sustained drug release. In this chapter, drug delivery and textile applications of thermoresponsive, pH-responsive, and dual-responsive (pH and temperature) hydrogels are discussed and analyzed.

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Physically cross-linked pH-responsive chitosan-based hydrogels with enhanced mechanical performance for controlled drug delivery

Abstract: A novel physically cross-linked pH-responsive hydrogel with enhanced mechanical performance was prepared from chitosan, acrylic acid and (2-dimethylamino) ethyl methacrylate via in situ free radical polymerization for controlled drug delivery.

Cited by 47 publications

References 69 publications

Transformer Hydrogels: A Review

Transformer Hydrogels: A Review

Photodegradable hydrogels for external manipulation of cellular microenvironments with real-time monitoring

Stimuli-Responsive Hydrogels: An Interdisciplinary Overview

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