Physician-Related Factors Involved in Patient Decisions to Enroll Onto Cancer Clinical Trials

Comis, Robert L.; Miller, Jon D.; Colaizzi, Diane D.; Kimmel, Linda G.

doi:10.1200/jop.0922001

Cited by 87 publications

(68 citation statements)

References 29 publications

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“…Among existing studies, few evaluated efficacy of their recruitment strategies and even fewer evaluated strategies targeting African Americans [19]. Specific recruitment strategies including media campaigns and church-based project sessions with enhanced recruitment letters and telephone calls have resulted in improved accrual [18].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study of a Culturally Targeted Video Intervention to Increase Participation of African American Patients in Cancer Clinical Trials

Banda

Libin²,

Wang³

et al. 2012

The Oncologist

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Disclosures:The authors indicated no financial relationships. ABSTRACTPurpose. Barriers to clinical trial participation among African American cancer patients are well characterized in the literature. Attitudinal barriers encompassing fear, distrust, and concerns about ethical misconduct are also well documented. To increase trial accrual, these attitudes must be adequately addressed, yet there remains a lack of targeted interventions toward this end. We developed a 15-minute culturally targeted video designed to impact six specific attitudes of African American cancer patients toward therapeutic trials. We conducted a pilot study to test in the first such intervention to increase intention to enroll.Patients and Methods. The primary study outcome was self-reported likelihood to participate in a therapeutic trial. Using a mixed methods approach, we developed the Conclusion. These data suggest utility of our video for increasing African American participation in clinical trials.

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Section: Discussionmentioning

confidence: 99%

A Pilot Study of a Culturally Targeted Video Intervention to Increase Participation of African American Patients in Cancer Clinical Trials

Banda

Libin²,

Wang³

et al. 2012

The Oncologist

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show abstract

“…1, 2). Although some barriers involve oncologists, health systems (3), or patient eligibility (4), another important cause of low enrollment may be lack of clinical trial awareness among cancer patients (5,6). Indeed, a survey of the general population found that 32% of adults would be "very willing" to participate in an oncologic clinical trial, and an additional 38% would be "inclined" to participate if provided more information (7).…”

Section: Introductionmentioning

confidence: 99%

Accessibility and Quality of Online Cancer-Related Clinical Trial Information for Naïve Searchers

Abel

Cronin

Earles

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although the Internet may help to increase cancer patients' awareness of clinical trials, little is known about the accessibility and quality of online clinical trial information. We simulated the experience of a na€ ve cancer patient without clinical trial knowledge by searching three popular search engines for treatment information for breast, lung, and prostate cancer, and myelodysplastic syndromes (MDS). Two coders independently evaluated website content for accessibility and quality. We screened 120 websites and identified 40 unique sites for analysis. Overall, 85% [95% confidence interval (CI), 70%-94%] of sites mentioned clinical trials on the landing page and 68% (51%-81%) included links to specific trials. Overall readability was poor. Approximately half of websites (36%-68%) included information on the potential benefits and risks of clinical trials and 40% provided information about when the site had been updated (25%-57%). Among sites with links to specific clinical trials, only 44% (25%-65%) provided an interactive interface that would allow patients to customize search results; breast (100%) and prostate (50%) sites were more interactive than lung (25%) and MDS (14%; P ¼ 0.007). Although cancer clinical trial information is widely available on the Internet, its quality is highly variable. Given the fact that many emerging cancer therapeutics are personalized based on disease or genomic characteristics, interactive web-based interfaces could serve as powerful vehicles to help patients locate appropriate clinical trials. Without enhanced efforts to ensure greater interactivity of cancer treatment websites, patient awareness of relevant clinical trials may remain low. Cancer Epidemiol Biomarkers Prev; 24(10); 1629-31. Ó2015 AACR.

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“…However, even in this literature, most research focuses on a single influence on, or a narrow aspect of, cancer patients' decision-making. These include the amount of control or involvement the patient wants in decision-making [8,13,17,18], the patient-provider relationship [19][20][21], assessments of quantity versus quality of life [7,9], or decisional satisfaction or regret [22,23].…”

Section: Introductionmentioning

confidence: 99%

Approaches to decision-making among late-stage melanoma patients: a multifactorial investigation

Garrett

Abramson

Rendle

et al. 2018

Support Care Cancer

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Purpose The treatment decisions of melanoma patients are poorly understood. Most research on cancer patient decision-making focuses on limited components of specific treatment decisions. This study aimed to holistically characterize late-stage melanoma patients' approaches to treatment decision-making in order to advance understanding of patient influences and supports. Methods (1) Exploratory analysis of longitudinal qualitative data to identify themes that characterize patient decision-making.(2) Pattern analysis of decision-making themes using an innovative method for visualizing qualitative data: a hierarchicallyclustered heatmap. Participants were 13 advanced melanoma patients at a large academic medical center. Results Exploratory analysis revealed eight themes. Heatmap analysis indicated two broad types of patient decision-makers. BReliant outsiders^relied on providers for medical information, demonstrated low involvement in decision-making, showed a low or later-in-care interest in clinical trials, and expressed altruistic motives. BActive insiders^accessed substantial medical information and expertise in their networks, consulted with other doctors, showed early and substantial interest in trials, demonstrated high involvement in decision-making, and employed multiple decision-making strategies. Conclusion We identified and characterized two distinct approaches to decision-making among patients with late-stage melanoma. These differences spanned a wide range of factors (e.g., behaviors, resources, motivations). Enhanced understanding of patients as decision-makers and the factors that shape their decision-making may help providers to better support patient understanding, improve patient-provider communication, and support shared decision-making.

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Physician-Related Factors Involved in Patient Decisions to Enroll Onto Cancer Clinical Trials

Cited by 87 publications

References 29 publications

A Pilot Study of a Culturally Targeted Video Intervention to Increase Participation of African American Patients in Cancer Clinical Trials

A Pilot Study of a Culturally Targeted Video Intervention to Increase Participation of African American Patients in Cancer Clinical Trials

Accessibility and Quality of Online Cancer-Related Clinical Trial Information for Naïve Searchers

Approaches to decision-making among late-stage melanoma patients: a multifactorial investigation

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