Depressive symptoms are common in medical trainees. In medical school and residency, studies estimate that approximately one-quarter of trainees may have depression or depressive symptoms, whereas only approximately one-sixth of such trainees seek mental health treatment (psychotherapy or pharmacotherapy). 1,2 The disconnect between depressive symptoms and help-seeking is disconcerting.In this article, we consider the well-established literature about medical students and residents with depression and depressive symptoms to understand the cultural barriers to help-seeking and to inform recommendations for attitudinal and structural changes. Depressive symptoms pose many overlapping challenges for trainees, including burnout, anxiety, and other common forms of distress that affect well-being and performance. Therefore, although our recommendations use depression as a starting point, they address barriers inherent in the overarching medical learning environment and the numerous challenges to the well-being of trainees.Stigma surrounding depression is deeply embedded in medicine. Despite a stated commitment to learner well-being, the culture of medicine continues to foster maladaptive perfectionism and silence for those with depression. [3][4][5] Although medical schools and residency programs have invested increasingly in wellness initiatives to support individual resilience, the learning environment itself is often the most substantial driver of distress. 3,6 Learners thus encounter mixed messages in their training; programs claim to value their well-being yet promote institutional policies and norms that reward self-sacrifice and increased productivity. Too often, help-seeking and time off are perceived as signs of weakness or poor work ethic. 3 Indeed, trainees report the most substantial barrier to their well-being is the lack of time or flexibility to attend to their physical and mental health needs. 3,7 Taken together, these experiences contribute to a learning environment that explicitly promotes self-care yet implicitly labels these actions as incompatible with the demands of medical practice.These mixed messages in medical training have material consequences. For example, across studies and personal accounts of depression, trainees report that they would hide a mental health diagnosis from others, fearing that help-seeking or receiving treatment would reflect poorly on them and jeopardize career prospects. [3][4][5] Medical students and residents report reluctance to access care, justifiably fearing that a record of mental health counseling or disability accommodations may compromise performance evaluations, success in the residency match, and employability. Institutional policies and legal protections notwithstanding, there is widespread doubt that personal health infor-VIEWPOINT