This study aims to determine anxiety and depression among health workers during the COVID-19 pandemic at Sanglah Hospital. Health workers in the front line on the COVID-19 pandemic are at high risk of being infected and at high risk of psychological impact. A descriptive study with a cross-sectional design and an online survey was conducted using the Beck Depression Inventory (BDI) instrument, and Beck Anxiety Depression (BAI). A total of 188 health workers were included. In this study, 3.7% of the participants had mild mood disorders, 1.1% had clinical depression and 0.5% had severe depression. Health workers who do not deal directly with COVID patients have a greater percentage of depression (2.04%) compared to those who have direct contact (1.4%). Statistically, occupation was significantly associated with the incidence of depression (p= 0.044). It was found that 18.1% has anxiety and the highest level of anxiety was found in nurses (20.8%) and also in participants who worked in the Non-COVID ward (24.5%). There is a statistical significance between anxiety and work station (p = 0.064).