Physico-Chemical Characterization and In Vitro Dissolution Assessment of Clonazepam—Cyclodextrins Inclusion Compounds

Abstract

Abstract. The objectives of this research were to prepare and characterize inclusion complexes of clonazepam with β-cyclodextrin and hydroxypropyl-β-cyclodextrin and to study the effect of complexation on the dissolution rate of clonazepam, a water-insoluble lipid-lowering drug. The phase-solubility profiles with both cyclodextrins were classified as A P -type, indicating the formation of 2:1 stoichiometric

Preparation and Evaluation of Orodispersible Tablets Containing <i>Hydroxylbutyl-β-Cyclodextrin-Simvastatin</i> Solid Dispersion

“…Methanol was evaporated under reduced pressure and the resultant solid dispersions were collected [10].…”

Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system

“…Hydroxypropyl-β-cyclodextrin (HPCD) is more watersoluble than the parent molecule, β-cyclodextrin, and has hydroxypropylester groups attached to the hydroxyl groups in position 2 (16). In addition, HPCD is known to form inclusion complexes with many compounds, which prevents the oxidation of oils and involatile flavors, and solubilizes insoluble compounds (17).…”

Performance evaluation of PAMAM dendrimer based simvastatin formulations

“…This inhibition leads to up-regulation of low-density lipoprotein (LDL) receptors and increase in catabolism of LDL cholesterol (Brown and Goldstein, 1986). Simvastatin is practically insoluble in water and hence poorly absorbed from the gastro-intestinal tract; oral bioavailability is less (<5%) (Martindale, 2005 Attempts have been made to deliver simvastatin by the use of lipids (as self-emulsifying drug delivery system) (Patil et al, 2007;Kang et al, 2004) and cyclodextrins (Patel and Patel, 2007;Yoshinari et al, 2007). But all the formulations suffer with some and other disadvantages.…”