Physico-chemical characterization and in vitro biological study of manganese doped β-tricalcium phosphate-based ceramics for bone regeneration applications

Arpak, Mehmet Can; Daglilar, Sibel; Kalkandelen, Cevriye; Balescu, Liliana-Marinela; Sasmazel, Hilal Turkoglu; Pasuk, Iuliana; Stan, George E.; Durukan, Kagan; Gunduz, Oguzhan

doi:10.1007/s41779-023-00889-5

Cited by 2 publications

(1 citation statement)

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“…With an aging population, changes in eating habits, diabetes and other health problems on the rise worldwide have caused great damage to our bones, leading to an increased incidence of bone damage or amputation [1][2][3]. As a result, many methods, including allografts, tissue engineering (TE) methods, and bioinert and bioactive implant materials, have been implemented to help patients regain limb use.…”

Section: Introductionmentioning

confidence: 99%

Influence of Ag and/or Sr Dopants on the Mechanical Properties and In Vitro Degradation of β-Tricalcium Phosphate-Based Ceramics

Che,

Sun,

et al. 2023

Materials

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β-tricalcium phosphate has good biodegradability and biocompatibility; it is widely perceived as a good material for treating bone deficiency. In this research, different contents of strontium (Sr) and silver (Ag) ion-doped β-tricalcium phosphate powders were prepared using the sol–gel method. After obtaining the best ratio of pore-forming agent and binder, the as-synthesized powders were sintered in a muffle for 5 h at 1000 °C to obtain the samples. Then, these samples were degraded in vitro in simulated body fluids. The samples were tested using a series of characterization methods before and after degradation. Results showed that the amount of Sr and/or Ag doping had an effect on the crystallinity and structural parameters of the samples. After degradation, though the compressive strength of these samples decreased overall, the compressive strength of the undoped samples was higher than that of the doped samples. Notably, apatite-like materials were observed on the surface of the samples. All the results indicate that Sr and/or Ag β-TCP has good osteogenesis and proper mechanical properties; it will be applied as a prospective biomaterial in the area of bone repair.

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Section: Introductionmentioning

confidence: 99%