Physico-chemical characterization of polysaccharide-coated nanoparticles

Lemarchand, Caroline; Gref, Ruxandra; Lesieur, Sylviane; Hommel, H.; Vacher, Béatrice; Besheer, Ahmed; Maeder, Karsten; Couvreur, Patrick

doi:10.1016/j.jconrel.2005.07.014

Cited by 54 publications

(39 citation statements)

References 32 publications

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“…The hydrophilic properties, the length, and charge from these polymers prevent the interaction of NPs with other biomolecules, including opsonins. 66,67 Besides, the degree of surface coverage is also an important consideration in design and preparation of NPs to prevent protein adsorption. 68,69 Among all polymers, PEG is the most commonly used polymer for NP surface modification.…”

Section: Systemic Circulation Time Of Npsmentioning

confidence: 99%

Protein corona: a new approach for nanomedicine design

Nguyen¹,

Lee²

2017

IJN

534

343

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After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and bioavailability. In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect. Validated correlative models for NP biological responses mainly based on protein corona fingerprints of NPs are more highly accurate than the models solely set up from NP properties. Based on these models, effectiveness as well as the toxicity of NPs can be predicted without in vivo tests, while novel cell receptors could be identified from prominent proteins which play important key roles in the models. The ungoverned protein adsorption onto NPs may have generally negative effects such as rapid clearance from the bloodstream, hindrance of targeting capacity, and induction of toxicity. In contrast, controlling protein adsorption by modifying NPs with diverse functional proteins or tailoring appropriate NPs which favor selective endogenous peptides and proteins will bring promising therapeutic benefits in drug delivery and targeted cancer treatment.

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Section: Systemic Circulation Time Of Npsmentioning

confidence: 99%

Protein corona: a new approach for nanomedicine design

Nguyen¹,

Lee²

2017

IJN

534

343

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“…Polysaccharides such as dextran, heparin, hyaluronic acid and chitosan have been shown to alter the opsonization process [66]. Heparin and dextran coating of poly(methyl methacrylate) nanoparticles has been shown to dramatically increase their in vivo circulation time compared to unmodified particles [67].…”

Section: Polysaccharidesmentioning

confidence: 99%

“…Increase in circulation time may have originated from decreased compliment activation for surface-modified particles [68]. Additionally, dextran coating of poly( -caprolactone) (PCL) particles led to reduced cell toxicity and protein adsorption [65,66], however, dextran-coating on nanoparticles also led to increased complement activation [65]. In addition to polymeric particles, polysaccharides have also been used to modify iron oxide particles and liposomes [10,64].…”

Section: Polysaccharidesmentioning

confidence: 99%

Factors that Control the Circulation Time of Nanoparticles in Blood: Challenges, Solutions and Future Prospects

Yoo

Chambers²,

Mitragotri³

2010

CPD

464

292

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Numerous types of nanoparticles are being designed for systemic and targeted drug delivery. However, keeping nanoparticles in blood for sufficiently long times so as to allow them to reach their therapeutic target is a major challenge. Upon administration into blood, nanoparticles are quickly opsonized and cleared by the macrophages, thereby limiting their circulation times. Surface-modification of nanoparticles by PEG was developed as the first strategy to prolong nanoparticles circulation. While PEGylation has helped prolong particle circulation, it has several limitations including transient nature of the effect and compromised particle-target interactions. Accordingly, several other approaches have been developed to prolong nanoparticle circulation in blood. These include modification with CD47, modulation of mechanical properties, engineering particle morphology and hitchhiking on red blood cells. In this review, we discuss the factors that affect nanoparticles circulation time and discuss recent progress in development of strategies to prolong circulation time.

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“…Therefore, for the case of microemulsions, nano-sized particles are of especial interest. Their formation and characterisation is developing very quickly and a great number of chemical methods has been elaborated [40][41][42][43][44] and various methods developed to determine the key properties, such as contact angle or surface energy, surface morphology, surface charge [45][46][47].…”

Section: Interfacial Energy Change By Particle Adsorptionmentioning

confidence: 99%