Physico-Chemical Characterization of the Inclusion Complexes Containing the Monoterpenes Camphor and 1,8-Cineol, Major Constituents of the Essential Oils of Croton conduplicatus, in β-Cyclodextrin

Abstract

Cyclodextrins (CDs) constitute a class of pharmaceutical excipients composed of D-glucopyranose units. Through the formation of inclusion complexes with CDs it is possible to administer nonpolar substances, such as monoterpenes, and evaluate their pharmacological activity. Considering the relevance of the discovery of new drugs, as well as the need to develop new pharmaceutical forms, this study aimed to develop inclusion complexes of monoterpenes contained in the essential oils of leaves and stem bark of Croton conduplicatus in β-cyclodextrin. The complexes were prepared and characterized by nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The analysis allowed us to conclude that there was in fact the formation of the inclusion complexes of camphor and 1,8-cineole in β-cyclodextrin, and the results were important to complement the studies being carried out in the area of pharmaceutical technology.

Anti-Melanoma Potential of Inclusion Complexes Containing Phyllacanthone in β-Cyclodextrin and Sulfobutyl-Ether-β-Cyclodextrin

“…The water solutions and the respective CDs were added to the mixtures and placed in a magnetic stirrer for 48 h. PHY/β-CD solution was lyophilized, while PHY/SB-E-β-CD solution was left in an oven with circulating air (at 45 °C) in a glass container for 48 hours. Physical mixtures were prepared in the same molar ratio, ground, and stored in a freezer until future analyses (Alves et al, 2019).…”