Physicochemical Analysis and Molecular Modeling of the Fosinoprilβ-Cyclodextrin Inclusion Complex

Abstract

This research investigates the interaction between fosinopril sodium (FOS) and beta-cyclodextrin (β-CD) in aqueous solution and in solid state, in order to prove the formation of an inclusion complex between the two components. The stoichiometry of the inclusion complex was found as 1 : 1 by employing continuous variation method in UV. The formation constant was calculated as 278.93 M−1using Benesi-Hildebrand equation. The kneaded product (KP) and the physical mixture (PM) were further experimentally examined, using FTIR, powder X-ray diffractometry, and thermal analysis. The results confirm that the physicochemical properties of the FOS/β-CD KP are different from FOS and that the kneading method leads to formation of solid state inclusion complex between FOS andβ-CD. Structural studies of the FOS/β-CD were carried out using molecular modeling techniques, in order to explain the complexation mechanism and the host-guest geometry.

Formation of inclusion compounds of (+)catechin with β-cyclodextrin in different complexation media: Spectral, thermal and antioxidant properties

“…Such a stage starts approximately at the endothermic peak located near 319 o C in Figure 8a, which is only 2 o C and 0.6 o C shifted from those believed to represent the melting point of β-CD in the studies performed by [13] and [41], respectively.…”

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex—Compatibility Study with Pharmaceutical Excipients

“…The solubility of the drug substance in the inclusion complex has been evaluated using the shake-flask method [ 18 , 19 , 52 ]. The drug concentration in saturated solution was assessed using UV spectrophotometry.…”

Complexation and physicochemical analysis of hydrophobic molecules of methyl jasmonate with Hydroxypropyl-β–Cyclodextrin

“…The highest temperature of the endothermic peak for the MeJa/HPβCΔ complex by M 4 (311.11 °C) supports it (see Figure 3b). A sharp fall of mass of all the examined compounds is observed in Figure 3a by increasing the temperature of the samples above 305 o C. According to Udrescu et al, (2014), the endothermic peak for free HPβCD at 301.67 o C in Figure 3b could be the melting point of the host. However, the loss of mass of HPβCD started at this temperature, in Figure 3a, may not be explained by this phenomenon, but only by the evaporation or thermal decomposition of this compound, as it was already inferred for another cyclodextrin (Junior et al, 2017).…”