Physicochemical and cytotoxicity analysis of green synthesis carbon dots for cell imaging

Fatahi, Zahra; Esfandiari, Neda; Ehtesabi, Hamide; Bagheri, Zeinab; Tavana, Hossein; Ranjbar, Zahra; Latifi, Hamid

doi:10.17179/excli2019-1465

Cited by 10 publications

(5 citation statements)

References 53 publications

(72 reference statements)

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“…On the other hand, many recent reviews have described several studies on the cytotoxic effect of CDs against different cell line models including, breast adenocarcinoma SKBR3, mouse embryonic fibroblast NIH-3T3, 253 human renal epithelial cells 293T, normal breast epithelial cells MCF-10A, normal human liver cells HL-7702 (L-02), normal human skin fibroblasts NSFbs, 241 human lung adenocarcinoma cells A549, human colorectal adenocarcinoma HCT-15 and others. 251 To date, several of these cytotoxic studies have shown that CDs did not alter cell viability.…”

Section: Carbon Dotsmentioning

confidence: 99%

Carbon dots for cancer nanomedicine: a bright future

et al. 2021

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Section: Carbon Dotsmentioning

confidence: 99%

Carbon dots for cancer nanomedicine: a bright future

et al. 2021

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“…One of the factors that makes CDs more popular as nanocarriers in therapeutic fields is their ability to surface functionalization [24][25][26]. This feature of CDs allows them to conjugate to various molecules, such as drugs, linkers, peptides, biomarkers, and so on for different applications like targeting drug delivery, bioimaging in targeted organs, biolabeling, and diseases detection along with its inhibition role against disorders [27].…”

Section: Introductionmentioning

confidence: 99%

Designing of a pH-activatable carbon dots as a luminescent nanoprobe for recognizing folate receptor-positive cancer cells

et al. 2021

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During recent years, cancer has been recognized as a well-known disorder all over the world. One of the important factors to tackle this problem better than past decades is early diagnosis that takes into practice by state-of-the-art visual equipment for detection cancer cells. Herein, in this research, we synthesized carbon dots with pH-dependent behavior from a green source by hydrothermal method with high quantum yield and blue fluorescence. Folic acid-conjugated carbon dots by an efficient and optimal conjugation method were set upped which determined cancer cells visually. These synthesized and conjugated nanoparticles entered into the cancer cells more comprehensive than normal cells by receptor-mediated endocytosis and could distinguish cancer cells from normal ones by fluorescence imaging. Ultimately, synthesized nanoparticles in this research can be considered as an efficient fluorescent nanoprobe for cancer pre-diagnosis.

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“…Aside from their low cost, facile synthesis, and ease of functionalization characteristics, CDs exhibited extraordinary fluorescence properties that have earned them the title “carbon nano lights”, and thus a variety of applications can be assigned for these nanomaterials. CDs have exceptional photochemical and physiochemical stability, , increased water dispersibility, intense and tunable photoluminescence, − excellent biocompatibility, , and minimal toxicity. CDs are classified into three distinct classes, namely, carbon nanodots (CNDs), which possess graphite or amorphous-like structure, graphene quantum dots (GQDs), which consist of one or 2–3 graphene layers, and polymer dots that consist of aggregated linear polymer chains around or inside a carbon core, respectively.…”

Section: Carbon Dots (Cds)mentioning

confidence: 99%

Carbon Dots and Their Polymeric Nanocomposites: Insight into Their Synthesis, Photoluminescence Mechanisms, and Recent Trends in Sensing Applications

Kar,

et al. 2024

ACS Omega

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Carbon dots (CDs), a novel class of carbon-based nanoparticles, have received a lot of interest recently due to their exceptional mechanical, chemical, and fluorescent properties, as well as their excellent photostability and biocompatibility. CDs' emission properties have already found a variety of potential applications, in which bioimaging and sensing are major highlights. It is widely acknowledged that CDs' fluorescence and surface conditions are closely linked. However, due to the structural complexity of CDs, the specific underlying process of their fluorescence is uncertain and yet to be explained. Because of their low toxicity, robust and wide optical absorption, high chemical stability, rapid transfer characteristics, and ease of modification, CDs have been recognized as promising carbon nanomaterials for a variety of sensing applications. Thus, following such outstanding properties of CDs, they have been mixed and imprinted onto different polymeric components to achieve a highly efficient nanocomposite with improved functional groups and properties. Here, in this review, various approaches and techniques for the preparation of polymer/CDs nanocomposites have been elaborated along with the individual characteristics of CDs. CDs/ polymer nanocomposites recently have been highly demanded for sensor applications. The insights from this review are detailed sensor applications of polymer/CDs nanocomposites especially for detection of different chemical and biological analytes such as metal ions, small organic molecules, and several contaminants.

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Physicochemical and cytotoxicity analysis of green synthesis carbon dots for cell imaging

Cited by 10 publications

References 53 publications

Carbon dots for cancer nanomedicine: a bright future

Carbon dots for cancer nanomedicine: a bright future

Designing of a pH-activatable carbon dots as a luminescent nanoprobe for recognizing folate receptor-positive cancer cells

Carbon Dots and Their Polymeric Nanocomposites: Insight into Their Synthesis, Photoluminescence Mechanisms, and Recent Trends in Sensing Applications

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