Physicochemical and drug release characteristics of acetylated starches of five Lagenaria siceraria cultivars

Kulkarni, Sameer D.; Sinha, Barij Nayan; Kumar, K. Jayaram

doi:10.1016/j.ijbiomac.2014.10.007

Cited by 11 publications

(1 citation statement)

References 35 publications

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“…In addition, the Carr's index provides an indirect measure of material fluidity. Generally, materials with CI up to 16% reveal good flow behaviour while those above 28% express poor powder flow and more cohesiveness [22]. CASG had CI value below 28% hence indicating good flow behaviour and low cohesiveness.…”

Section: Powder Characteristicsmentioning

confidence: 96%

Physicochemical and tablet properties of Cyperus alulatus rhizomes starch granules

Paramakrishnan

Jha

Kumar

2015

International Journal of Biological Macromolecules

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Section: Powder Characteristicsmentioning

confidence: 96%

Physicochemical and tablet properties of Cyperus alulatus rhizomes starch granules

Paramakrishnan

Jha

Kumar

2015

International Journal of Biological Macromolecules

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Effect of Soluble Potato Starch on the Pregelatinization Properties of Non‐Conventional Elephant Foot Yam Starch

Banerjee,

Kumar

2023

Starch Stärke

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In recent years, researchers have been exploring alternative sources of starch for drug delivery. Traditional options like corn, potato, and rice starches have been widely used, but sustainability concerns have prompted the investigation of nonconventional starches. Elephant foot yam starch, derived from an agricultural polymer, has gained popularity due to its wide availability. Starches are fundamentally unsuited for the majority of applications; they must be physically and/or chemically altered to maximize their advantages and/or minimize their drawbacks. Due to the chemical toxicity, starch modification is often done using physical techniques that are inexpensive. This study aims to evaluate the impact of elephant foot yam starch on the physicochemical properties and drug delivery of potato starch. Pregelatinization, a crucial process, is found to increase amylose content and improves starch flow properties, as confirmed by Fourier‐transform infrared spectroscopy analysis showing gelatinization in the mixture. Field emission scanning electron microscopy images reveal complete disruption of the starch granular structure after modification. Tablets made with a mixture of pregelatinized starches exhibit a slower drug release compared to those with pregelatinized starch alone. Notably, inclusion of potato starch in the mixture results in a more sustained drug release. Hence, modified starches have diverse applications for enhancing solubility of poorly soluble drugs.

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Synthesis and characterization of acetylated amylose and development of inclusion complexes with rifampicin

Ribeiro

Rocha

Soares

et al. 2017

Carbohydrate Polymers

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Amylose (AM) tends to form single helical inclusion complexes with suitable agents. These complexes are considered promising biomaterial carrier since the guest molecules can be released later, leading to many applications, especially in the pharmaceutical industry. Rifampicin (RIF) has long been recognized as an active drug against Mycobacterium tuberculosis, however, the administration of RIF in high dosages can originate unwanted side-effects. Due to the fact that the use of native amylose (AM) in the formation of complexes is limited by their low water solubility, it was acetylated with a medium degree of substitution (DS), allowing solubilizing (0.5gL) acetylated amylose (AMA) in water at neutral pH, in opposition to that observed with native amylose (trace solubility). The resulting acetylated amylose was characterized by means of Fourier Transform Infrared (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). FT-IR results indicated that the acetylation of anhydroglucose units of amylose corresponds to a low DS, whereas SEM results suggested that the smooth surfaces of amylose granules were changed into rougher surfaces after acetylation. Ultraviolet absorption spectroscopy (UV-vis) analysis confirmed the formation and allowed the quantification of both native (AM-RIF) and acetylated (AMA-RIF) amylose inclusion complexes. Their characterization in solution was performed by dynamic light scattering (DLS) and zeta potential (ZP) measurements. The average size of inclusion complexes as determined by DLS, ranged between 70 and 100nm. Besides, ZP analysis showed that both complexes are more stable in the presence of RIF. This study may lead to the development of an effective method for the preparation of amylose inclusion complexes, which is beneficial to their further application in drug delivery systems.

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Physicochemical and drug release characteristics of acetylated starches of five Lagenaria siceraria cultivars

Cited by 11 publications

References 35 publications

Physicochemical and tablet properties of Cyperus alulatus rhizomes starch granules

Physicochemical and tablet properties of Cyperus alulatus rhizomes starch granules

Effect of Soluble Potato Starch on the Pregelatinization Properties of Non‐Conventional Elephant Foot Yam Starch

Synthesis and characterization of acetylated amylose and development of inclusion complexes with rifampicin

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