Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery

Rade, Priyanka P.; Giram, Prabhanjan S.; Shitole, Ajinkya A.; Sharma, Neeti; Garnaik, Baijayantimala

doi:10.1007/s42765-021-00090-y

Cited by 29 publications

(18 citation statements)

References 33 publications

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“…On the other hand, as a typical zeolite imidazole skeleton material, ZIF-8 possesses a large-enough surface and plentiful active sites, as well as owns inverse electric charges against PMs, which favors trapping PMs by electrostatic interaction. Meanwhile, there are plenty of functional groups on the ZIF-8 surface, offering extra attraction for adsorption of PMs. − In virtue of the synergistic effect of the porous structure of the fiber membranes and the electrostatic interaction of ZIF-8, the ZIF-8@CCM-loaded composite nanofiber membrane exhibits superior PM removal performances (Figure S5) as compared with the reported literature.…”

Section: Resultsmentioning

confidence: 88%

Microfluidic Spinning of Metal–Organic Framework-Loaded Nanofibers toward High-Efficient Particulate Matter Removal and Antibacterial Filters

Dong,

Zhou,

Yong

et al. 2023

Ind. Eng. Chem. Res.

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Ambient particulate matter (PM) is one of the major pollutants in the atmosphere. Due to its small size, PM2.5 can penetrate the bronchial tubes and lungs, posing a serious threat to public health. Thus, methods allowing for the facile fabrication of efficient filtration materials are highly desirable. In this paper, we report a double-pore composite nanofiber membrane toward highly efficient and antibacterial filters. Specially, zeolite imidazole framework-8 nanoparticles coated with curcumin (ZIF-8@CCM) were prepared and spun with a polymer solution through a Y-channel via a microfluidic spinning strategy, generating a double-pore structure in the composite nanofiber. In virtue of the high porosity and permeability of the polymer nanofiber, as well as the large-enough surface and the abundant active sites of ZIF-8, the composite nanofiber membrane exhibits excellent PM removal performances. Outstanding filtration efficiencies of 99.41, 99.97, and 100% were achieved for PM0.5, PM2.5, and PM10, respectively. In addition, due to the antibacterial properties of ZIF-8 and CCM, the composite nanofiber membrane shows superior antibacterial properties. This work provides a facile pathway to fabricate a ZIF-8@CCM-loaded composite nanofiber membrane via microfluidic spinning, which will stimulate the design and development of versatile and high-performance filters.

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Section: Resultsmentioning

confidence: 88%

Microfluidic Spinning of Metal–Organic Framework-Loaded Nanofibers toward High-Efficient Particulate Matter Removal and Antibacterial Filters

Dong,

Zhou,

Yong

et al. 2023

Ind. Eng. Chem. Res.

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“…In Vitro Drug Release Profile. The in vitro drug release profile of the hydrogel MTZ-H2-G3 was evaluated in triplicate by immersing the hydrogel in 50 mL of the simulated physiological fluids, SGF (pH 1.2), SIF (pH 6.8), and SCF (pH 7.4) and incubated at 37 °C under constant shaking at 100 rpm [38]. The supernatant from each simulated physiological fluid was withdrawn at specified intervals and replaced with fresh simulated physiological fluids after each sample withdrawal.…”

Section: Characterizationmentioning

confidence: 99%

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties

Feyissa

Edossa

Bedasa

et al. 2023

International Journal of Polymer Science

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This research focused on preparing hydrogels with controlled drug release properties to control gastrointestinal tract bacterial infection. Chitosan (CS) and polyvinylpyrrolidone (PVP) were used as the base polymers, with the CS component crosslinked by glutaraldehyde for hydrogel preparation using the solution casting technique. The effect of varying glutaraldehyde content in the hydrogels was characterized by the extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4; the development of porosity; and gel fraction. Functional groups and covalent and hydrogen bonds formed, thermal stability, phase structure, and morphology were characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. The results show that the components in the hydrogels have good compatibility and formed honeycomb-like structures. In vitro studies confirmed that the hydrogels have good biodegradability at pH 7.4. Based on these properties, a CS/PVP hydrogel of the ratio of 60 : 40 crosslinked with 600 μL glutaraldehyde was selected for the in-situ loading of 200 mg of the drug metronidazole (MTZ). The hydrogel was characterized for cumulative drug release in the simulated physiological fluids and drug release kinetics using different models and for its antibacterial activity. The best-fit Korsmeyer–Peppas model suggests that MTZ release followed diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This hydrogel displays enhanced antimicrobial activity against Staphylococcus aureus, and Escherichia coli showed substantial inhibition zones indicating the produced CS/PVP hydrogels are promising candidates for controlled drug release applications.

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“…To date, a variety of drugs have been encapsulated into different electrospun fibers to endow the scaffolds with biofunctions, for example, anti-inflammatory, antibiotic, osteogenic induction, and anticancer ( Yoo et al, 2009 ; Zamani et al, 2010 ; Karthikeyan et al, 2012 ; Qiu et al, 2013 ; Jiang et al, 2014 ; Zhao et al, 2015 ; Yuan et al, 2016 ; Huang et al, 2019 ; Clitherow et al, 2020 ). In particular, many recent studies have suggested that the drug-loaded nanofibers possess synergistic therapeutic effect during the cure of oral diseases ( Wang et al, 2020 ; Rade et al, 2021 ). In one study, DEX was embedded in a hydrophobic central cavity of CD.…”

Section: Engineering Nanofibers With Biofunctionsmentioning

confidence: 99%

Engineering Electrospun Nanofibers for the Treatment of Oral Diseases

Wang¹,

Liu²,

Zhang³

et al. 2021

Front. Chem.

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With the increase of consumption of high-sugar foods, beverages, tobacco, and alcohol, the incidence rate of oral diseases has been increasing year by year. Statistics showed that the prevalence of oral diseases such as dental caries, dental pulpal disease, and periodontal disease has reached as high as 97% in 2015 in China. It is thus urgent to develop functional materials or products for the treatment of oral diseases. Electrospinning has been a widely used technology that is capable of utilizing polymer solution to generate micro/nano fibers under an appropriate high voltage condition. Owing to their excellent structures and biological performances, materials prepared by electrospinning technology have been used for a wide range of oral-related applications, such as tissue restoration, controlled drug release, anti-cancer, etc. In this regard, this article reviews the application and progress of electrospun nanofibers to various oral diseases in recent years. Firstly, engineering strategies of a variety of nanofiber structures together with their resultant functions will be introduced. Then, biological functions of electrospun nanofibers as well as their applications in the treatment of oral diseases are summarized and demonstrated. Finally, the development viewpoint of functional nanofibers is prospected, which is expected to lay the foundation and propose the direction for further clinical application.

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Physicochemical and in Vitro Antibacterial Evaluation of Metronidazole Loaded Eudragit S-100 Nanofibrous Mats for the Intestinal Drug Delivery

Cited by 29 publications

References 33 publications

Microfluidic Spinning of Metal–Organic Framework-Loaded Nanofibers toward High-Efficient Particulate Matter Removal and Antibacterial Filters

Microfluidic Spinning of Metal–Organic Framework-Loaded Nanofibers toward High-Efficient Particulate Matter Removal and Antibacterial Filters

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties

Engineering Electrospun Nanofibers for the Treatment of Oral Diseases

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