Physicochemical and nutraceutical properties of moringa ( Moringa oleifera ) leaves and their effects in an  in vivo  AOM/DSS-induced colorectal carcinogenesis model

Cuellar-Núñez, M. Liceth; Luzardo-Ocampo, Iván; Campos-Vega, Rocío; Gallegos‐Corona, Marco Alonso; Mejı́a, Elvira González de

doi:10.1016/j.foodres.2017.11.004

Cited by 85 publications

(43 citation statements)

References 56 publications

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“…Colonic pH and β-GA activity are other physiological parameters involved in colorectal carcinogenesis. The increase in the pH of the colon and the activity of the β-GA enzyme is related to the specific colon carcinogen DMH and its metabolite AOM, as well as in the presence of the DSS promoter [39,60,63,71]. Therefore, inhibition of β-GA in cecal, colonic, and fecal samples of both SOand AVA-treated groups is of major relevance, since β-glucuronidase is an enzyme also present in the human colonic microbiota which has the ability to hydrolyze many glucuronide conjugates and, as a consequence, can release active carcinogenic metabolites into the intestinal lumen [60].…”

Section: Discussionmentioning

confidence: 99%

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice

Damazo-Lima

Rosas-Pérez

Reynoso‐Camacho

et al. 2020

Foods

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The consumption of fruits, vegetables, nuts, legumes, and whole grains has been associated with a lower risk of colorectal cancer (CRC) due to the content of natural compounds with antioxidant and anticancer activities. The oat (Avena sativa L.) is a unique source of avenanthramides (AVAs), among other compounds, with chemopreventive effects. In addition, oat germination has shown enhanced nutraceutical and phytochemical properties. Therefore, our objective was to evaluate the chemopreventive effect of the sprouted oat (SO) and its phenolic-AVA extract (AVA) in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model. Turquesa oat seeds were germinated (five days at 25 • C and 60% relative humidity) and, after 16 weeks of administration, animals in the SO-and AVA-treated groups had a significantly lower inflammation grade and tumor (38-50%) and adenocarcinoma (38-63%) incidence compared to those of the AOM+DSS group (80%). Although both treatments normalized colonic GST and NQO1 activities as well as erythrocyte GSH levels, and significantly reduced cecal and colonic β-GA, thus indicating an improvement in the intestinal parameters, the inflammatory states, and the redox states of the animals, SO exerted a superior chemopreventive effect, probably due to the synergistic effects of multiple compounds. Our results indicate that oats retain their biological properties even after the germination process.

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Section: Discussionmentioning

confidence: 99%

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice

Damazo-Lima

Rosas-Pérez

Reynoso‐Camacho

et al. 2020

Foods

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“…Quercetin, kaempferol, and chlorogenic acid, are the main phenolic compounds found in moringa's methanol or water extracts (Vongsak et al, ). The plant has quercetin and kaempferol flavonoids, which decrease oxidative stress, and have antiproliferative, anti‐inflammatory, and antihypertensive properties (Coppin et al, ; Cuellar‐Nuñez et al, ; Tiloke, Phulukdaree, & Chuturgoon, ). Antiproliferative effect of its methanol extract on HCT‐116 human colorectal carcinoma cells showed a cytotoxic effect due to components of such as astragalin and isoquercetin (Tragulpakseerojn et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Its leaf extracts have anti-hypertensive, anti-inflammatory, and anti-ulcer effects (Pal, Mukherjee, & Saham, 1995). The extracts possess cytotoxic properties, chemopreventive traits, antiradical activity against free radicals, prevent oxidative damage to major biomolecules and protect against oxidative damage (Charoensin, 2014;Cuellar-Nuñez et al, 2018). The leaves have high contents of flavonoids glucosinolates, isothiocyanates, and phenolic acids (Brunelli et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant traits and protective impact ofMoringa oleiferaleaf extract against diclofenac sodium-induced liver toxicity in rats

El-Hadary

Ramadan

2018

J Food Biochem

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Moringa oleifera gained importance as a medicinal plant. The current study assesses Moringa leaf ethanol extracts (MLE) against experimentally diclofenac sodium (DcNa)‐induced liver toxicity in male rats. Leaves were extracted with different solvents differing in polarity. Assessment involved total phenolic compounds, total flavonoids and radical scavenging activity against 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH·). HPLC was performed for identifying phenolic compounds, wherein ethyl vanillin (1,205 mg/kg), 3‐OH‐tyrosol (812.2 mg/kg), benzoic acid (273.8 mg/kg), salicylic acid (240.0 mg/kg), chlorogenic acid (233.3 mg/kg) and 3,4,5‐methoxy‐cinnamic acid (172.5 mg/kg) were measured. Fifty animals (each treatment group consisted of 10 rats) were subjected to five treatments and the experiment lasted for 4 weeks. Animals were exposed to DcNa (100 mg/kg) and two doses of MLE as well as silymarin (an antioxidant flavonoid C25H22O10) for 4 weeks. Liver marker enzymes, including alkaline phosphatase, alanine transaminase, and aspartate transaminase as well as urea, uric acid, and creatinine were increased. Serum albumin and total protein decreased in DcNa‐treated rats. Homogenates nitric oxide increased in liver tissue of the DcNa‐treated rats, while the activity of each of glutathione peroxidase, glutathione‐S‐transferase, glutathione, and catalase decreased. It could be concluded that MLE in both doses and silymarin are considerably hepatoprotective with antioxidant activity (AOA) against DcNa‐induced hepatotoxicity in rats. Practical applications Administration of MLE caused improvements in kidney functions and acted as antioxidant enzymes as compared with silymarin (as a reference drug). AOA was exhibited by MLE in vivo, and this would have a positive effect against oxidative liver damage caused by DcNa. Plasma membrane was protected and the regenerative and reparative capacity of liver increased by phenolics in the MLE. The study demonstrated the MLE hepatoprotective activity and recommends using M. oleifera leaves for the treatment of liver disorders.

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“…Hot water or methanolic extracts are reported to have high chlorogenic acid, quercetin, and kaempferol content (Cuellar-Nuñez et al, 2018).…”

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confidence: 99%

Evaluating the Efficacy of Edible Coatings Incorporated with Moringa Leaf Extract on Postharvest of ‘Maluma’ Avocado Fruit Quality and Its Biofungicidal Effect

Kubheka¹,

Tesfay²,

Mditshwa³

et al. 2020

horts

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This study investigated the efficacy of edible gum arabic (GA) and carboxymethyl cellulose (CMC) containing moringa (M) leaf extract as postharvest treatments for maintaining organoleptic quality and controlling Colletotrichum gloeosporioides on ‘Maluma’ avocado fruit. For the quality study, after the fruit was dipped into the treatments: GA 10%, GA 15%, GA 10% + M, GA 15% + M, and CMC 1% + M and uncoated fruit served as control, the fruit were then stored at 5.5 °C [95% relative humidity (RH)] for 21 days, and moved to ambient conditions at 21 ± 1 °C (60% RH) for 7 days to simulate retail condition. Quality parameters that were evaluated include mass loss, firmness, and color changes (L*, a*, b*, respectively), and sensory quality attributes, such as taste, color, mouthfeel, odor, and overall acceptability. Fruit quality study results showed fruit coated with GA 15% + M and CMC 1% + M had lower mass loss (3.66%), retained firmness (62.37 N), and color changes [L* (30.85), a* (−2.33) and b* (7.14)] compared with other treatments. In this biofungicidal study on antimicrobial properties of extracts, treatments against fungi strains using an in vitro test were investigated, which showed treatments of moringa leaf extract, GA 10% + M, and GA 15% + M suppressed radial mycelial growth of C. gloeosporioides by 30%, 28%, and 33%, respectively. In conclusion, our study demonstrated that GA 15% + M and CMC 1% + M retained fruit firmness and lowered weight loss and suppressed mycelial growth of C. gloeosporioides on ‘Maluma’ avocado fruit. These edible coatings could therefore be an alternative organic postharvest coating treatment and could potentially be commercialized as a new organic biofungicide for the avocado fruit industry.

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Physicochemical and nutraceutical properties of moringa ( Moringa oleifera ) leaves and their effects in an in vivo AOM/DSS-induced colorectal carcinogenesis model

Cited by 85 publications

References 56 publications

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice

Antioxidant traits and protective impact ofMoringa oleiferaleaf extract against diclofenac sodium-induced liver toxicity in rats

Evaluating the Efficacy of Edible Coatings Incorporated with Moringa Leaf Extract on Postharvest of ‘Maluma’ Avocado Fruit Quality and Its Biofungicidal Effect

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