2015
DOI: 10.1111/jvim.13590
|View full text |Cite
|
Sign up to set email alerts
|

Physicochemical Approach to Determine the Mechanism for Acid–Base Disorders in 793 Hospitalized Foals

Abstract: BackgroundThe quantitative effect of strong electrolytes, unmeasured strong anions (UAs), pCO 2, and plasma protein concentrations in determining plasma pH can be demonstrated using the physicochemical approach. Plasma anion gap (AG) and strong ion gap (SIG) are used to assess UAs in different species.HypothesesStrong ions are a major factor influencing changes in plasma pH of hospitalized foals. AG and SIG accurately predict severe hyper‐l‐lactatemia ([l‐lac−] > 7 mmol/L).AnimalsSeven hundred and ninety three… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
7
0

Year Published

2015
2015
2024
2024

Publication Types

Select...
4
1
1

Relationship

0
6

Authors

Journals

citations
Cited by 10 publications
(7 citation statements)
references
References 45 publications
0
7
0
Order By: Relevance
“…This study showed that variability in the sSID calculations can affect either the diagnosis of acid-base disorders of sick horses or the evaluation of their disease state. 23 For example, using WBGA, 85% of the horses were diagnosed with a SID 4 acidosis and 15% had a normal SID 4 , whereas using PBMA, 44% and 55% of the horses were diagnosed with a SID 4 acidosis and normal SID 4 , respectively. These differences in the diagnosis of acid-base disorders could have diagnostic and therapeutic implications when a disorder is detected by 1 analyzer but not the other.…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…This study showed that variability in the sSID calculations can affect either the diagnosis of acid-base disorders of sick horses or the evaluation of their disease state. 23 For example, using WBGA, 85% of the horses were diagnosed with a SID 4 acidosis and 15% had a normal SID 4 , whereas using PBMA, 44% and 55% of the horses were diagnosed with a SID 4 acidosis and normal SID 4 , respectively. These differences in the diagnosis of acid-base disorders could have diagnostic and therapeutic implications when a disorder is detected by 1 analyzer but not the other.…”
Section: Discussionmentioning
confidence: 98%
“…Diagnostic assessment could be affected in a horse with USI that were higher than initially suspected, as was the condition of almost 50% of horses. For example, an increase in USI could prompt the clinicians to further investigate the source of those USI, such as determining phosphates, citrate, D-lactate, Krebs cycle intermediates, uremic acids and ketone bodies, 1,3,23,30 or assessing hepatic 31,32 and renal function. 31,33 Similarly, the USI variability between analyzers can also have prognostic implications.…”
Section: Discussionmentioning
confidence: 99%
“…Similar results were reported in sick calves 9,10 and foals. 5 In calves, with or without diarrhea, sSID contributed to 85% to 93% of the change in blood pH and 98% of the change in HCO 3 − , whereas in foals, sSID variables explained 83% to 94% of the changes in blood pH.…”
Section: Ssid Variables and Blood Ph And Hco 3 −mentioning
confidence: 92%
“…The few published studies focused on analysis of acid-base disorders in goats with pregnancy toxemia 1,2 and urolithiasis 3 using the traditional Henderson-Hasselbach (H-H) approach. 4 In recent decades, different studies in sick horses, [5][6][7][8] and cattle [9][10][11] have demonstrated the quantitative contribution of strong ions, plasma proteins, and PCO 2 to the changes in plasma H + activity and HCO 3 − concentration by using the simplified strong ion difference (sSID) approach. [12][13][14] The sSID proposes that 3 independent variables modify the plasma H + activity.…”
Section: Introductionmentioning
confidence: 99%
“…Initially, an attempt was made to solve this problem by adapting BE (base excess) to the quantitative method (Fencl‐Stewart equation) in order to quantify the metabolic component and Constable simplified the approach reducing calculation of SID to only the main ions (sodium [Na + ], potassium [K + ], chloride [Cl ‐ ] and L‐lactate) and assumed a small difference between real and measured SID (SID m ) that could be quantified by the strong ion gap (SIG) . Normal ranges of parameters used for quantitative acid‐base calculations and interpretation including values of strong ion difference (SID m ) and total nonvolatile weak buffers (A tot ) and the quantitative method has been applied in ill neonatal foals .…”
Section: Introductionmentioning
confidence: 99%