Physicochemical aspects involved in methotrexate release kinetics from biodegradable spray-dried chitosan microparticles

Mesquita, Philippe C.; Oliveira, Anderson Rodrigues de; Fernandes-Pedrosa, Matheus de Freitas; Oliveira, Anselmo Gomes de; Silva-Júnior, Arnóbio Antônio da

doi:10.1016/j.jpcs.2015.01.014

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…For the drug-loaded chitosan microparticles, the propranolol was dissolved with the copolymer at mass ratio drug-chitosan of 1:2. The drying conditions were previously established in previous studies [ 28 ]. The inlet temperature of 140 °C, outlet temperature of about 90 °C, air pressure of 0.1 MPa, air flow of 0.32 m 3 /min and a feed flow rate of 5 mL/min through a nozzle of 0.4 mm were used during the experiments.…”

Section: Methodsmentioning

confidence: 99%

Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide Chitosan Based Powders

et al. 2017

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Chitosan is a natural copolymer generally available in pharmaceutical and food powders associated with drugs, vitamins, and nutraceuticals. This study focused on monitoring the effect of the morphology and structural features of the chitosan particles for controlling the release profile of the active pharmaceutical ingredient (API) propranolol hydrochloride. Chitosan with distinct molecular mass (low and medium) were used in the formulations as crystalline and irregular particles from commercial raw material, or as spherical, uniform, and amorphous spray-dried particles. The API–copolymer interactions were assessed when adding the drug before (drug-loaded particles) or after the spray drying (only mixed with blank particles). The formulations were further compared with physical mixtures of the API with chitin and microcrystalline cellulose. The scanning electron microscopy (SEM) images, surface area, particle size measurements, X-ray diffraction (XRD) analysis and drug loading have supported the drug release behavior. The statistical analysis of experimental data demonstrated that it was possible to control the drug release behavior (immediate or slow drug release) from chitosan powders using different types of particles.

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Section: Methodsmentioning

confidence: 99%

Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide Chitosan Based Powders

et al. 2017

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“…The rate constant of the Higuchi equation has a structural similarity with the composite Fickian diffusivity (Flores & Kong, 2017). Release kinetics of many drugs, flavonoids, and organic acids has been modeled using this equation (Argin, Kofinas, & Lo, 2014; Bae et al., 2015; Mesquita, Oliveira, Pedrosa, de Oliveira, & da Silva, 2015; Palma, Garcia, Marquez‐Ruiz, Vergara, & Robert, 2014; Peng et al., 2010; Robert, García, Reyes, Chávez, & Santos, 2012). In the case of food systems, for the two‐step simulated digestion process, the release of bioactive agents in intestinal conditions could be modeled using the Higuchi model (Khan et al., 2010).…”

Section: Empirical and Semiempirical Release Modelsmentioning

confidence: 99%

Modeling the release of food bioactive ingredients from carriers/nanocarriers by the empirical, semiempirical, and mechanistic models

Malekjani

Jafari

2020

Comp Rev Food Sci Food Safe

138

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The encapsulation process has been utilized in the field of food technology to enhance the technofunctional properties of food products and the delivery of nutraceutical ingredients via food into the human body. The latter application is very similar to drug delivery systems. The inherent sophisticated nature of release mechanisms requires the utilization of mathematical equations and statistics to predict the release behavior during the time. The science of mathematical modeling of controlled release has gained a tremendous advancement in drug delivery in recent years. Many of these modeling methods could be transferred to food. In order to develop and design enhanced food controlled/targeted bioactive release systems, understanding of the underlying physiological and chemical processes, mechanisms, and principles of release and applying the knowledge gained in the pharmaceutical field to food products is a big challenge. Ideally, by using an appropriate mathematical model, the formulation parameters could be predicted to achieve a specific release behavior. So, designing new products could be optimized. Many papers are dealing with encapsulation approaches and evaluation of the impact of process and the utilized system on release characteristics of encapsulated food bioactives, but still, there is no deep insight into the mathematical release modeling of encapsulated food materials. In this study, information gained from the pharmaceutical field is collected and discussed to investigate the probable application in the food industry.

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“…As observed, free MTX occurred in a crystalline state, which was attributed to the well-dened diffraction peaks at 2q of 7.6 and 9.2, characteristic of its trihydrate form. 58,59 It was well-known that the width of X-ray diffraction peak was related to the size of crystallite and the broadened peak usually results from imperfect crystal. Hence, the broad peak of PAH indicated a amorphous phase.…”

Section: Ftir Uv-vis and Xrd Analysis Of Pah-mtx Nanoassembliesmentioning

confidence: 99%

Novel morphologies of poly(allyamine hydrochloride)–methotrexate nanoassemblies for methotrexate delivery

Wang

Zhao

et al. 2018

RSC Adv.

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Physicochemical aspects involved in methotrexate release kinetics from biodegradable spray-dried chitosan microparticles

Cited by 20 publications

References 33 publications

Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide Chitosan Based Powders

Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide Chitosan Based Powders

Modeling the release of food bioactive ingredients from carriers/nanocarriers by the empirical, semiempirical, and mechanistic models

Novel morphologies of poly(allyamine hydrochloride)–methotrexate nanoassemblies for methotrexate delivery

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