2009
DOI: 10.1208/s12249-009-9193-6
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Physicochemical Characteristics, Cytotoxicity, and Antioxidant Activity of Three Lipid Nanoparticulate Formulations of Alpha-lipoic Acid

Abstract: Abstract. Exogenously supplied alpha-lipoic acid (LA) has proven to be effective as an antioxidant. In an effort to develop a water-soluble formulation for topical administration, LA was formulated in the form of solid lipid nanoparticles (SLN), nanostructure lipid carriers (NLC), and nanoemulsion (NE) and characterized in terms of physical and biological properties. Mean particle size of 113, 110, and 121 nm were obtained for NE, NLC, and SLN, respectively, with narrow size distribution. Zeta potential was ap… Show more

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Cited by 87 publications
(54 citation statements)
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“…NLCs can be produced by several methods, most of which are adopted from polymeric nanoparticle preparations. These methods include high-pressure homogenization (Stecova et al, 2007;Huang et al, 2008;Ruktanonchai et al, 2009); microemulsion (Doktorovova et al, 2010;Souza et al, 2011); phase inversion (Souto et al, 2007); emulsification by sonication (Das and Chaudhury, 2011); emulsification-solvent-evaporation (ESE) (Lin et al, 2010); solvent diffusion and solvent injection/solvent displacement (Schubert and MullerGoymann, 2003); and the membrane contactor method (Charcosset et al, 2005). However, the most preferred method of NLC preparation is high-pressure homogenization (Iqbal et al, 2012).…”
Section: B Nanostructured Lipid Carriersmentioning
confidence: 99%
“…NLCs can be produced by several methods, most of which are adopted from polymeric nanoparticle preparations. These methods include high-pressure homogenization (Stecova et al, 2007;Huang et al, 2008;Ruktanonchai et al, 2009); microemulsion (Doktorovova et al, 2010;Souza et al, 2011); phase inversion (Souto et al, 2007); emulsification by sonication (Das and Chaudhury, 2011); emulsification-solvent-evaporation (ESE) (Lin et al, 2010); solvent diffusion and solvent injection/solvent displacement (Schubert and MullerGoymann, 2003); and the membrane contactor method (Charcosset et al, 2005). However, the most preferred method of NLC preparation is high-pressure homogenization (Iqbal et al, 2012).…”
Section: B Nanostructured Lipid Carriersmentioning
confidence: 99%
“…29 The stability of chemical labile hydrophobic antioxidants like retinol, Coenzyme Q10, alpha-lipoic acid, beta-carotene, and alpha-tocopherol could be enhanced when incorporating them into lipid nanoparticles. [30][31][32] Thus, the encapsulation of RSV into a lipid nanosystem might also be helpful in improving stability, whilst performing a protective effect as sufficiently as the RSV molecule itself.…”
Section: Preparation Of Rsv-loaded Slns and Nlcsmentioning
confidence: 99%
“…To adequately utilize ALA, shortcomings associated with its sparingly solubility, photodegradation (Matsugo et al, 2011), lability and objectionable sulfur smell of ALA have to be operated before it could be used as an alternative physiologically functional active substance (Kofuji et al, 2009;Ruktanonchai et al, 2009;Moyano & Segall, 2011). Furthermore, the degradation of ALA is associated with a sulfide-smell and an irritating odour in consequence of the sulphur it contains (Kofuji et al, 2008(Kofuji et al, , 2009Takahashi et al, 2011).…”
Section: Introductionmentioning
confidence: 99%