Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole With Chitosan

Grimling, Bożena; Jasińska, Justyna; Meler, Jan; Szcześniak, Maria; Pluta, Janusz; Gòrniak, Agata

doi:10.15259/pcacd.21.06

Cited by 2 publications

(2 citation statements)

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“…In the range 900–1200 cm −1 were shown the bands of peaks for the following bonds: 1150 cm −1 (asymmetric stretching of C-O-C bridge), 1059 cm −1 (C-O stretch, secondary hydroxyl group), and 1026 cm −1 (C-O stretch, primary hydroxyl group). The peak at 1150 cm −1 was characteristic of glycoside linkages [ 60 , 61 , 62 , 63 ]. These results illustrated that no change occurred in the chemical structure of the S. baicalensis radix extract after being mixed with chitosan.…”

Section: Resultsmentioning

confidence: 99%

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Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Chanaj-Kaczmarek

Osmałek

Szymańska

et al. 2021

IJMS

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Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.

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Section: Resultsmentioning

confidence: 99%

“…Surprisingly, after mixing the lyophilized extract with chitosans, a slight increase in the dissolution rate of wogonin was observed ( Figure 3 c). The previously published studies indicated that chitosan is a proper carrier for poorly water-soluble drugs [ 61 , 64 ].…”

Section: Resultsmentioning

confidence: 99%