Physicochemical characterization of Persian fresh royal jelly samples

Hamledari, Azam; Hasibi, Forough; Hajibabaei, Khadijeh

doi:10.1080/00218839.2023.2237726

Journal of Apicultural Research

2023

DOI: 10.1080/00218839.2023.2237726

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Physicochemical characterization of Persian fresh royal jelly samples

Azam Hamledari

Forough Hasibi

Khadijeh Hajibabaei

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2024

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Inhibitory Effects of Royal Jelly and Its Functional Components on the Proliferation of MKN-28 Gastric Cancer Cells

Ma,

Wang,

et al. 2024

J. Agric. Food Chem.

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Royal jelly (RJ) is a natural food product with nutritional value and anticancer activity. However, their effects on gastric cancer are unclear. Here, we show that treatment with 5–320 μg/mL of RJ, ethanol extract (RJEE), and protein hydrolyzate (RJPH) decreased the viability of MKN-28 gastric cancer cells, with a half-maximal inhibitory concentration of 123.22 μg/mL for RJEE. RJ, RJEE, and RJPH increase the lactate dehydrogenase release rate and change the morphology of the cells, resulting in cell shrinkage, nucleoplasm condensation, and the formation of apoptotic bodies. RJ and its functional components stagnated the cell cycle in the G0/G1 phase, accompanied by the accumulation of reactive oxygen species, decreased mitochondrial membrane potential, and increased expression levels of p53 and p21 proteins, caspase-3 activation, and apoptosis. Therefore, RJ, RJEE, and RJPH have potential inhibitory effects on the proliferation of gastric cancer cells.

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Inhibitory Effects of Royal Jelly and Its Functional Components on the Proliferation of MKN-28 Gastric Cancer Cells

Ma,

Wang,

et al. 2024

J. Agric. Food Chem.

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show abstract

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Physicochemical characterization of Persian fresh royal jelly samples

Cited by 1 publication

References 24 publications

Inhibitory Effects of Royal Jelly and Its Functional Components on the Proliferation of MKN-28 Gastric Cancer Cells

Inhibitory Effects of Royal Jelly and Its Functional Components on the Proliferation of MKN-28 Gastric Cancer Cells

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