Physicochemical characterization, phytochemical analysis, and pharmacological evaluation of Sambucus wightiana

Chashoo, Ishtiaq Ahmad; Wani, Shahid Ud Din; Raja, Waseem; Bhat, Zulfiqar Ali; Ali, M. Ayub; Alshehri, Sultan; Alam, Prawez; Ghoneim, Mohammed M.; Asdaq, Syed Mohammed Basheeruddin; Shakeel, Faiyaz

doi:10.1016/j.arabjc.2023.105170

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…The IR spectra (KBr pellets) between 400 and 4000 cm -1 were recorded using a total of 10 images [ 35 ]. We recorded the FTIR spectra to search for potential functional groups [ 36 – 38 ].…”

Section: Methodsmentioning

confidence: 99%

In-vitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities

Bhat,

Zargar,

Wani

et al. 2024

J Pharm Health Care Sci

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Background Multidrug-resistant bacterial strains cause several serious infections that can be fatal, such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae (often referred to as ESKAPE pathogens). Since ancient times, several indigenous medical systems in India have utilized diverse medicinal plants (approximately 80,000 species) as conventional treatments for a variety of illnesses. A member of the Fabaceae family, also referred to as “Himalayan indigo,” Indigofera heterantha Wall, is well known for its therapeutic properties. Methods The present study investigated the antibacterial, antifungal and antihelmintic properties of the roots, bark, leaves, and flowers of I. heterantha from the Kashmir Himalayas. The effectiveness of the extracts against bacteria, fungi, and earthworms. Three of the tested organisms for bacteria were ESKAPE pathogens, as they are responsible for creating fatal bacterial infections. The antifungal potency of I. heterantha aqueous and methanolic extracts was evaluated using the Agar Well Diffusion Assay. The antihelmintic activity was carried out on an adult Pheretima posthuma Indian earth worm, which shares physiological and anatomical similarities with human intestinal roundworm parasites. Results The methanolic extracts of root and bark have shown prominent activity against all bacterial strains, whereas aqueous extracts of flower, root, and leaves have shown promising activity against Staphylococcus aureus. The aqueous extract demonstrated good activity against S. cerevisiae at a concentration of 200 mg/ml with a zone of inhibition of 16 mm, while the methanolic extract displayed comparable activity against the fungal strains. The remaining two strains, P. crysogenum and A. fumigatus, were only moderately active in response to the extracts. All the extracts have shown anthelmintic activity except aqueous flower. Conclusion These results will pave the way for the bioassay-guided isolation of bioactive constituents that may act as hits for further development as potential antibacterial agents against drug-resistant microbial and helminthic infections.

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Section: Methodsmentioning

confidence: 99%

In-vitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities

Bhat,

Zargar,

Wani

et al. 2024

J Pharm Health Care Sci

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Antidiabetic and antioxidant activities of the hydroalcoholic extracts of Canthium coromandelicum (Burm.f.) Alston leaf in Streptozotocin-induced diabetic rats

Amalraj,

Krupa,

Raj

et al. 2024

Process Biochemistry

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Physico-Phytochemical, Heavy metal and Microbiological Analysis of Hygrophila auriculata (schumach.) Heine. Leaves and seeds

H. Jadav,

S. Shah

2024

RJPT

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Hygrophila Auriculata is a plant with several medicinal properties that are highly valued around the world. It is used to prevent and treat numerous diseases. The study aimed to analyze the physicochemical, qualitative and quantitative phytochemical, heavy metal content by ICP-MS, and microbiological content of the leaves and seeds of the Hygrophila auriculata (schumach.) Heine. The aim was to develop simple and reliable criteria to help ensure the quality of this crude drug. Additionally, TLC was implemented to determine the proximity of terpenoids and phytosterol in the plant. The plant contains various phyto nutrients that suggest its pharmaceutical significance.

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Physicochemical characterization, phytochemical analysis, and pharmacological evaluation of Sambucus wightiana

Cited by 3 publications

References 44 publications

In-vitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities

In-vitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities

Antidiabetic and antioxidant activities of the hydroalcoholic extracts of Canthium coromandelicum (Burm.f.) Alston leaf in Streptozotocin-induced diabetic rats

Physico-Phytochemical, Heavy metal and Microbiological Analysis of Hygrophila auriculata (schumach.) Heine. Leaves and seeds

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