Physicochemical characterization, water sorption and solubility of adhesive systems incorporated with titanium tetrafluoride, and its influence on dentin permeability

Cardoso, Ruthinea Faria de Moraes; Basting, Rosanna Tarkany; França, Fabiana Mantovani Gomes; Amaral, Flávia Lucisano Botelho do; Basting, Roberta Tarkany

doi:10.1016/j.jmbbm.2021.104453

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Although the interaction force between MPS and dentin is weak, in this study, the zeta potential of collagen silanized at different concentrations of MPS was significantly reduced compared with that of pure collagen to −23 mV. Zeta potential is one of the factors determining particle non-aggregation . Collagen powders appear more stable regardless of the concentration of silane.…”

Section: Discussionmentioning

confidence: 57%

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Role of 3-Methacryloxypropyltrimethoxysilane in Dentin Bonding

et al. 2022

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In this study, we aimed to examine the effect of 3-methacryloxypropyltrimethoxysilane (MPS) on dentin collagen and the impact of MPS and 10-methacryloyloxydecyl dihydrogen phosphate (MDP) together and separately on resin–dentin bonding. Eight groups of primers were prepared: control group, MDP, MPS5, MPS5 + MDP, MPS10, MPS10 + MDP, MPS15, and MPS15 + MDP. The potential interaction between MPS and collagen was assessed by molecular dynamics, contact angle measurement, zeta potential measurement, and chemoanalytic characterization using X-ray photoelectron spectroscopy, Raman spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and ultraviolet–visible spectroscopy. Microtensile bond strength (μTBS) and nanoleakage were evaluated after 24 h or 12 months of water storage. In situ zymography was used to evaluate the enzyme activity at the bonded interface. According to chemoanalytic characterization and molecular dynamics, a weak interaction between MPS and collagen was observed. MPS enhanced the hydrophobicity and negative charge of the collagen surface ( P < 0.05). Applying an MDP-containing primer increased μTBS ( P > 0.05) and reduced fluorescence after 24 h of water storage. Water storage for 12 months decreased μTBS ( P < 0.05) and increased nanoleakage for all groups. MPS conditioning did not change μTBS and nanoleakage after 24 h of water storage or aging. The MPS10 + MDP and MPS15 + MDP groups presented more silver nitrate and μTBS decrease than the MDP group ( P < 0.05). These results indicated that MPS had a weak interaction with collagen that enhanced its surface negative charge and hydrophobicity without adversely affecting dentin bonding. However, compared to MDP alone, mixing MDP with MPS impaired their effectiveness and made the dentin bonding unstable.

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Section: Discussionmentioning

confidence: 57%

“…Zeta potential is one of the factors determining particle non-aggregation. 30 Collagen powders appear more stable regardless of the concentration of silane. At the same time, the surface of silanized dentin showed better hydrophobicity, which was also independent of silane concentration.…”

Section: Discussionmentioning

confidence: 93%

Role of 3-Methacryloxypropyltrimethoxysilane in Dentin Bonding

et al. 2022

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“…Importantly, the BSCB is reported to be more permeable than the BBB with relatively low expression of tight junction proteins [ 31 ]. Thus, cytokines can pass through the BSCB with more ease than the BBB [ 32 ]. However, in this study, the induction of pro-inflammatory cytokines in the spinal cord was synergistic with the brain.…”

Section: Discussionmentioning

confidence: 99%

Sepsis-associated neuroinflammation in the spinal cord

et al. 2022

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Septic patients commonly present with central nervous system (CNS) disorders including impaired consciousness and delirium. Today, the main mechanism regulating sepsis-induced cerebral disorders is believed to be neuroinflammation. However, it is unknown how another component of the CNS, the spinal cord, is influenced during sepsis. In the present study, we intraperitoneally injected mice with lipopolysaccharide (LPS) to investigate molecular and immunohistochemical changes in the spinal cord of a sepsis model. After LPS administration in the spinal cord, pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha mRNA were rapidly and drastically induced. Twenty-four-hour after the LPS injection, severe neuronal ischemic damage spread into gray matter, especially around the anterior horns, and the anterior column had global edematous changes. Immunostaining analyses showed that spinal microglia were significantly activated and increased, but astrocytes did not show significant change. The current results indicate that sepsis induces acute neuroinflammation, including microglial activation and pro-inflammatory cytokine upregulation in the spinal cord, causing drastic neuronal ischemia and white matter edema in the spinal cord.

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