Physicochemical characterizations and release studies of nicotine–magnesium aluminum silicate complexes

Pongjanyakul, Thaned; Khunawattanakul, Wanwisa; Puttipipatkhachorn, Satit

doi:10.1016/j.clay.2009.03.004

Cited by 48 publications

(29 citation statements)

References 24 publications

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“…4d). These results suggest that the amine group of the pyridine ring could interact with MAS via electrostatic forces and intermolecular hydrogen bonding (9). FTIR spectra of the pH 9 NCT-MAS complex-loaded SA tablets showed a shift of the SA COO − stretching peaks (Fig.…”

Section: Molecular Interaction Of Sa With Masmentioning

confidence: 86%

“…The negatively charged surfaces of the silicate layers strongly interact with NCT at different pH levels (8), leading to the formation of NCT-MAS complexes. This allows NCT to intercalate into the silicate layers of MAS that was investigated using a powder X-ray diffractometry in the previous study (9). The NCT-MAS complex particles enhance NCT's thermal stability and were shown to sustain NCT release in distilled water and phosphate buffer with a pH 6 (9).…”

Section: Introductionmentioning

confidence: 99%

“…This allows NCT to intercalate into the silicate layers of MAS that was investigated using a powder X-ray diffractometry in the previous study (9). The NCT-MAS complex particles enhance NCT's thermal stability and were shown to sustain NCT release in distilled water and phosphate buffer with a pH 6 (9). Additionally, MAS forms a microcomposite material with sodium alginate (SA), a negatively charged polysaccharide, via intermolecular hydrogen bonding (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Nicotine–Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery

Kanjanabat

2011

AAPS PharmSciTech

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Abstract. Nicotine (NCT) buccal tablets consisting of sodium alginate (SA) and nicotine-magnesium aluminum silicate (NCT-MAS) complexes acting as drug carriers were prepared using the direct compression method. The effects of the preparation pH levels of the NCT-MAS complexes and the complex/SA ratios on NCT release, permeation across mucosa, and mucoadhesive properties of the tablets were investigated. The NCT-MAS complex-loaded SA tablets had good physical properties and zero-order release kinetics of NCT, which indicate a swelling/erosion-controlled release mechanism. Measurement of unidirectional NCT release and permeation across porcine esophageal mucosa using a modified USP dissolution apparatus 2 showed that NCT delivery was controlled by the swollen gel matrix of the tablets. This matrix, which controlled drug diffusion, resulted from the molecular interactions of SA and MAS. Tablets containing the NCT-MAS complexes prepared at pH 9 showed remarkably higher NCT permeation rates than those containing the complexes prepared at acidic and neutral pH levels. Larger amounts of SA in the tablets decreased NCT release and permeation rates. Additionally, the presence of SA could enhance the mucoadhesive properties of the tablets. These findings suggest that SA plays the important role not only in controlling release and permeation of NCT but also for enhancing the mucoadhesive properties of the NCT-MAS complex-loaded SA tablets, and these tablets demonstrate a promising buccal delivery system for NCT.KEY WORDS: buccal tablets; magnesium aluminum silicate; nicotine; release and permeation; sodium alginate.

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Section: Molecular Interaction Of Sa With Masmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Nicotine–Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery

Kanjanabat

2011

AAPS PharmSciTech

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“…Pongjanyakul [66] Коришћењем фосфатног пуфера pH 6 (Слика 13 (б)), време при коме се постиже 60% ослобођеног никотина из никотин-МАS комплекса је значајно веће у случају физичке смеше. Нема значајне разлике у брзини ослобађања никотина у фосфатни пуфер из комплекса.…”

Section: време (H) степен ослобађања (%)unclassified

“…Слика 13. Кинетичке криве ослобођања никотина из комплекса никотин-МАС, добијених из физичке смеше и припремљених при различитим pH вредностима у дејонизовану воду (a) и фосфатни пуфер pH 6 (б) [66] Ови резултати показују да се ослобађање никотина у фосфатни пуфер при pH 6 дешава процесом измене катјона, при чему се комплекси припремљени на pH 4 више измењују од оних припремљених на pH 7 и 10. У више радова [68][69][70][71] Никотин је растворљив у води и потпуно се меша са водом испод 333К и изнад 483 К у свим односима [73].…”

Section: време (H) степен ослобађања (%)unclassified

Isothermal kinetics of nicotine desorption and release from different adsorbents and hydrogel

Lazarević¹

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Clay-Based Composites and Nanocomposites for Drug Delivery

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et al. 2023

Advances in Material Research and Technology

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Physicochemical characterizations and release studies of nicotine–magnesium aluminum silicate complexes

Cited by 48 publications

References 24 publications

Preparation and Characterization of Nicotine–Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery

Preparation and Characterization of Nicotine–Magnesium Aluminum Silicate Complex-Loaded Sodium Alginate Matrix Tablets for Buccal Delivery

Isothermal kinetics of nicotine desorption and release from different adsorbents and hydrogel

Clay-Based Composites and Nanocomposites for Drug Delivery

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