Physicochemical Interactions in Nanofunctionalized Alginate/GelMA IPN Hydrogels

Abstract

Polymeric hydrogels are currently at the center of research due to their particular characteristics. They have tunable physical, chemical, and biological properties making them a material of choice for a large range of applications. Polymer-composite and nanocomposite hydrogels were developed to enhance the native hydrogel’s properties and to include numerous functionalities. In this work, alginate/gelatin-methacryloyl-based interpenetrating polymer network hydrogels were prepared with different alginate concentrations and investigated before and after the functionalization with nanoliposomes. The multiscale analysis was obtained through Fourier transform infrared spectroscopy and proton nuclear magnetic resonance. The results show interactions between two polymers as well as between the nanoliposomes and biopolymer.

Efficient TGF-β1 Delivery to Articular Chondrocytes In Vitro Using Agro-Based Liposomes

“…Ultimately, agro-based rapeseed liposomes were recently proposed as a new, safe and effective alternative for chondrocyte transfection [ 6 ]. Liposomes are mainly composed of amphiphilic phospholipids, and due to the similarities between their lipid bilayer and biological membranes, they are a promising delivery system, which can safely deliver and control the release of drugs and bioactive molecules [ 7 , 8 , 9 ]. Furthermore, bioactive agents are well protected once encapsulated in liposomes from the external harsh in vivo environment [ 10 , 11 , 12 ].…”

Nanoparticle-Reinforced Tough Hydrogel as a Versatile Platform for Pharmaceutical Drug Delivery: Preparation and in Vitro Characterization

“…Moreover, at neutral pH, the lateral functional groups of GelMA are charged. As a result, they can have strong physical interaction with the anisotropically charged nSi. , Figure A highlights the supramolecular interaction between GelMA and nSi. Here, nSi was added to the GelMA prepolymer before introducing the chemical cross-linking agents APS and TEMED.…”

Multichannel Multijunction Droplet Microfluidic Device to Synthesize Hydrogel Microcapsules with Different Core–Shell Structures and Adjustable Core Positions

“…59 Gelatin, undoubtedly, is an intriguing polymer owing to the existence of Arg-Gly-Asp (RGD), bioactive sequences that are useful for cell entrapment, and allow active molecular species to undergo binding with the polymeric network. 60,61 Nevertheless, GelMA-based hydrogels have rather poor mechanical characteristics (i.e., toughness and strength). 56 The weak mechanical qualities of GelMA can be compensated for by the shell of the core−shell structured microcapsules, which are made of polyacrylamide (PAM).…”

“…An "eggbox" is created as a result of this association, eventually generating a network. 61 Herein, we designed and prepared several multichannel and multijunctional droplet microfluidic devices based on soft lithography for the effective synthesis of core−shell hydrogel microcapsules for various applications. Meanwhile, two different cross-linking processes (UV exposure and interfacial polymerization) were utilized to synthesize different types of core−shell structured hydrogel microcapsules.…”

“…Gelatin methacryloyl (GelMA)-based hydrogels have excellent cell adhesion sites and are biocompatible when used as the cores of core–shell structured microcapsules. − By replacement of the amine group in gelatin with methacrylate anhydride, gelatin is modified into GelMA anhydride . Gelatin, undoubtedly, is an intriguing polymer owing to the existence of Arg-Gly-Asp (RGD), bioactive sequences that are useful for cell entrapment, and allow active molecular species to undergo binding with the polymeric network. , Nevertheless, GelMA-based hydrogels have rather poor mechanical characteristics (i.e., toughness and strength) …”