Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

Asasutjarit, Rathapon; Larpmahawong, Papassara; Fuongfuchat, Asira; Sareedenchai, Vipaporn; Veeranondha, Sukitaya

doi:10.1208/s12249-013-0057-8

Cited by 26 publications

(32 citation statements)

References 21 publications

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“…The part of the Mangosteen from where the drug is taken, is due to dried pericarp and its preparation. From the data of the studies, pharmacological properties are indeed attributed to the dry extract obtained from the standardized pericarp in active constituents (Pothitirat et al, ; Asasutjarit et al, ).…”

Section: Discussionmentioning

confidence: 99%

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

et al. 2016

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Several studies have shown that xanthones obtained from Garcinia Mangostana (GM) have remarkable biological activities. α-mangostin (α-MG) is the main constituent of the fruit hull of the GM. Several findings have suggested that SIRT-1, a nuclear histone deacetylase, could influence cellular function by the inhibition of NF-kB signaling. ROS can inhibit SIRT-1 activity by initiating oxidative modifications on its cysteine residues, and suppression of SIRT-1 enhances the NF-κB signaling resulting in inflammatory responses. The goals of the present study were to evaluate the quantity of α-MG in the methanolic extract of GM (Vithagroup Spa) and to investigate the activity of this xanthone in U937 cell line and in human monocytes from responsive to inflammatory insult analyzing the possible changes on the activation of SIRT-1 protein via NF-Kb. Cells were treated with the methanolic extract of GM and/or LPS. The chromatographic separation of α-MG was performed by an HPLC analysis. EX 527, a specific SIRT-1 inhibitor, was used to determine if SIRT-1/NfkB signaling pathway might be involved in α-MG action on cells. Our results show that α-MG inhibits p65 acetylation and down-regulates the pro-inflammatory gene products as COX-2, iNOS via SIRT-1 activation. Cells treated with EX 527 showed an up-regulation of NFkB acetylation and an over expression of inducible enzymes and their product of catalysis (NO and PGE2). These results suggest that α-MG may be useful for the development of alternative pharmacological strategies aimed at reducing the inflammatory process. J. Cell. Physiol. 231: 2439-2451, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

et al. 2016

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“…While hardness is defined as the maximum force during a movement of a disc into a gel, adhesiveness is the ability of an FFS to adhere on a disc which is determined by the force of a disc in the upward movement [137]. To evaluate the in vitro film-forming drying time, a small amount of FFS is put into an acrylic plate (or Petri dish, microscopic slide) and observed by naked eyes [44,59,138,139]. The observations of the degree of uniformity, cosmetic appearance (such as transparency), and peelability are also evaluated in some circumstances [6,59].…”

Section: Evaluation Of the Physico-chemical Properties Of Controllmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

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“…It is applied to the skin as a gel, but then can form a transparent, barely noticeable film in situ as the solvent evaporate and can be easily peeled off when desired. The advantages of FFG are ease of application, minimal skin irritation, prevention or treatment of secondary bacterial infections, enhanced drug release and reduced application frequency due to a longer duration of delivery [8,9] . However, most of FFGs contain high amount of ethanol that could lead to skin irritation [7] .…”

mentioning

confidence: 99%

Characterization and Evaluation of ?-Mangostin-loaded Film-forming Gels for Acne Treatment

Tanngoen¹,

Lamlertthon²,

Tiyaboonchai³

2020

ijps

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Tanngoen et al.: Evaluation of AM-FFGs Against Acne-causing bacteriaIn this study, α-mangostin, extracted from mangosteen peel, was developed in to a topical film-forming gel antiacne preparation using different film-forming polymers as carriers. The physicochemical properties and α-mangostin incorporation efficiency were evaluated. In vitro permeation of α-mangostin-loaded film-forming gels, antibacterial activity against Propionibacterium acnes and Staphylococcus aureus were examined. The optimal formulations were viscous gels, which could convert into a dry film within 30 min after application. The films were transparent, flexible and easy to peel off. Scanning electron micrographs of the α-mangostin-loaded film-forming gels revealed a rough surface with an interior porous structure while blank film-forming gels showed smooth and compact morphology. The high α-mangostin incorporation efficiency up to 96 % was achieved. In vitro permeation studies showed a biphasic permeation profile with a fast permeation characteristic within 30 min followed by a slow permeation up to 8 h. α-Mangostinloaded film-forming gels demonstrated efficient antibacterial activities against P. acnes and S. aureus. Moreover, α-mangostin-loaded film-forming gels showed good physicochemical stability during storage at 4º for 6 mo. In summary, the developed α-mangostin-loaded film-forming gels are good candidates for topical antiacne treatments.

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Physicochemical Properties and Anti-Propionibacterium acnes Activity of Film-Forming Solutions Containing Alpha-Mangostin-Rich Extract

Cited by 26 publications

References 21 publications

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Characterization and Evaluation of ?-Mangostin-loaded Film-forming Gels for Acne Treatment

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