Physicochemical properties and antidiabetic effects of a polysaccharide from corn silk in high-fat diet and streptozotocin-induced diabetic mice

Pan, Ying‐Ming; Wang, Cong; Chen, Zhongqin; Li, Weiwei; Yuan, Guoqi

doi:10.1016/j.carbpol.2017.01.092

Cited by 128 publications

(50 citation statements)

References 36 publications

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“…It has been also reported to be useful in gonorrhea, acute and chronic cystitis, and bladder irritation due to uric acid and phosphate gravel [11, 14, 37, 38, 42-44, 46, 47, 51, 54-59]. Recently, corn silk polysaccharides have been suggested to be a good choice as functional food or medicine for the treatment of type 2 diabetes mellitus due to its hypoglycemic activity [60].…”

Section: Ethanolmentioning

confidence: 99%

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Nawaz¹,

Muzaffar²,

Aslam³

et al. 2018

Corn - Production and Human Health in Changing Climate

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Corn seeds are used as a nutritional source for humans, and the stem and leaves are utilized as fodder for cattle throughout the world. Corn silk and corn cob are usually discarded as waste. This chapter highlights the nutritional as well as medicinal importance of various parts of corn plant. All parts of corn plant are good source of a variety of bioactive phytochemical compounds which possess antioxidant potential. The principal phytochemicals present in corn seed and corn silk include polyphenols, phenolic acids, flavonoids, anthocyanins, glycosides, carotenoids, and polysaccharides of biological importance, reducing compounds and some water-soluble vitamins. The presence of these phytochemicals makes corn a medicinal plant which shows various biological activities particularly the antioxidant, antimicrobial, antidiabetic, anti-obesity, antiproliferative, hepatoprotective, cardioprotective, and renal-protective activities. On the account of its high antioxidant potential, all parts of corn plant can be used for the management of oxidative stress and the treatment of various diseases.

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Section: Ethanolmentioning

confidence: 99%

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Nawaz¹,

Muzaffar²,

Aslam³

et al. 2018

Corn - Production and Human Health in Changing Climate

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show abstract

“…Recently, natural polysaccharides have attracted much attention in the field of biochemistry and pharmacology because of their health benefits such as immune regulation (Li et al, ; Surin, Surayot, Seesuriyachan, You, & Phimolsiripol, ), antitumor (Meng, Liang, & Luo, ; Zhao et al, ), antifatigue (Jia et al, ), antioxidation (Chaouch, Hafsa, Rihouey, Cerf, & Majdoub, ; Mao et al, ), antidiabetes (Liu, Sun, Rao, Su, Li, et al, ), antihyperglycemia, and antihyperlipidemia (Liu, Sun, Rao, Su, & Yang, ). Stigma maydis (corn silk), a by‐product from corn cultivation and processing (Žilić, Janković, Basić, Vančetović, & Maksimović, ), has been used worldwide as a traditional herbal medicine for the treatment of chronic diseases, such as diabetes (Pan et al, ), obesity (Lee et al, ), hypertension (George & Idu, ), and cystitis (Peng, Zhang, & Zhou, ), due to its multiple bioactive components including polysaccharides, flavonoids, steroids, alkaloids, saponins, proteins, volatile oils, tannins, and vitamins (Zhao et al, ). As one of the major ingredients in stigma maydis, stigma maydis polysaccharides account for many pharmacological activities with no toxicity (Zhao et al, ); however, its antihyperlipidemia effect is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Deng

Yang

Zhu

et al. 2019

Food Science & Nutrition

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This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP‐1. This polysaccharide was composed of D‐mannose, L‐rhamnose, D‐glucose, D‐galactose, L‐arabinose, D‐xylose, and D‐galacturonic acid, with a molar ratio of 1.00:0.21:1.41:1.44:0.70:0.44:0.56. The SMP‐1 was mainly bonded by (1 → 6) and (1 → 3) linkages, with various monosaccharides being evenly distributed in the main and side chains. Moreover, SMP‐1 had neither triple‐helical structure nor molecular aggregation. Importantly, the SMP‐1 could effectively bind the bile acids in vitro and significantly lower the total cholesterol, triglyceride, low‐density lipoprotein cholesterol levels, and moderately increase the high‐density lipoprotein cholesterol level in poloxamer 407‐induced hyperlipidemic mice. Moreover, pretreatment with SMP‐1 (≥300 mg/kg) could remarkably reduce fat accumulation and restore hepatocyte morphology in the liver of hyperlipidemic mice. Altogether, these findings indicated that SMP‐1 could be developed as a safe and effective food supplement for preventing and treating hyperlipidemic disorders.

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“…The composition of neutral monosaccharide was measured by gas chromatography (GC) after conversion into acetylated derivatives according to our previous studies (Pan et al ., ). Every sample was determined in triplicate.…”

Section: Methodsmentioning

confidence: 97%

Physicochemical characterisation and α‐amylase inhibitory activity of tea polysaccharides under simulated salivary, gastric and intestinal conditions

Wang

Yuan

et al. 2017

Int J of Food Sci Tech

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Summary Tea polysaccharides (TPS) are one of the main components of tea with various bioactivities. Digestion could result in the changes of the physicochemical properties and bioactivities of polysaccharides. The objective of this study was to determine the changes in physicochemical properties and α‐amylase inhibitory activities of TPS after simulated digestion. The structure of TPS determined by UV, IR and SEM showed that no obvious changes after salivary digestion, but significant changes after gastrointestinal digestion were observed. After intestinal digestion, the contents of reducing sugar were increased from 0.650 ± 0.011 to 1.594 ± 0.078 mm, and the centre molecular weight was decreased from 540.57 to 375.35 KDa. The molar ratio of monosaccharide was changed after digestion. And α‐amylase inhibition rate was significantly increased (P < 0.05). The results could provide information on the digestibility of TPSin vitro and contribute to the development of related functional foods or medicines.

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Physicochemical properties and antidiabetic effects of a polysaccharide from corn silk in high-fat diet and streptozotocin-induced diabetic mice

Cited by 128 publications

References 36 publications

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Physicochemical characterisation and α‐amylase inhibitory activity of tea polysaccharides under simulated salivary, gastric and intestinal conditions

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