Physicochemical properties and potential beneficial effects of porphyran from Porphyra haitanensis on intestinal epithelial cells

Qiu, Hua-Mai; Suresh, Veeraperumal; Lv, Jiehuan; Wu, Ting-Chu; Zhang, Zhipeng; Zeng, Qingkai; Liu, Yang; Chen, Xianqiang; Aweya, Jude Juventus; Cheong, Kit-Leong

doi:10.1016/j.carbpol.2020.116626

Cited by 42 publications

(26 citation statements)

References 37 publications

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“…1, FTIR was used to analyse the chemical bonds of PHPs in different origins and harvest periods. Some studies have reported that typical absorption peaks of PHPs at 3423, 1651, 1415, 1228, 1074, 933 and 813 cm −1 (Qiu et al ., 2020). The strong absorption peak at 3423 cm −1 was attributed to the stretching vibration of inter‐ and intramolecular bonds of hydroxyl groups (Gao et al ., 2017).…”

Section: Resultsmentioning

confidence: 99%

“…The absorption peak at 1155 cm −1 , 1074 cm −1 and 1039 cm −1 were the pyranose ring absorption, 1155 cm −1 was the asymmetric stretching vibration peak of glycosidic bond C—O in the internal ether ring C—O—C, 1074 cm −1 was the variable angle vibration absorption of O—H, and 1039 cm −1 was the C—OH + S═O (Khan et al ., 2020). The weak absorption peak at 933 cm −1 was the characteristic absorption of 3,6‐anhydrogalactose (Qiu et al ., 2020). The absorption of the β‐type glycosidic bond was around 893 cm −1 and 813 cm −1 indicated that it contained galactopyranose, which confirmed the existence of β‐D‐galactose (Wu et al ., 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Among these activities, the best established was reported to be antioxidation (Wu et al ., 2020). However, the antioxidant activity of seaweeds polysaccharides is related to their sulphate content, molecular weight, monosaccharide composition, linkage patterns and chain conformation (Qiu et al ., 2020). Sulphate content and molecular weight are the main factors affecting the antioxidant activity of polysaccharides (Zhang et al ., 2010).…”

Section: Introductionmentioning

confidence: 99%

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Effects of origin and harvest period on characterisation, structure and antioxidant activity of polysaccharides derived from Porphyra haitanensis

Pan

Haichao

et al. 2021

Int J of Food Sci Tech

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In the present study, the influences of different origins and harvest periods on the characterisation, structure and antioxidant activity of Porphyra haitanensis polysaccharides (PHPs) were investigated. PHPR03 obtained from the third harvest period (late December) in Raoping possessed the highest content of sulphate group (14.70%), the lowest viscosity (434.34 mLÁg −1 ) and exhibited better antioxidant activity. FTIR spectrum confirmed that PHPs obtained in different origins and harvest periods had similar functional groups (O-H, C-H and C-O group). Thermal gravimetric analysis suggested that PHPR03 has good thermal stability until 182 °C. PHPR03 microstructure was detected using scanning electron microscopy, and it was mainly irregular flocs. Atomic force microscope data showed that its diameter and height ranged from 1.32 to 1.99 μm and 14.16 to 34.92 nm, respectively. X-ray diffraction and Congo red experiments indicated that PHPR03 belongs to amorphous material with weak rigidity and exists in the form of random coils in an aqueous solution. PHPR03 resulted in a decrease of thiobarbituric acidreactive substances value of ground pork. This study provides the theoretical basis for rational utilisation and further applications in the food industry of PHPs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of origin and harvest period on characterisation, structure and antioxidant activity of polysaccharides derived from Porphyra haitanensis

Pan

Haichao

et al. 2021

Int J of Food Sci Tech

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“…It is composed of repeating units of galactose and 3,6-anhydrogalactose, with alternating units of galactose-6-sulphate and 6- O -methyl-galactose [ 126 ]. Average molecular weight ranges from 14 to 201 kDa [ 127 , 128 ]. Porphyran is soluble in hot water and has similar structural functions to carrageenan, though its higher viscosity limits its pharmaceutical applications [ 128 , 129 ].…”

Section: Discussionmentioning

confidence: 99%

“…Porphyran is soluble in hot water and has similar structural functions to carrageenan, though its higher viscosity limits its pharmaceutical applications [ 128 , 129 ]. Porphyran has shown potential antioxidant and anti-inflammatory effects in cell studies using RAW264.7 cell line [ 125 ] and was found to promote cell migration and proliferation in intestinal epithelial cells [ 127 ]. It also has antitumor activity against HeLa cells [ 130 ], HT-29 colon cancer cells and AGS gastric cancer cells [ 131 ].…”

Section: Discussionmentioning

confidence: 99%

Seaweed Components as Potential Modulators of the Gut Microbiota

2021

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Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. However, it is also necessary to confirm these potential, therapeutic effects in large-scale clinical trials. Where possible, we have cited information concerning these trials.

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Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut‐Liver Axis in Diet‐Induced High‐Fat Mesocricetus auratus through Multiple Integrated Omics

Zeng

Chen

Wang

et al. 2023

Molecular Nutrition Food Res

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Scope Hyperlipidemia is currently a global public health problem severely affecting people's physical and mental health, as well as their quality of life. Methods and results The present study is aimed at revealing the mechanism of Porphyra haitanensis polysaccharide (PHP) in decreasing blood lipids by acting through gut‐liver axis in Mesocricetus auratus fed a high‐fat diet. PHP significantly prevented increases in serum total cholesterol, triglycerides and low‐density lipoprotein cholesterol, and alleviated damage to liver cells induced by a high‐fat diet M. auratus, in a dose‐dependent manner. PHP promotes proliferation of Muribaculaceae and Faecalibaculum, thereby enhancing the production of butyric acid both in the colon and liver, particularly high‐dose PHP (HPHP). Low‐dose PHP (LPHP) promotes the expression of phosphatidylcholine metabolites and fatty acid transport genes, and inhibits the expression of genes involved in fat degradation (Abhd5), adipogenesis (Me1), fatty acid synthesis (Fasn and Pnpla3), and fatty acid chain elongation (Elovl6) in the liver. However, HPHP inhibits the expression of triglyceride metabolites and promotes the expression of fatty acid transporter (CD36), fatty acid oxidation (Acacb), and peroxisome proliferator‐activated receptor gamma (PPARg) genes in the liver. Conclusion PHP regulates lipid metabolism through the gut microbiota, and the gut‐liver axis plays an important role in its hypolipidemic effects.

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Physicochemical properties and potential beneficial effects of porphyran from Porphyra haitanensis on intestinal epithelial cells

Cited by 42 publications

References 37 publications

Effects of origin and harvest period on characterisation, structure and antioxidant activity of polysaccharides derived from Porphyra haitanensis

Effects of origin and harvest period on characterisation, structure and antioxidant activity of polysaccharides derived from Porphyra haitanensis

Seaweed Components as Potential Modulators of the Gut Microbiota

Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut‐Liver Axis in Diet‐Induced High‐Fat Mesocricetus auratus through Multiple Integrated Omics

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