Physicochemical properties of marine collagen-alginate biomaterial

Soon, K. S.; Hii, S. L.; Wong, Ching-Lee; Leong, Loong Kong; Woo, Kwan-Kit

doi:10.1063/1.5010533

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Considerable use of these products in different industries and environments demonstrates their importance [8]. Among the various biologics combined with ALG in biomaterial science, COL has been extensively used for wound healing and tissue regeneration [9,10]. However, very few marine-based COL are combined with ALG of similar origin.…”

Section: Introductionmentioning

confidence: 99%

Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Naidu

Karunya

Kanchana

et al. 2019

Heliyon

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Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era.

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Section: Introductionmentioning

confidence: 99%

Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Naidu

Karunya

Kanchana

et al. 2019

Heliyon

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“…Our previous study [ 28 ] revealed that fish skin contains promising amounts of collagen yield from using an acid extraction method. To further expand the application of fish skin collagen, a hybrid hydrogel of collagen and alginate was developed [ 29 ]. The results from the study showed improved mechanical properties of collagen-alginate films [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Our earlier study on fish skin collagen revealed collagen-alginate hybrid hydrogels improved the mechanical properties and denaturation temperature ( T d ) [ 29 ]. Therefore, the present research attempts to understand the rheological behavior for fish skin collagen, brown seaweed alginate, and collagen-alginate hybrid hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Utilizing Fish Skin of Ikan Belida (Notopterus lopis) as a Source of Collagen: Production and Rheology Properties

et al. 2022

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Collagen hydrogels have been extensively applied in biomedical applications. However, their mechanical properties are insufficient for such applications. Our previous study showed improved mechanical properties when collagen was blended with alginate. The current study aims to analyze the physico-chemical properties of collagen-alginate (CA) films such as swelling, porosity, denaturation temperature (Td), and rheology properties. Collagen was prepared from discarded fish skin of Ikan Belida (Notopterus lopis) that was derived from fish ball manufacturing industries and cross-linked with alginate from brown seaweed (Sargasum polycystum) of a local species as a means to benefit the downstream production of marine industries. CA hydrogels were fabricated with ratios (v/v) of 1:1, 1:4, 3:7, 4:1, and 7:3 respectively. FTIR spectrums of CA film showed an Amide I shift of 1636.12 cm−1 to 1634.64 cm−1, indicating collagen-alginate interactions. SEM images of CA films show a porous structure that varied from pure collagen. DSC analysis shows Td was improved from 61.26 °C (collagen) to 83.11 °C (CA 3:7). CA 4:1 swelled nearly 800% after 48 h, correlated with the of hydrogels porosity. Most CA demonstrated visco-elastic solid characteristics with greater storage modulus (G′) than lost modulus (G″). Shear thinning and non-Newtonian behavior was observed in CA with 0.4% to 1.0% (w/v) CaCl2. CA hydrogels that were derived from discarded materials shows promising potential to serve as a wound dressing or ink for bio printing in the future.

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Physicochemical properties of marine collagen-alginate biomaterial

Cited by 2 publications

References 11 publications

Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Utilizing Fish Skin of Ikan Belida (Notopterus lopis) as a Source of Collagen: Production and Rheology Properties

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