Physicochemical Properties of Purified Staphylococcal Enterotoxin B

Wagman, Jack; Edwards, Richard C.; Schantz, Edward J.

doi:10.21236/ad0444380

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1967

1970

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“…Temperature variation Staphylococcus spp. Fractionation of this exwas approximately ± 2' C. The conditions are tract resulted in a B-type enterotoxin, generalsummarized in table I. ly referred to as SEB (2). The LPS endotoxin was a commercial preparation of lipopolysac-…”

Section: Environmental Conditionsmentioning

confidence: 99%

Influence of Temperature on the Effects of Enterotoxin and Endotoxin in Mice

Glenn¹

1970

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Section: Environmental Conditionsmentioning

confidence: 99%

Influence of Temperature on the Effects of Enterotoxin and Endotoxin in Mice

Glenn¹

1970

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Influence of Thorotrast Blockade and Acute Renal Artery Ligation on Disapperance of Staphylococcal Enterotoxin B from Blood

1967

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The protein toxin staphylococcal enterotoxin B (SEB) produces a clinical syndrome somewhat similar to that of gram-negative endotoxins. Our studies indicate a further similarity to endotoxin in that SEB is rapidly cleared from the plasma of monkeys. However, data reported herein show that an effective Thorotrast blockade of the reticuloendothelial system (RES) does not produce a significant change in the rapid disappearance kinetics of SEB. This observation contrasts with what is known regarding endotoxin clearance. Furthermore, other data reported herein indicate that acute bilateral renal artery ligation produces a profound delay in SEB clearance from plasma. A possible mechanism for renal degradation of SEB is theorized. The RES may play a less important role in the clearance of SEB. This finding contrasts with the demonstrated importance of the RES in clearance and detoxification of gram-negative endotoxin.

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Physicochemical Properties of Purified Staphylococcal Enterotoxin B

Cited by 2 publications

References 2 publications

Influence of Temperature on the Effects of Enterotoxin and Endotoxin in Mice

Influence of Temperature on the Effects of Enterotoxin and Endotoxin in Mice

Influence of Thorotrast Blockade and Acute Renal Artery Ligation on Disapperance of Staphylococcal Enterotoxin B from Blood

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