Physicochemical studies of acetaminophen in Water-Peg 400 systems

Yurquina, Alicia; Manzur, María E.; Brito, P.; Manzo, Rubén H.; Molina, M.A.A.

doi:10.1016/j.molliq.2006.05.005

Cited by 23 publications

(12 citation statements)

References 18 publications

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“…2 our solubility values expressed in molarity are in good agreement with those reported by Prakongpan and Nagai [8] at 303.15 K; whereas, Fig. 3 shows that our values expressed in mole fraction are concordant with the ones reported by Yurquina et al [9] at 298.15 K. The little discrepancies observed in neat PEG 400 (1), where our values are greater than the ones reported in the literature, could be attributed to different dehydration times of this hygroscopic cosolvent or different drug saturation equilibration times. None other solubility value has been reported in the literature for this drug in these mixtures and therefore no more comparisons can be made.…”

Section: Resultssupporting

confidence: 92%

Solution thermodynamics of acetaminophen in some PEG 400+water mixtures

Ahumada

Delgado

Martínez

2012

Fluid Phase Equilibria

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Section: Resultssupporting

confidence: 92%

Solution thermodynamics of acetaminophen in some PEG 400+water mixtures

Ahumada

Delgado

Martínez

2012

Fluid Phase Equilibria

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“…For majority of the drugs in the dataset, solubility is higher in PEG than in water. PEG has lower values of surface tension, dielectric constant and solubility parameter than water (Yurquina et al, 2007) and when added to water such properties for the mixtures will be lower than those of the pure water. In order to describe the behavior of solvents and solvent mixtures, cohesive and adhesive forces between molecules have been considered.…”

Section: Prediction Accuracy Of the Modelsmentioning

confidence: 98%

Estimation of drug solubility in water, PEG 400 and their binary mixtures using the molecular structures of solutes

Ghafourian

Bozorgi

2010

European Journal of Pharmaceutical Sciences

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With the aim of solubility estimation in water, polyethylene glycol 400 (PEG) and their binary mixtures, Quantitative Structure -Property Relationships (QSPRs) were investigated to relate the solubility of a large number of compounds to the descriptors of the molecular structures. The relationships were quantified using linear regression analysis (with descriptors selected by stepwise regression) and Formal Inference -based Recursive Modeling (FIRM). The models were compared in terms of the solubility prediction accuracy for the validation set. The resulting regression and FIRM models employed a diverse set of molecular descriptors explaining crystal lattice energy, molecular size, and solute -solvent interactions. Significance of molecular shape in compound's solubility was evident from several shape descriptors being selected by FIRM and stepwise regression analysis. Some of these influential structural features, e.g. connectivity indexes and Balaban topological index, were found to be related to the crystal lattice energy. The results showed that regression models outperformed most FIRM models and produced higher prediction accuracy. However, the most accurate estimation was achieved by the use of a combination of FIRM and regression models. The results also showed that the use of melting point in regression models improves the estimation accuracy especially for solubility in higher concentrations of PEG. Aqueous or PEG/water solubilities can be estimated by these models with root mean square error of below 0.70.

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“…14, the projectile velocity is plotted as a ratio of initial to final velocities and the independent variable is taken to be the dimensionless impact parameter (C x l u p0 t)/( p d p ), as proposed by Stepka et al [1]. Experimental points were computed from optically measured velocities for u p0 and C x , liquid densities and viscosities were taken from [14] and [15]. Eq.…”

Section: Projectile Velocity Lossmentioning

confidence: 99%

Experimental study of hydraulic ram effects on a liquid storage tank: Analysis of overpressure and cavitation induced by a high-speed projectile

Lecysyn

Bony-Dandrieux

Aprin

et al. 2010

Journal of Hazardous Materials

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This work is part of a project for evaluating catastrophic tank failures caused by impacts with a high-speed solid body. Previous studies on shock overpressure and drag events have provided analytical predictions, but they are not sufficient to explain ejection of liquid from the tank. This study focuses on the hydrodynamic behavior of the liquid after collision to explain subsequent ejection of liquid. The study is characterized by use of high-velocity projectiles and analysis of projectile dynamics in terms of energy loss to tank contents. New tests were performed at two projectile velocities (963 and 1255 m s(-1)) and over a range of viscosities (from 1 to 23.66 mPa s) of the target liquid. Based on data obtained from a high-speed video recorder, a phenomenological description is proposed for the evolution of intense pressure waves and cavitation in the target liquids.

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Physicochemical studies of acetaminophen in Water-Peg 400 systems

Cited by 23 publications

References 18 publications

Solution thermodynamics of acetaminophen in some PEG 400+water mixtures

Solution thermodynamics of acetaminophen in some PEG 400+water mixtures

Estimation of drug solubility in water, PEG 400 and their binary mixtures using the molecular structures of solutes

Experimental study of hydraulic ram effects on a liquid storage tank: Analysis of overpressure and cavitation induced by a high-speed projectile

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